DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-alpha and rig-3

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_509155.1	Gene:	rig-3 / 180958	WormBaseID:	WBGene00004370	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	358	Identity:	65/358 - (18%)
Similarity:	109/358 - (30%)	Gaps:	140/358 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 LHIKAVSEEDRGGYMCQLNTDPMKSQIGFLDVVIPPDFISEDTSSDVIVPEGSSVRLTCRARGYP 173
            |.:.|||..|          .|..::..  .:||..:.:..||:: :.|.||..:.::|.... .
Worm    16 LFVSAVSASD----------SPSSNEAN--PIVISSEAMDYDTNT-ITVREGKKLMVSCVFES-D 66

  Fly   174 EPI----VTWRREDGNEI----------VLKDNVGTKTLAPSFRGEVLKLSKISRNEMGSYLCIA 224
            |.|    :.|::.:||.|          |:.:..|:|     .|...|..|.:...:.|.|.|..
Worm    67 EQIHKSDLLWKQANGNNIDGESNPSLFSVILNEKGSK-----HRKTSLHFSSVHTRDTGLYTCTG 126

  Fly   225 SNGVPPSVSKRISLSIHFHPVIQVPNQ--LVGAPLGTDVQIECHVE---------------ASPK 272
            ......:..|.|.|.:  .|.|:..::  :.||.||..:.|:|.|:               ..|.
Worm   127 RTAGGENFEKTIKLVV--LPAIEWNDKDTVKGALLGEPITIDCGVKGPSGKEPMIQMTNGNGEPL 189

  Fly   273 SINYWI-----------------------------------------KDTGEMIVTSGKYHVQES 296
            ....|.                                         ||....:.|..::..:||
Worm   190 DEEIWTIAGNEATIDSLKKEHAELTVSCITIEMHQETSKEEFPVVDRKDVNIEVYTLPEFETEES 254

  Fly   297 SQ---------------------------SMY----ETKMS----------------MIVRKFQK 314
            .|                           :.|    |.|||                :.:....:
Worm   255 VQYTVIDNHVRDAIIYCNVTHSFPPVRHYTFYHGDEEIKMSDKFNIFVNVGVSQGAHLKIHNVNE 319

  Fly   315 DDVGSYRCIAKNSLGEVDSSIRLYEIPGPNRNK 347
            :|:|:|:|.|.|...:...:|.|.|...|...|
Worm   320 NDLGTYKCEANNIKAKSYHTIHLREANAPAEPK 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	5/19 (26%)
		Ig	51..131	CDD:299845	5/21 (24%)
		I-set	144..240	CDD:254352	24/109 (22%)
		IGc2	159..228	CDD:197706	18/82 (22%)
		Ig	244..337	CDD:299845	29/197 (15%)
		I-set	244..337	CDD:254352	29/197 (15%)
rig-3	NP_509155.1	IG_like	48..142	CDD:214653	22/100 (22%)
rig-3	NP_509155.1	Ig	267..341	CDD:319273	11/73 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900