DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10804 and Slc6a19

DIOPT Version :9

Sequence 1:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_083154.1	Gene:	Slc6a19 / 74338	MGIID:	1921588	Length:	634	Species:	Mus musculus

Alignment Length:	622	Identity:	266/622 - (42%)
Similarity:	373/622 - (59%)	Gaps:	53/622 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 SADQQDIVEGEKEGEERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCI 166
            |.|:.:::|.|:.| .|..||:|..::|..:|:.||||||||||||.|.:|||||::|:.|:|..
Mouse    17 SLDELEVIEKEEAG-SRPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVF 80

  Fly   167 QGIPIFYLELAIGQRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFE 231
            :|||:.|||.|||||||||::||||.:.|.|.||||:|..||::|.|||||||||.:.|..:||:
Mouse    81 EGIPLLYLEFAIGQRLRKGSMGVWSSIHPALKGIGIASMFVSFMVGLYYNTIIAWVMWYFFNSFQ 145

  Fly   232 SPLPWADCPTRLYKNFTYDHEPECVASSPTQFYWYRTTLQCSESVDMPENFNYHMAIALIVSWFL 296
            .||||::||  |.:|.| .:..||..||...::|||.||..|.|:....:..:.:.:.|..:|.:
Mouse   146 EPLPWSECP--LNQNQT-GYVEECAKSSSVDYFWYRETLNISTSISDSGSIQWWILLCLTCAWSV 207

  Fly   297 VYICMVQGITSSGKIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLDPVVWLEAG 361
            :|:|:::||.::||.||:|:..|||||.||..||:|||||.:|:..||||....|.:|..||:||
Mouse   208 LYVCIIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNITELSNPNTWLDAG 272

  Fly   362 TQIFFSLGLAFGGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFKATATFDRC- 425
            .|:|:|..|||||||:|||||..:|||..|:::||:.|..||::|..||:|:|||:||..||.|
Mouse   273 AQVFYSFSLAFGGLISFSSYNSVHNNCEMDSVIVSVINGFTSVYAATVVYSIIGFRATERFDDCV 337

  Fly   426 ------------------TEERNGLVAQ--NKTH-------NLPVCDLQTELANSASGTGLAFII 463
                              |.|......|  |.|:       ....||:.:.|:....|||||||:
Mouse   338 NTNILTLINGFDLPEGNVTSENFEAYQQWCNATNPQAYAQLKFQTCDINSFLSEGVEGTGLAFIV 402

  Fly   464 FTEAINQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGVVTSLVDMKLFP-NLPKEYIVGALCFSCC 527
            |||||.:.|.:.||:||||:|||.||:.|.||.:||||..|.|:.:.| ..|||.:.|.:|....
Mouse   403 FTEAITKMPVSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLNITPKKWPKELLTGLICLGTY 467

  Fly   528 TISMCFANGAGSYIFQLMDSFAGNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYWMF 592
            .|:..|...:|.|...|:|||||:.||||||..|..::.|:|||.||:.|||.|.|.:||.:|..
Mouse   468 LIAFIFTLNSGQYWLSLLDSFAGSIPLLIIAFCEMFAVVYVYGVDRFNKDIEFMIGHKPNIFWQV 532

  Fly   593 CWKYLSPCAMVTILLASFYQLLTEGSSYPAW---IGSKGATEGMEWPHWCIVVAFFLILSSILWI 654
            .|:.:||..|:.|.|..|...:.:...|..|   ......::.:.:|:|...|...:.....|.|
Mouse   533 TWRVVSPLIMLVIFLFFFVIEVNKTLMYSIWDPNYEEFPKSQKIPYPNWVYAVVVTVAGVPCLSI 597

  Fly   655 PIVAV---LRLCGIKVVEDSDPAWFPEAELREVHGIV 688
            |..|:   :|.|    .:.||          :.||:|
Mouse   598 PCFAIYKFIRNC----CQKSD----------DHHGLV 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	253/575 (44%)
Slc6a19	NP_083154.1	SLC5-6-like_sbd	32..612	CDD:294310	256/586 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48419
OrthoDB	1	1.010	-	-		D251682at33208
OrthoFinder	1	1.000	-	-		FOG0001784
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101967
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4904
SonicParanoid	1	1.000	-	-		X2259
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.860