Protein Alignment CG10803 and Ro60

DIOPT Version :10

• Sequence 1: NP_570064.1
• Gene: CG10803 / 31320
• FlyBaseID: FBgn0029666
• Length: 637
• Species: Drosophila melanogaster
• Sequence 2: NP_038863.1
• Gene: Ro60 / 20822
• MGIID: 106652
• Length: 538
• Species: Mus musculus
• Alignment Length: 616
• Identity: 134/616 - (21%)
• Similarity: 245/616 - (39%)
• Gaps: 131/616 - (21%)

  Fly    64 MEKEAISNQPLKDEPSKDEPNQSEGTAISTIPAIDKLRRFCFIGSTDEPVYTTPALDLVVENNFA 128
            ||..|...|||    |:.:...|||..:..:..:::||||...|| :...|......|.:||
Mouse     1 MEGSANQLQPL----SETQVVNSEGGCVWQVTDMNRLRRFLCFGS-EGGTYYIKEQKLGLEN--- 57

  Fly   129 SLKELCSQVSED----ELVECLLSVLGSEPNEEQPPRPDEPLLILAVFFTTCEDEKKRNAVRNRF 189
              .|...::.||    |:::.:.|.     ::|......||||......:.|.|...:.|.....
Mouse    58 --AEALIRLIEDGRGCEVIQEIKSF-----SQEGRTAKQEPLLFALAVCSQCADINTKQAAFKAV 115

  Fly   190 TDLITSESDLLLFVQLVKRVQKLLERKTPFNRTVRKAVLNWYGTK-SLDRLLHFWSIGDGNRWPA 253
            .::....:.|..|:|..|.:::.: :...:.|.:||||.:||..| .:...|........|.| :
Mouse   116 PEVCRIPTHLFTFIQFKKDLKESM-KCGMWGRALRKAVADWYNEKGGMAVALVVTKYKQRNGW-S 178

  Fly   254 HRDLLYRLHFRHANFLPEIIAAL-RLLSSSPKELSQWPDFLTPLTSFRE---TIEGVVKLRLLTD 314
            |:|||...|.:.::   |.:|.: :.::...||:.:         .::|   ::|....|:.|
Mouse   179 HKDLLRLSHLKPSS---EGLAIVTKYITKGWKEVHE---------EYKEKALSVEAEKLLKYL-- 229

  Fly   315 PEQAISIVKKLSLSWEHVPFHLLHDPRLA--HFLIPHMS----YEQLLQKWPRLSRL-------- 365
              :|:..||:.....|.:  ||:.:.:|.  |.|..|:.    ::.|||:.|..:.|
Mouse   230 --EAVEKVKRTKDDLEVI--HLIEEHQLVREHLLTNHLKSKEVWKALLQEMPLTALLRNLGKMTA 290

  Fly   366 -------NSRVRPFAEQLLDKKKLKASNVPPVRLL--LEDMR----LR-KPKKVVNQLVLPSSLK 416
                   ||.|....|:|.::|.||.:.:.|..:|  ||..|    || |.|.:.::.:|.:
Mouse   291 NSVLEPGNSEVSLICEKLSNEKLLKKARIHPFHVLIALETYRAGHGLRGKLKWIPDKDILQA--- 352

  Fly   417 NKNTFKFQCATTSFQKASFLHSVYEISFGLNKALGRR----LHITLNLEQAYLGKYLSGPCRSLK 477
                               |.:.:..:|...:..|:|    :.::.::.|..||..|:..
Mouse   353 -------------------LDAAFYTTFKTVEPTGKRFLLAVDVSASMNQRALGSVLNAS----- 393

  Fly   478 YLDALVALGFGYFRSDRKVT-VEFWHDRSGKLKALPWTNEMSVSEAKTCCENQKVGKVRQSLNEI 541
              ....|:.....|::::.: |.|..|    :...|.|.:|::.:..|.......|....||
Mouse   394 --TVAAAMCMVVTRTEKESSVVAFACD----MVPFPVTTDMTLQQVLTAMNKVPAGNTDCSL--- 449

  Fly   542 LFRALLDMQNT---FDVFLVLVPG---AARGNPENNSKCLAALMDKYREKRNSNAKFIMVSLRQR 600
               .::..|.|   .|||:|....   |.:.:|       |..:.:||:|.:..||.|:..:  .
Mouse   450 ---PMIWAQKTDTAADVFVVFTDNETFAGQVHP-------AVALREYRKKMDIPAKLIVCGM--T 502

  Fly   601 QRSMIYSSGRNENLLELCSLDKHTPRLINAF 631
            ......:...:..:|::|..|.....:|..|
Mouse   503 SNGFTIADPDDRGMLDMCGFDTAALDVIRNF 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10803	NP_570064.1	TROVE	<197..394	CDD:461724	53/224 (24%)
Ro60	NP_038863.1	TROVE	16..369	CDD:461724	89/405 (22%)
		RNA-binding. /evidence=ECO:0000250|UniProtKB:P42700	120..284		43/183 (23%)
		VWFA-like domain. /evidence=ECO:0000250|UniProtKB:P42700	361..538		39/199 (20%)
		ViaA	<363..489	CDD:441973	29/149 (19%)