DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-alpha and Cntn3

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_032805.2	Gene:	Cntn3 / 18488	MGIID:	99534	Length:	1028	Species:	Mus musculus

Alignment Length:	327	Identity:	84/327 - (25%)
Similarity:	137/327 - (41%)	Gaps:	66/327 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SNVSVAVGRDATFTC-HVRHLGGYRVGWLKADTKAIQAIHENVITHNPRVTVSHLDQNTWNLHIK 112
            |.|||..|:.....| ...|.|.....|:..:       :.:.:..:.|..||   |.|.:|:|.
Mouse   130 STVSVREGQGVVLLCGPPPHSGELSYAWVFNE-------YPSFVEEDSRRFVS---QETGHLYIA 184

  Fly   113 AVSEEDRGGYMCQLNTDPMKSQI--GFLDVVIPPDFI--SEDTSSDVIVPE------GSSVRLTC 167
            .|...|.|.|.|.:.:....:::  ....:|:..|.:  ..:...:|..||      ||:|||.|
Mouse   185 KVEPSDVGNYTCVVTSTVTNTRVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVRLEC 249

  Fly   168 RARGYPEPIVTWRREDG----NEIVLKDNVGTKTLAPSFRGEVLKLSKISRNEMGSYLCIASNGV 228
            .|.|.|.|.:.|||.||    |:|.|:          .|.| :|::....:.:.|||.|||.|..
Mouse   250 FALGNPVPQINWRRSDGMPFPNKIKLR----------KFNG-MLEIQNFQQEDTGSYECIAENSR 303

  Fly   229 PPSVSKRISLSIHFHPV-IQVPNQLVGAPLGTDVQI--------ECHVEASPKSINYWIKDTGEM 284
            ..:|: |..|:.:..|. :|         |..||:|        ||.....||....|:|: |:.
Mouse   304 GKNVA-RGRLTYYAKPYWLQ---------LLRDVEIAVEDSLYWECRASGKPKPSYRWLKN-GDA 357

  Fly   285 IVTSGKYHVQESSQSMYETKMSMIVRKFQKDDVGSYRCIAKNSLGEVDSSIRLYEI-PGPNRNKN 348
            :|...:..::..         ::.:......|.|.::|||:|..|.:.||..|..: ..|:.::|
Mouse   358 LVLEERIQIENG---------ALTITNLNVTDSGMFQCIAENKHGLIYSSAELKVVASAPDFSRN 413

  Fly   349 PL 350
            |:
Mouse   414 PM 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	21/80 (26%)
		Ig	51..131	CDD:299845	20/80 (25%)
		I-set	144..240	CDD:254352	35/107 (33%)
		IGc2	159..228	CDD:197706	29/78 (37%)
		Ig	244..337	CDD:299845	23/101 (23%)
		I-set	244..337	CDD:254352	23/101 (23%)
Cntn3	NP_032805.2	Ig	25..120	CDD:416386
		Ig strand A	27..31	CDD:409353
		Ig strand A'	34..39	CDD:409353
		Ig strand B	45..53	CDD:409353
		Ig strand C	58..64	CDD:409353
		Ig strand C'	66..69	CDD:409353
		Ig strand D	76..80	CDD:409353
		Ig strand E	82..88	CDD:409353
		Ig strand F	95..104	CDD:409353
		Ig strand G	107..120	CDD:409353
		Ig	129..214	CDD:416386	21/93 (23%)
		Ig strand A	130..135	CDD:409353	3/4 (75%)
		Ig strand B	139..145	CDD:409353	0/5 (0%)
		Ig strand C	153..159	CDD:409353	1/5 (20%)
		Ig strand C'	164..166	CDD:409353	0/1 (0%)
		Ig strand D	171..176	CDD:409353	3/7 (43%)
		Ig strand E	179..183	CDD:409353	1/3 (33%)
		Ig strand F	193..201	CDD:409353	2/7 (29%)
		Ig strand G	203..214	CDD:409353	0/10 (0%)
		Ig	227..315	CDD:416386	34/99 (34%)
		Ig strand A	227..232	CDD:409353	0/4 (0%)
		Ig strand A'	235..240	CDD:409353	1/4 (25%)
		Ig strand B	243..252	CDD:409353	5/8 (63%)
		Ig strand C	258..262	CDD:409353	0/3 (0%)
		Ig strand C'	265..267	CDD:409353	1/1 (100%)
		Ig strand D	276..279	CDD:409353	0/12 (0%)
		Ig strand E	280..285	CDD:409353	2/5 (40%)
		Ig strand F	293..301	CDD:409353	6/7 (86%)
		Ig strand G	304..315	CDD:409353	3/11 (27%)
		Ig	320..403	CDD:416386	23/101 (23%)
		Ig strand A'	326..330	CDD:409353	2/3 (67%)
		Ig strand B	334..342	CDD:409353	2/7 (29%)
		Ig strand C	348..353	CDD:409353	1/4 (25%)
		Ig strand C'	355..358	CDD:409353	1/2 (50%)
		Ig strand D	363..367	CDD:409353	0/3 (0%)
		Ig strand E	369..374	CDD:409353	0/13 (0%)
		Ig strand F	383..390	CDD:409353	3/6 (50%)
		Ig strand G	394..403	CDD:409353	3/8 (38%)
		Ig	408..496	CDD:416386	3/8 (38%)
		Ig strand A	408..413	CDD:409353	1/4 (25%)
		Ig strand A'	416..421	CDD:409353	84/327 (26%)
		Ig strand B	425..432	CDD:409353
		Ig strand C	440..444	CDD:409353
		Ig strand D	458..461	CDD:409353
		Ig strand E	462..467	CDD:409353
		Ig strand F	475..483	CDD:409353
		Ig strand G	489..496	CDD:409353
		Ig	498..598	CDD:416386
		Ig strand A	498..504	CDD:409353
		Ig strand A'	507..512	CDD:409353
		Ig strand B	515..523	CDD:409353
		Ig strand C	532..536	CDD:409353
		Ig strand E	560..564	CDD:409353
		Ig strand F	573..580	CDD:409353
		Ig strand G	587..591	CDD:409353
		FN3	598..695	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	684..714
		FN3	703..795	CDD:238020
		FN3	805..898	CDD:238020
		FN3	906..991	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910