DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10803 and Ro60

DIOPT Version :9

Sequence 1:	NP_570064.1	Gene:	CG10803 / 31320	FlyBaseID:	FBgn0029666	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_001100653.1	Gene:	Ro60 / 304833	RGDID:	1305083	Length:	538	Species:	Rattus norvegicus

Alignment Length:	610	Identity:	130/610 - (21%)
Similarity:	237/610 - (38%)	Gaps:	119/610 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 MEKEAISNQPLKDEPSKDEPNQSEGTAISTIPAIDKLRRFCFIGSTDEPVYTTPALDLVVENNFA 128
            ||:.|...|||.|    ::...|||..:..:..:::|.||...||.....|.... .|.:||..|
  Rat     1 MEESANQLQPLSD----NQVANSEGGYVWQVTDMNRLHRFLCFGSEGGTCYIKEQ-KLGLENAEA 60

  Fly   129 SLKELCSQVSEDELVECLLSVLGSEPNEEQPPRPDEPLLILAVFFTTCEDEKKRNAVRNRFTDLI 193
            .:: |.......|:::.:.|.     ::|......||||......:.|.|...:.|......::.
  Rat    61 LIR-LIEDGRGSEVIQEIKSF-----SQEGRTAKQEPLLFALAICSQCADVSTKQAAFKAVPEVC 119

  Fly   194 TSESDLLLFVQLVKRVQKLLERKTPFNRTVRKAVLNWYGTK-SLDRLLHFWSIGDGNRWPAHRDL 257
            ...:.|..|:|..|.:::.: :...:.|.:||||.:||..| .:...|........|.| :|:||
  Rat   120 RIPTHLFTFIQFKKDLKESM-KCGMWGRALRKAVADWYNEKGGMAVALAVTKYKQRNGW-SHKDL 182

  Fly   258 LYRLHFRHANFLPE---IIAALRLLSSSPKEL-SQWPDFLTPLT----SFRETIEGVVKLRLLTD 314
            |...|.:     |.   :....:.::...||: .|:.:  .||:    ...:.:|.|.|::...|
  Rat   183 LRLSHLK-----PNSEGLAIVTKYITKGWKEVHEQYKE--KPLSVETDKLLKYLEAVEKVKRTKD 240

  Fly   315 PEQAISIVKKLSLSWEHVPFHLLHDPRLAHFLIPHMSYEQLLQKWPRLSRL--------NSRVRP 371
            ..:...:::      ||   .|:.:..|...|.....::.|||:.|..:.|        ||.:.|
  Rat   241 DLEVTHLIE------EH---QLVREQLLTSHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEP 296

  Fly   372 -------FAEQLLDKKKLKASNVPPVRLL--LEDMR----LR-KPKKVVNQLVLPSSLKNKNTFK 422
                   ..|:|.::|.||.:.:.|..:|  ||..|    || |.|.:.::.:|
  Rat   297 GSSEVSLVCEKLSNEKLLKKARIHPFHVLTALETYRTGHGLRGKLKWIPDKEIL----------- 350

  Fly   423 FQCATTSFQKASFLHSVYEISFGLNKALGRR----LHITLNLEQAYLGKYLSGPCRSLKYLDALV 483
             |....:|.|          :|...:..|:|    :.::.:::|..||..|:..       ....
  Rat   351 -QALDAAFYK----------TFKTVEPTGKRFLLAVDVSGSMDQRVLGSVLNAS-------TVAA 397

  Fly   484 ALGFGYFRSDRKVT-VEFWHDRSGKLKALPWTNEMSVSEAKTCCENQKVGKVRQSLNEILFRALL 547
            |:.....|::::.: |.|..|    :...|.|.:|::.:..|.......|....||      .::
  Rat   398 AMCMVVTRTEKESSVVAFACD----MVPFPVTTDMTLQQVLTAMNKVPAGTTDCSL------PMI 452

  Fly   548 DMQNT---FDVFLVLVPG---AARGNPENNSKCLAALMDKYREKRNSNAKFIMVSLRQRQRSMIY 606
            ..|.|   .|||:|....   |.:.:|       |..:.:||:|....||.::..:  .......
  Rat   453 WAQKTGTAADVFIVFTDNETFAGQVHP-------AIALREYRKKMAIPAKLLVCGM--TSNGFTI 508

  Fly   607 SSGRNENLLELCSLDKHTPRLINAF 631
            :...:..:|::|..|.....:|..|
  Rat   509 ADPDDRGMLDMCGFDTAALDVIRNF 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10803	NP_570064.1	TROVE	<197..394	CDD:283406	50/222 (23%)
Ro60	NP_001100653.1	TROVE	16..369	CDD:283406	86/399 (22%)
Ro60	NP_001100653.1	vWFA	372..489	CDD:238119	27/140 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353427
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4465
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	53	1.000	Inparanoid score	I5349
OMA	1	1.010	-	-		QHG59608
OrthoDB	1	1.010	-	-		D223041at33208
OrthoFinder	1	1.000	-	-		FOG0007329
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107029
Panther	1	1.100	-	-	LDO	PTHR14202
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.770