Protein Alignment CG10804 and slc6a3

DIOPT Version :10

• Sequence 1: NP_001138150.1
• Gene: CG10804 / 31317
• FlyBaseID: FBgn0029663
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_571830.1
• Gene: slc6a3 / 80787
• ZFINID: ZDB-GENE-010316-1
• Length: 629
• Species: Danio rerio
• Alignment Length: 683
• Identity: 254/683 - (37%)
• Similarity: 355/683 - (51%)
• Gaps: 97/683 - (14%)

  Fly    32 LRGR-LVSKEHGVSHHHHTSLHHQPLYGATNQGFMSDAFDESSEL----EQDPPPFGSEASTSKA 91
            |||| .|:.....:|.|.:|:          .|..|.|.....||    ||:...|.|.:..:..
Zfish     4 LRGRPAVTHTRTRTHTHMSSV----------SGSSSAAGPREVELVLVKEQNGVQFTSSSLRNPG 58

  Fly    92 KAELVAIATASADQQDIVEGEKEGEERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAF 156
                     |.:...........|::||:|..||.|||:.||:||.|.||||||||..|||||||
Zfish    59 ---------AHSHTHTHTHTHPSGQQRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAF 114

  Fly   157 LVPYFIMLCIQGIPIFYLELAIGQRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAW 221
            ||||.:.:.|.|:|:||:|||:||..|:||.||| ::.|...|:|.:..::|..|..|||.||||
Zfish   115 LVPYLLFMVIAGMPLFYMELALGQYNREGAAGVW-KICPIFKGVGFTVILISLYVGSYYNVIIAW 178

  Fly   222 CLIYLLHSFESPLPWADC-----------PTRLYKNFTYDHEPECVASSPTQFYWYRTTLQCSES 275
            .|.||..||...|||..|           |.....|.||       .::|...|:.|..|...||
Zfish   179 ALFYLFSSFSGELPWIHCNNTWNSPNCSDPNATLLNDTY-------KTTPALEYFERGVLHVHES 236

  Fly   276 --VDMPENFNYHMAIALIVSWFLVYICMVQGITSSGKIVYMTAIFPYVVLIIFFFRGITLKGAAD 338
              :|......:.:...|.|...::|..:.:|:.:|||:|::||..|||||.:...||:||.||.|
Zfish   237 SGIDDLGAPRWQLTACLAVVIVVLYFSLWKGVKTSGKVVWITATMPYVVLTVLLLRGVTLPGAID 301

  Fly   339 GVAHLFTPRWETLLDPVVWLEAGTQIFFSLGLAFGGLIAFSSYNPANNNCYRDAILVSLTNCGTS 403
            |:....:..:..|.|..||:||.|||.||||:.||.||||||||..:||||||||:.|..|..||
Zfish   302 GIKAYLSVDFLRLYDAQVWIEAATQICFSLGVGFGVLIAFSSYNKFSNNCYRDAIITSSINSLTS 366

  Fly   404 MFAGVVVFSVIGFKATATFDRCTEERNGLVAQNKTHNLPVCDLQTELANSASGTGLAFIIFTEAI 468
            .|:|.|:||.:|:                  .::.||:.:..:.|:      |.||.|||:.|||
Zfish   367 FFSGFVIFSFLGY------------------MSQKHNVALDKVATD------GPGLVFIIYPEAI 407

  Fly   469 NQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGVVTSLVDMKLFPNLPKEYIVGALCFSCCTISM-C 532
            ...||:.:|||:||:||.||||||..|.:|.|:|.|:|...|.:..:|.....:..|...||: |
Zfish   408 ATLPGSSVWAVIFFIMLLTLGIDSAMGGMESVITGLIDEFKFLHKHRELFTLFIVVSTFLISLIC 472

  Fly   533 FANGAGSYIFQLMDSFAGNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYWMFCWKYL 597
            ..|| |.|:|.|:|.||....:|...|.|.:.|::.|||.|||||||.|.|.||..||..|||::
Zfish   473 VTNG-GIYVFTLLDHFAAGTSILFGVLIEAIGIAWFYGVDRFSDDIEEMIGQRPGLYWRLCWKFV 536

  Fly   598 SPCAMVTILLASF--YQLLTEGSSYPAWIGSKGATEGMEWPHWCIVVAFFLILSSILWIPIVAVL 660
            |||.::.:::.||  :.....||.|              :|.|..:|.:.|.:||::.:|:.|..
Zfish   537 SPCFLLFMVVVSFATFNPPKYGSYY--------------FPTWATMVGWCLSISSMIMVPLYAFY 587

  Fly   661 RLCGI----------KVVEDSDPAWFPEAELRE 683
            :.|.:          .:..::|.......|:|:
Zfish   588 KFCSLPGSFCDKLAYAITPETDHHLVERGEVRQ 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	229/556 (41%)
slc6a3	NP_571830.1	SLC6sbd_DAT1	76..623	CDD:212083	235/592 (40%)