Protein Alignment Gas8 and Gas8

DIOPT Version :10

• Sequence 1: NP_570065.2
• Gene: Gas8 / 31321
• FlyBaseID: FBgn0029667
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_061343.2
• Gene: Gas8 / 104346
• MGIID: 1202386
• Length: 478
• Species: Mus musculus
• Alignment Length: 477
• Identity: 217/477 - (45%)
• Similarity: 310/477 - (64%)
• Gaps: 5/477 - (1%)

  Fly     1 MPPKGKKGKKGK-KLPVLIDGVDTSAMTRDQLEAFALRLKAEMDREREERNYFQLERDKIRTFWE 64
            |.|| ||||||| |...::|||....||::|:|....|::.|:|||||||||||||||||.||||
Mouse     1 MAPK-KKGKKGKAKGTAIVDGVAPEDMTKEQVEEHVARIREELDREREERNYFQLERDKIHTFWE 64

  Fly    65 ITRQQLDETRYELQQKDKEIEATQDLADIDTKHVMQQMKHLQFENHNRLGEVRAEAMTQLKLAQE 129
            |||:||:|.:.||:.||:|:|..::...::.|...|::|||.:|:.|.|.||:||....:||||:
Mouse    65 ITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLAEVKAEGTVVMKLAQK 129

  Fly   130 HHVLQENELQRDKRQLRRMLRERMEMSEMQLRQMEAHFNEKLLEQRITFERERKDNEMLHEEKMI 194
            .|..||..|::|.|.|:..|:|:...:|:.::.:.....|::.:.|..|||:.::.|..:::||.
Mouse   130 EHRTQEGALRKDMRVLKVELKEQELANEVVIKNLCLKQAEEITKMRNDFERQVREIEAKYDKKMK 194

  Fly   195 EQKAKLDLFYGTQMFEVEERKNQQIKDLQDHHDLAFNDMKNYYNDITLNNLALIGSMKEQLEHLR 259
            ..:.:|||...|::.|||||||.||..|...|:.||.|:|||||||||||||||.|:|||:|.:|
Mouse   195 MLRDELDLRRKTEIHEVEERKNGQISTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMR 259

  Fly   260 KQAERSDRIAADTAAENRRLKEPLEHANIQLNEYRRKLEFYERDKQQLSRLKTRNTRLEKKVKGL 324
            |:.|..:|..|:...:||||.:||:.|..::||.:::|..:|||||.|...|.|....|:::|.|
Mouse   260 KKEEHMEREMAEVTLQNRRLADPLQKAKDEMNEMQKRLGNHERDKQILVCTKARLKVAERELKDL 324

  Fly   325 TWEAETLILRNDSLVAEREGLKERFNDVIVELQQKTGLKNVLLERKIAALMREDEKRSIVLHETI 389
            .||.|.|..|...:..|||.|..:|.|.|.|:|||||.||:|||||:.||....|||.:..:|.:
Mouse   325 KWEHEVLEQRFIKVQQEREELYRKFADAIQEVQQKTGFKNLLLERKLQALNAAVEKREVQFNEVL 389

  Fly   390 ATCAPNF-AEKLTSLDERVGNIIDEKNKIILDLRYEVTKARKAHDDLLETYECKLKQYGVPTDEL 453
            |  |.|. ...||.:..::.::::.||..|.||:||:.:..|||:|||.|||.||..:|:|.|.:
Mouse   390 A--ASNLDPTALTLVSRKLEDVLESKNTTIKDLQYELARVCKAHNDLLRTYEAKLLAFGIPLDNV 452

  Fly   454 GFKPIRNRDQQQLYVCGPAGII 475
            ||||:......|....||||::
Mouse   453 GFKPLETAVIGQTLGQGPAGLV 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gas8	NP_570065.2	Smc	<28..>438	CDD:440809	184/410 (45%)
		GAS	221..421	CDD:464001	90/200 (45%)
Gas8	NP_061343.2	Regulates microtubule-binding. /evidence=ECO:0000269|PubMed:17366626	1..114		60/113 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		16/28 (57%)
		PTZ00121	<67..355	CDD:173412	120/287 (42%)
		Microtubule-binding. /evidence=ECO:0000269|PubMed:17366626	115..258		64/142 (45%)
		GAS	221..420	CDD:464001	90/199 (45%)
		Interaction with SMO. /evidence=ECO:0000269|PubMed:21659505	357..478		53/120 (44%)