DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-alpha and Lrit1

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_666357.2	Gene:	Lrit1 / 239037	MGIID:	2385320	Length:	624	Species:	Mus musculus

Alignment Length:	346	Identity:	79/346 - (22%)
Similarity:	120/346 - (34%)	Gaps:	98/346 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPVSAKRLLRNFQFTSCDRNGKMLI--HLLLIVSLLEAIGAFQPEFVESISNVSVAVG-RDATFT 62
            :|..|...|.|..|.....|..|.:  .||.:.:.|:. |.|.     |..:..:.:| :|..:.
Mouse   146 LPPEAAHFLENLTFLDLSNNQLMRLPEELLDVWAHLKT-GPFL-----SGHHARLILGLQDNPWV 204

  Fly    63 CHVR-----HLGGYRVGWLKADTKAIQAIHENVITHNPR----VTVSHLDQNTWNLHIKAVSEED 118
            |..|     ||   ..||:.::...|:|   .:...:||    |..|.|:..      |..|.|.
Mouse   205 CDCRLYDLVHL---LDGWVSSNLIFIEA---RLRCASPRSLAGVAFSQLELR------KCQSPEL 257

  Fly   119 RGGYMCQLNTDPMKSQIGFLDVVIPPDFISEDTSSDVIVPEGSSVRLTCRARGYPEPIVTWRRED 183
            |.|.                              :.:|.|.||:|.|.|.|.|.|.|.::|||.:
Mouse   258 RPGV------------------------------TSIISPLGSTVLLRCGATGIPGPEMSWRRAN 292

  Fly   184 GNEIVLKDNVGTKTLAPSFRGEVLKLSKISRNEMGSYLCIASNGVPPSVSKRISLSIHFHPVIQV 248
            |..  |...|..:..:......:|.|..:|..:.|.|:|.|.|.:..| ...|||.:
Mouse   293 GRP--LNGTVHQEVSSDGSSWTLLDLPVVSLFDSGDYICQAKNFLGAS-ETLISLIV-------- 346

  Fly   249 PNQLVGAPLGTDVQIECHVEASPKSINYWIKDTGE---------MIVTSGKYHVQE-----SSQS 299
                      |:.|........|..:  |.: |||         .:|.....|:.|     :..|
Mouse   347 ----------TEPQTSTGYSGIPGVL--WAR-TGEGAEAAAYNNKLVARHVPHMPEHVALATKPS 398

  Fly   300 MYETKMSMIVRKFQKDDVGSY 320
            |...|..:.::.||.|..|.:
Mouse   399 MPSIKEELALQNFQMDVPGEF 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	20/89 (22%)
		Ig	51..131	CDD:299845	20/89 (22%)
		I-set	144..240	CDD:254352	29/95 (31%)
		IGc2	159..228	CDD:197706	23/68 (34%)
		Ig	244..337	CDD:299845	17/91 (19%)
		I-set	244..337	CDD:254352	17/91 (19%)
Lrit1	NP_666357.2	LRRNT	23..61	CDD:214470
		LRR 1	60..81
		LRR_8	63..143	CDD:290566
		leucine-rich repeat	64..84	CDD:275378
		LRR 2	84..105
		leucine-rich repeat	85..132	CDD:275378
		LRR 3	108..129
		LRR_8	131..>176	CDD:290566	8/29 (28%)
		LRR_4	131..172	CDD:289563	7/25 (28%)
		LRR 4	132..153		2/6 (33%)
		leucine-rich repeat	133..156	CDD:275378	3/9 (33%)
		LRR 5	156..177		6/20 (30%)
		leucine-rich repeat	157..180	CDD:275378	5/22 (23%)
		leucine-rich repeat	181..205	CDD:275378	6/29 (21%)
		TPKR_C2	201..>241	CDD:301599	10/45 (22%)
		Ig	258..346	CDD:299845	31/120 (26%)
		IG_like	268..346	CDD:214653	27/80 (34%)
		FN3	432..502	CDD:214495
		LRR 6	526..549
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900