DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10804 and Slc6a19

DIOPT Version :9

Sequence 1:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001034811.2	Gene:	Slc6a19 / 664630	RGDID:	1594328	Length:	634	Species:	Rattus norvegicus

Alignment Length:	595	Identity:	260/595 - (43%)
Similarity:	369/595 - (62%)	Gaps:	40/595 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 SADQQDIVEGEKEGEERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCI 166
            |.|:.:::|.| |...|..||:|..::|..:|:.||||||||||||.|.:|||||::|:.|:|.:
  Rat    17 SLDELEVIEKE-EASSRPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVL 80

  Fly   167 QGIPIFYLELAIGQRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFE 231
            :|||:.:||.|||||||||::||||.:.|.|.|:||:|..||::|.|||||||||.:.|..:||:
  Rat    81 EGIPLLHLEFAIGQRLRKGSVGVWSSIHPALKGVGIASMFVSFMVGLYYNTIIAWVMWYFFNSFQ 145

  Fly   232 SPLPWADCPTRLYKNFTYDHEPECVASSPTQFYWYRTTLQCSESVDMPENFNYHMAIALIVSWFL 296
            .||||::||  |.:|.| .:..||..||...::|||.||..|.|:....:..:.:.:.|..:|.:
  Rat   146 EPLPWSECP--LNQNQT-GYVEECAKSSSVDYFWYRETLNISTSISDSGSIQWWILLCLTCAWSV 207

  Fly   297 VYICMVQGITSSGKIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLDPVVWLEAG 361
            :|:|.::||.::||.||:|:..|||||.||..||:|||||.:|:..||||....|.:|..||:||
  Rat   208 LYVCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNITELSNPNTWLDAG 272

  Fly   362 TQIFFSLGLAFGGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFKATATFDRCT 426
            .|:|:|..|||||||:|||||..:|||..|:::||:.|..||::|..||:|:|||:||..||.|.
  Rat   273 AQVFYSFSLAFGGLISFSSYNSVHNNCEMDSVIVSIINGFTSVYAATVVYSIIGFRATERFDDCV 337

  Fly   427 EER-----NG-------LVAQ---------NKTH-------NLPVCDLQTELANSASGTGLAFII 463
            ...     ||       :.|:         |.|:       ....||:.|.|:....|||||||:
  Rat   338 NTNILTLINGFDLPEGNVTAENFEAYQHWCNATNPEAYAQLTFQTCDINTFLSEGVEGTGLAFIV 402

  Fly   464 FTEAINQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGVVTSLVDMKLFP-NLPKEYIVGALCFSCC 527
            |||||.:.|.:.||:||||:|||.||:.|.||.:||||..|.|:.:.| ..|||.:.|.:|....
  Rat   403 FTEAITKMPVSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLNITPKKWPKELLTGLICLGTY 467

  Fly   528 TISMCFANGAGSYIFQLMDSFAGNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYWMF 592
            .|:..|...:|.|...|:||:||:.||||||..|..::.|:|||.||:.|||.|.|.:||.:|..
  Rat   468 LIAFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFAVVYVYGVDRFNKDIEFMIGHKPNIFWQV 532

  Fly   593 CWKYLSPCAMVTILLASFYQLLTEGSSYPAW---IGSKGATEGMEWPHWCIVVAFFLILSSI--L 652
            .|:.:||..|:.|.|..|...:.:...|..|   ......::.:.:|.|  |.|..:|::.:  |
  Rat   533 TWRVVSPLIMLVIFLFFFVIEVNKQLMYSVWDPDYEEFPKSQKVPYPDW--VYAVVVIVAGVPCL 595

  Fly   653 WIPIVAVLRL 662
            .||..|:.:|
  Rat   596 TIPCFAIYKL 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	253/574 (44%)
Slc6a19	NP_001034811.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48419
OrthoDB	1	1.010	-	-		D251682at33208
OrthoFinder	1	1.000	-	-		FOG0001784
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101967
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2259
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.830