DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-alpha and Papln

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001192272.1	Gene:	Papln / 170721	MGIID:	2386139	Length:	1302	Species:	Mus musculus

Alignment Length:	357	Identity:	77/357 - (21%)
Similarity:	120/357 - (33%)	Gaps:	106/357 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SNVSVAVGRDATFTCHVRHLGGYRVGWLKADTKAIQAIHENVITHNPRVTVSHLDQNTWNLHIKA 113
            |.|..|.|:.....|.......::.||.|..              .|..:..:..|...:|.|..
Mouse   934 SLVQAAPGQAVQLFCPGNIPSEFQAGWQKEG--------------RPISSNRYQLQADGSLIISR 984

  Fly   114 VSEEDRGGYMC---QLNTDPMKSQI---GFLDVVIP---PDFISEDTSSD--------------- 154
            :..||.|.|.|   :...:|.:.|:   |....|.|   |....|..:.|
Mouse   985 LRPEDAGIYSCGSHRPGHEPQEIQLRVTGGDMAVFPEGQPRHFPEPRNPDLGHGPPHRGTGAEAG 1049

  Fly   155 ---VIVPE----------------------GSSVRLTCRARGYPEPIVTWRREDGNEIVLKDNVG 194
               |:.|.                      |..:||||||.|:|.|.:.|:| ||.
Mouse  1050 GHRVLSPSHPRPATRLRLDRTQPGVVDASPGQRIRLTCRAEGFPVPTIEWQR-DGQ--------- 1104

  Fly   195 TKTLAPSFRGEV-----LKLSKISRNEMGSYLCIASNG-------VPPSVSKRISLSIHFHPVIQ 247
               |..|.|.:|     |.:|::...:.|.|.|:|.||       |...|.:.:::: ...|.:.
Mouse  1105 ---LVSSPRHQVQPDGSLVISRVDVEDGGYYSCVAFNGQDRDQRWVQLRVLRELTIT-GLPPAVT 1165

  Fly   248 VPNQLVGAPLGTDVQIECHVEASPKSINYWIKDTGEMIVTSGKYHVQESSQSMYETKMSMIVRKF 312
            |..       |...::.|.|  :.:|:|......|..|...| :.|.:|...      ::::...
Mouse  1166 VAE-------GDTARLLCVV--AGESVNIRWSRNGLPIQADG-HRVHQSPDG------TLLIHNL 1214

  Fly   313 QKDDVGSYRCIAKNSLGEVDSSIRL-YEIPGP 343
            :..|.|||.|.|......|..|..: ..:|.|
Mouse  1215 RPRDEGSYTCSAFRGSQAVSRSTEVKVALPAP 1246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	17/82 (21%)
		Ig	51..131	CDD:299845	16/82 (20%)
		I-set	144..240	CDD:254352	33/147 (22%)
		IGc2	159..228	CDD:197706	26/102 (25%)
		Ig	244..337	CDD:299845	20/92 (22%)
		I-set	244..337	CDD:254352	20/92 (22%)
Papln	NP_001192272.1	TSP1	30..81	CDD:214559
		ADAM_spacer1	184..299	CDD:368694
		TSP1	309..362	CDD:214559
		TSP1	389..447	CDD:214559
		TSP1	447..504	CDD:214559
		TSP1	511..562	CDD:214559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..737
		Kunitz_BPTI	771..822	CDD:333766
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..924
		Papilin_u7	831..922	CDD:374683
		Ig	932..>995	CDD:386229	16/74 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1024..1064		5/39 (13%)
		I-set	1070..1141	CDD:369462	26/83 (31%)
		Ig	1157..1241	CDD:386229	20/100 (20%)
		PLAC	1257..1289	CDD:370061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900