Protein Alignment CG10804 and SLC6A12

DIOPT Version :10

• Sequence 1: NP_001138150.1
• Gene: CG10804 / 31317
• FlyBaseID: FBgn0029663
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_003035.3
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 214/589 - (36%)
• Similarity: 314/589 - (53%)
• Gaps: 86/589 - (14%)

  Fly   104 DQQDIVEGEKEGEERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQG 168
            ||:|    |.:.::|..|.:|:.|:|:..|..:|||||||||||..|||||||.:||||...:.|
Human    26 DQED----EDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCG 86

  Fly   169 IPIFYLELAIGQRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESP 233
            ||:|:||:|:||...:|::..|.::.|...|||::|.|:...:.:||..|:||.|.||..||.|.
Human    87 IPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSE 151

  Fly   234 LPWADC-------------------PTRLYKNFTYDHEPECVASSPTQFYWYRTTLQCSESVDMP 279
            |||..|                   ....::|||          ||...:|.|..|..:..:...
Human   152 LPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFT----------SPVMEFWERRVLGITSGIHDL 206

  Fly   280 ENFNYHMAIALIVSWFLVYICMVQGITSSGKIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLF 344
            .:..:.:|:.|:::|.:.|.|:.:|:.|:||:||.||.|||::|:|...||:||.||..|:.:..
Human   207 GSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYL 271

  Fly   345 TPRWETLLDPVVWLEAGTQIFFSLGLAFGGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVV 409
            .|....|.||.||::||||||||..:..|.|.|..|||..:||||:|.|.:...|..||..||.|
Human   272 KPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFV 336

  Fly   410 VFSVIGFKATATFDRCTEERNGLVAQNKTHNLPVCDLQTELANSASGTGLAFIIFTEAINQFPGA 474
            |||::||                  .::...:|:.::      :.||.|||||.|.:|:...|.:
Human   337 VFSILGF------------------MSQEQGVPISEV------AESGPGLAFIAFPKAVTMMPLS 377

  Fly   475 QLWAVLFFLMLFTLGIDSQFGTLEGVVTSLVDMKLFPNL-----PKEYIVGALCFSCCTISMCFA 534
            |||:.|||:||..||:||||..:|.:||:.:||  ||..     .:|.::..:...|..|.:...
Human   378 QLWSCLFFIMLIFLGLDSQFVCVECLVTASIDM--FPRQLRKSGRRELLILTIAVMCYLIGLFLV 440

  Fly   535 NGAGSYIFQLMDSFAGN-FPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYW---MFCWK 595
            ...|.|||||.|.:|.: ..||.::|||.:.||::||..||.|:||.|.|.||   |   ...|.
Human   441 TEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRP---WPLVKISWL 502

  Fly   596 YLSP--CAMVTILLASFYQLLTEGSSYPAWIGSKGATEGMEWPHWCIVVAFFLILSSILWIPIVA 658
            :|:|  |....:...|.|..|...:.|             .:|.|...:.:||.|||::.:|:..
Human   503 FLTPGLCLATFLFSLSKYTPLKYNNVY-------------VYPPWGYSIGWFLALSSMVCVPLFV 554

  Fly   659 VLRL 662
            |:.|
Human   555 VITL 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	208/570 (36%)
SLC6A12	NP_003035.3	SLC6sbd_BGT1	35..575	CDD:212080	210/576 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614