DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10804 and SLC6A3

DIOPT Version :9

Sequence 1:NP_001138150.1 Gene:CG10804 / 31317 FlyBaseID:FBgn0029663 Length:726 Species:Drosophila melanogaster
Sequence 2:NP_001035.1 Gene:SLC6A3 / 6531 HGNCID:11049 Length:620 Species:Homo sapiens


Alignment Length:651 Identity:235/651 - (36%)
Similarity:339/651 - (52%) Gaps:91/651 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 STSKAKAELVAIATASADQQDIVEGEK----------------------------EGEERESWDS 123
            |.||....|::...|.|.:.:.| |.|                            |.::||:|..
Human     2 SKSKCSVGLMSSVVAPAKEPNAV-GPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGK 65

  Fly   124 KIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIFYLELAIGQRLRKGAIG 188
            ||.|||:.||:||.|.||||||||..|||||||||||.:.:.|.|:|:||:|||:||..|:||.|
Human    66 KIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAG 130

  Fly   189 VWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPLPWADCPTRLYKNFTYDHEP 253
            || ::.|.|.|:|.:..::|..|..:||.||||.|.||..||.:.|||..|..........|..|
Human   131 VW-KICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHP 194

  Fly   254 -----------ECVASSPTQFYWYRTTLQCSES--VDMPENFNYHMAIALIVSWFLVYICMVQGI 305
                       :...::|...|:.|..|...:|  :|......:.:...|::...|:|..:.:|:
Human   195 GDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGV 259

  Fly   306 TSSGKIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLDPVVWLEAGTQIFFSLGL 370
            .:|||:|::||..|||||.....||:||.||.||:....:..:..|.:..||::|.||:.||||:
Human   260 KTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGV 324

  Fly   371 AFGGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFKATATFDRCTEERNGLVAQ 435
            .||.||||||||...||||||||:.:..|..||..:|.||||.:|:.|                 
Human   325 GFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMA----------------- 372

  Fly   436 NKTHNLPVCDLQTELANSASGTGLAFIIFTEAINQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGV 500
             :.|::|:.|:      :..|.||.|||:.|||...|.:..|||:||:||.||||||..|.:|.|
Human   373 -QKHSVPIGDV------AKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESV 430

  Fly   501 VTSLVDMKLFPNLPKEYIVGALCFSCCTISM-CFANGAGSYIFQLMDSFAGNFPLLIIALFECLS 564
            :|.|:|.....:..:|.....:..:...:|: |..|| |.|:|.|:|.||....:|...|.|.:.
Human   431 ITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNG-GIYVFTLLDHFAAGTSILFGVLIEAIG 494

  Fly   565 ISYIYGVRRFSDDIEMMTGSRPNFYWMFCWKYLSPCAMVTILLASFYQLLTEGSSYPAWIGSKGA 629
            :::.|||.:|||||:.|||.||:.||..|||.:|||.::.:::.|.  :......|.|:|     
Human   495 VAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI--VTFRPPHYGAYI----- 552

  Fly   630 TEGMEWPHWCIVVAFFLILSSILWIPIVAVLRLCGIKVVEDSDPAWFPEAELREVHGIVPHEPTE 694
                 :|.|...:.:.:..||:..:||.|..:.|.:       |..|.|   :..:.|.|.:..|
Human   553 -----FPDWANALGWVIATSSMAMVPIYAAYKFCSL-------PGSFRE---KLAYAIAPEKDRE 602

  Fly   695 L 695
            |
Human   603 L 603

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10804NP_001138150.1 SLC6sbd-B0AT-like 120..661 CDD:271364 215/554 (39%)
SLC6A3NP_001035.1 SLC6sbd_DAT1 60..614 CDD:212083 225/592 (38%)
Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:12177201 561..590 9/38 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0733
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.