DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-alpha and igcm-2

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001362087.1	Gene:	igcm-2 / 180913	WormBaseID:	WBGene00020130	Length:	802	Species:	Caenorhabditis elegans

Alignment Length:	276	Identity:	75/276 - (27%)
Similarity:	116/276 - (42%)	Gaps:	49/276 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 IKAVSEEDRGGYMCQLN------TDPMKSQIGFLDVVIPPDFISEDTSSDVIVPEGSSVRLTCRA 169
            |.:|::.|.|.|.|.:.      |.|.|.....|.|.:||..||...::.:....|:.:...|:|
Worm    85 IHSVTDGDAGVYQCIVTKFSKQPTRPEKGLSAKLVVNVPPVIISPSKNAIIHKKVGADLIFECKA 149

  Fly   170 RGYPEPIVTWRREDGNEIVLKDNVGTKTLAPSFRGEVLKLSKISRNEMGSYLCIASNGVPPSVSK 234
            .|.|.|.:||.|   ||.::..:            .||.||.:...:.|.|.|:|.|....|.|
Worm   150 EGAPSPEITWSR---NEQIISTS------------PVLTLSNLEEGDKGLYTCLAVNIEGNSTS- 198

  Fly   235 RISLSIHFHPVIQVPNQLVGAPL------GTDVQIECHVEASPKSINY-WIKDTGEMIVTS-G-K 290
              |:.:.|.....:  .|:  ||      |::|...||..|...:|:| |:.:...:..|| | :
Worm   199 --SIDVRFTKATIL--DLI--PLNKTVIEGSNVFWHCHANAQATAISYSWLFEKKPIKTTSLGLR 257

  Fly   291 YHVQESSQSMYETKMSMIVRKFQKDDVGSYRCIAKNSLGEVDSS---IRLYEIPGPNRNKNPLNG 352
            .:::....|:.:.:         |.|.|.|.|.||||.||..||   :.::..|.|..:..|:..
Worm   258 SNIRSGDLSLQDVR---------KSDSGWYTCEAKNSAGETTSSTAYLHVFYPPEPLSSHQPVQT 313

  Fly   353 GGKGGGAGGSLDADAN 368
            ...|.....|.|..||
Worm   314 VASGRNTTVSCDVIAN 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	6/23 (26%)
		Ig	51..131	CDD:299845	7/25 (28%)
		I-set	144..240	CDD:254352	26/95 (27%)
		IGc2	159..228	CDD:197706	20/68 (29%)
		Ig	244..337	CDD:299845	28/104 (27%)
		I-set	244..337	CDD:254352	28/104 (27%)
igcm-2	NP_001362087.1	IG_like	23..101	CDD:214653	6/15 (40%)
		Ig	124..200	CDD:386229	25/93 (27%)
		IG_like	214..298	CDD:214653	27/92 (29%)
		Ig_3	309..371	CDD:372822	6/21 (29%)
		Ig	389..467	CDD:386229
		FN3	476..548	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810