Protein Alignment CG10804 and SLC6A3

DIOPT Version :10

• Sequence 1: NP_001138150.1
• Gene: CG10804 / 31317
• FlyBaseID: FBgn0029663
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_001035.1
• Gene: SLC6A3 / 6531
• HGNCID: 11049
• Length: 620
• Species: Homo sapiens
• Alignment Length: 651
• Identity: 235/651 - (36%)
• Similarity: 339/651 - (52%)
• Gaps: 91/651 - (13%)

  Fly    87 STSKAKAELVAIATASADQQDIVEGEK----------------------------EGEERESWDS 123
            |.||....|::...|.|.:.:.| |.|                            |.::||:|..
Human     2 SKSKCSVGLMSSVVAPAKEPNAV-GPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGK 65

  Fly   124 KIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIFYLELAIGQRLRKGAIG 188
            ||.|||:.||:||.|.||||||||..|||||||||||.:.:.|.|:|:||:|||:||..|:||.|
Human    66 KIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAG 130

  Fly   189 VWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPLPWADCPTRLYKNFTYDHEP 253
            || ::.|.|.|:|.:..::|..|..:||.||||.|.||..||.:.|||..|..........|..|
Human   131 VW-KICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHP 194

  Fly   254 -----------ECVASSPTQFYWYRTTLQCSES--VDMPENFNYHMAIALIVSWFLVYICMVQGI 305
                       :...::|...|:.|..|...:|  :|......:.:...|::...|:|..:.:|:
Human   195 GDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGV 259

  Fly   306 TSSGKIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLDPVVWLEAGTQIFFSLGL 370
            .:|||:|::||..|||||.....||:||.||.||:....:..:..|.:..||::|.||:.||||:
Human   260 KTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGV 324

  Fly   371 AFGGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFKATATFDRCTEERNGLVAQ 435
            .||.||||||||...||||||||:.:..|..||..:|.||||.:|:.|
Human   325 GFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMA----------------- 372

  Fly   436 NKTHNLPVCDLQTELANSASGTGLAFIIFTEAINQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGV 500
             :.|::|:.|:      :..|.||.|||:.|||...|.:..|||:||:||.||||||..|.:|.|
Human   373 -QKHSVPIGDV------AKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESV 430

  Fly   501 VTSLVDMKLFPNLPKEYIVGALCFSCCTISM-CFANGAGSYIFQLMDSFAGNFPLLIIALFECLS 564
            :|.|:|.....:..:|.....:..:...:|: |..|| |.|:|.|:|.||....:|...|.|.:.
Human   431 ITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNG-GIYVFTLLDHFAAGTSILFGVLIEAIG 494

  Fly   565 ISYIYGVRRFSDDIEMMTGSRPNFYWMFCWKYLSPCAMVTILLASFYQLLTEGSSYPAWIGSKGA 629
            :::.|||.:|||||:.|||.||:.||..|||.:|||.::.:::.|.  :......|.|:|
Human   495 VAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI--VTFRPPHYGAYI----- 552

  Fly   630 TEGMEWPHWCIVVAFFLILSSILWIPIVAVLRLCGIKVVEDSDPAWFPEAELREVHGIVPHEPTE 694
                 :|.|...:.:.:..||:..:||.|..:.|.:       |..|.|   :..:.|.|.:..|
Human   553 -----FPDWANALGWVIATSSMAMVPIYAAYKFCSL-------PGSFRE---KLAYAIAPEKDRE 602

  Fly   695 L 695
            |
Human   603 L 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	215/554 (39%)
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	225/592 (38%)
		Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:12177201	561..590		9/38 (24%)