DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gas8 and gas8

DIOPT Version :9

Sequence 1:	NP_001284841.1	Gene:	Gas8 / 31321	FlyBaseID:	FBgn0029667	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_955928.1	Gene:	gas8 / 323260	ZFINID:	ZDB-GENE-030131-1980	Length:	475	Species:	Danio rerio

Alignment Length:	481	Identity:	182/481 - (37%)
Similarity:	298/481 - (61%)	Gaps:	10/481 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPKGKKGKKGKKLPVLIDGVDTSAMTRDQLEAFALRLKAEMDREREERNYFQLERDKIRTFWEI 65
            ||||.|...|| |.|.::||:.|..|:::|||...:||:.|:|||||||||||||||||.|||||
Zfish     1 MPPKRKSSPKG-KTPTVVDGLSTEEMSKEQLEEHIMRLREELDREREERNYFQLERDKIHTFWEI 64

  Fly    66 TRQQLDETRYELQQKDKEIEATQDLADIDTKHVMQQMKHLQFENHNRLGEVRAEAMTQLKLAQEH 130
            ||:.|:|.:.||:.:::|:|..::...::.|...|::|||.:|..|.|.|::||::...||.|:.
Zfish    65 TRRHLEENKCELRNRERELEEVEERHQVEIKVYKQKVKHLLYEQQNMLSELKAESIISTKLLQDE 129

  Fly   131 HVLQENELQRDKRQLRRMLRERMEMSEMQLRQMEAHFNEKLLEQRITFERERKDNEMLHEEKMIE 195
            |...|.|..:|.|.|:..|:::...||..|:::....:|:..:.|..|.|:.::....:|::|.:
Zfish   130 HADLEKEQWKDMRSLKLELKQQELSSENVLKRIHLKHDEETTDLRNDFARQVQEIGSKYEKRMQK 194

  Fly   196 QKAKLDLFYGTQMFEVEERKNQQIKDLQDHHDLAFNDMKNYYNDITLNNLALIGSMKEQLEHLRK 260
            .:.:.:|...|::.|:|||||..|..|..:|:.|:.|::||::||...||.||.|:||:|:.::|
Zfish   195 LRQEEELRRKTEIHEIEERKNTHINMLMKNHEKAYRDIRNYFSDIVYKNLDLITSLKEELKEMKK 259

  Fly   261 QAERSDRIAADTAAENRRLKEPLEHANIQLNEYRRKLEFYERDKQQLSRLKTRNTRLEKKVKGLT 325
            ..|:.::..|:...:|:.|||..:.|..|:.|.:::|..||:||..|:|.:.|....::::|.|.
Zfish   260 NEEKRNKEMAEVLEQNKELKESSQKAKEQVAELQKQLANYEKDKSILTRSRARLKMSDREMKELK 324

  Fly   326 WEAETLILRNDSLVAEREGLKERFNDVIVELQQKTGLKNVLLERKIAALMREDEKRSIVLHETIA 390
            ||.|.|..|...:..||:.|..:|...|:|:|||:|.||:|||.|:..|....||:...|.|.::
Zfish   325 WELEVLEQRFSKVQLERDELYMKFTKAILEVQQKSGFKNLLLECKLNTLNDTLEKKEAQLSEVLS 389

  Fly   391 TCAPNF-AEKLTSLDERVGNIIDEKNKIILDLRYEVTKARKAHDDLLETYECKLKQYGVPTDELG 454
              |.|. ...|:.:..::..:::.||..|.||:|||.:..|||:|||:|.|.||:.:|:|.:||.
Zfish   390 --ASNLDPTTLSVVTHKLEEVLESKNHTIKDLQYEVARVCKAHNDLLKTSEAKLRAFGIPVEELC 452

  Fly   455 FKPIRNRDQQ--QLYVCGPAGIITEN 478
            |:|:::..|.  |    |||..::.:
Zfish   453 FEPLKSNGQSVGQ----GPAMFVSSS 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gas8	NP_001284841.1	GAS	221..421	CDD:290562	68/200 (34%)
gas8	NP_955928.1	Regulates microtubule-binding. /evidence=ECO:0000250\|UniProtKB:Q60779	1..113		56/112 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		11/21 (52%)
		Microtubule-binding. /evidence=ECO:0000250\|UniProtKB:Q60779	114..257		47/142 (33%)
		GAS	221..419	CDD:290562	68/199 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586678
Domainoid	1	1.000	174	1.000	Domainoid score	I3633
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1135
Inparanoid	1	1.050	337	1.000	Inparanoid score	I2354
OMA	1	1.010	-	-		QHG56364
OrthoDB	1	1.010	-	-		D1257437at2759
OrthoFinder	1	1.000	-	-		FOG0007350
OrthoInspector	1	1.000	-	-		oto39653
orthoMCL	1	0.900	-	-		OOG6_102980
Panther	1	1.100	-	-	LDO	PTHR31543
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4580
SonicParanoid	1	1.000	-	-		X5471
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940