DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-alpha and IGSF9B

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens

Alignment Length:	357	Identity:	94/357 - (26%)
Similarity:	140/357 - (39%)	Gaps:	87/357 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LEAIGAF----QPEFVESISNVSVAVGRDATFTCHVRH-LGG----YRVGWLKADTKAIQAIHEN 89
            |.|.||.    :|||      |:...|......|.|.| :.|    |.|.|.|.....  .|...
Human    18 LAAEGAHGLREEPEF------VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPI--PIFIK 74

  Fly    90 VITHNPRVTVSHLDQNTWNLHIKA------VSEEDRGGYMC-------QLNTDPMKSQIGFLDVV 141
            ...:.|.|...:..:.  :||.||      |..||:|.|.|       |.:|....|.: .|.:.
Human    75 FGYYPPHVDPEYAGRA--SLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWV-HLTIN 136

  Fly   142 IPPDFISEDTSSDVIVPEGSSVRLTCRARGYPEPIVTWRREDGNEIVLKDNVGTKTLAPSFRGEV 206
            .||.| :|.....:...||.|:.:||.|.|.|:|||||.:|           || .|..|.:.:|
Human   137 APPTF-TETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKE-----------GT-LLGASGKYQV 188

  Fly   207 ----LKLSKISRNEMGSYLCIASNGVPPSVSKRISLSIH-FHPVIQVPNQLVGAP------LGTD 260
                |.::.:||.:.|:|.|.|.     |:...   ::| .|.::|.|..:|..|      :..|
Human   189 SDGSLTVTSVSREDRGAYTCRAY-----SIQGE---AVHTTHLLVQGPPFIVSPPENITVNISQD 245

  Fly   261 VQIECHVEASPKSINY-WIKDTGEMIVTSGKYHVQESSQSMYETKM--------SMIVRKFQKDD 316
            ..:.|..||.|.::.| |             |...|:.....:.|:        ::|:.:.:.:|
Human   246 ALLTCRAEAYPGNLTYTW-------------YWQDENVYFQNDLKLRVRILIDGTLIIFRVKPED 297

  Fly   317 VGSYRCIAKNSLGEVDSSIRLYEIPGPNRNKN 348
            .|.|.|:..||||...|:.....:..|.|..|
Human   298 SGKYTCVPSNSLGRSPSASAYLTVQYPARVLN 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	24/97 (25%)
		Ig	51..131	CDD:299845	25/97 (26%)
		I-set	144..240	CDD:254352	30/99 (30%)
		IGc2	159..228	CDD:197706	26/72 (36%)
		Ig	244..337	CDD:299845	24/107 (22%)
		I-set	244..337	CDD:254352	24/107 (22%)
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653	26/94 (28%)
		Ig	41..115	CDD:143165	21/77 (27%)
		I-set	139..225	CDD:254352	32/106 (30%)
		IGc2	153..210	CDD:197706	25/68 (37%)
		I-set	229..321	CDD:254352	22/104 (21%)
		Ig	235..321	CDD:299845	21/98 (21%)
		IG_like	331..414	CDD:214653
		Ig	<353..414	CDD:299845
		IG_like	426..505	CDD:214653
		Ig	442..505	CDD:299845
		FN3	510..601	CDD:238020
		FN3	617..699	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910