Protein Alignment CG10804 and SLC6A2

DIOPT Version :9

• Sequence 1: NP_001138150.1
• Gene: CG10804 / 31317
• FlyBaseID: FBgn0029663
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_001165975.1
• Gene: SLC6A2 / 6530
• HGNCID: 11048
• Length: 628
• Species: Homo sapiens
• Alignment Length: 652
• Identity: 231/652 - (35%)
• Similarity: 343/652 - (52%)
• Gaps: 93/652 - (14%)

  Fly    89 SKAKAELVAIATASADQQDIVEGEKEGEERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGG 153
            ::..|||:.:...:..|..:...:.:.:.||:|..||.|||:.:|:||.|.||||||||..||||
Human    27 ARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGG 91

  Fly   154 GAFLVPYFIMLCIQGIPIFYLELAIGQRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTI 218
            ||||:||.:.|.|.|:|:||:|||:||..|:||..|| ::.|:..|:|.:..:::..|..|||.|
Human    92 GAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVW-KICPFFKGVGYAVILIALYVGFYYNVI 155

  Fly   219 IAWCLIYLLHSFESPLPWADCPTRLYKNFTYDHEPEC---------VASSPTQFYWYRTT----- 269
            |||.|.||..||...|||.||      ..|: :.|.|         |..:.|::..|:.|
Human   156 IAWSLYYLFSSFTLNLPWTDC------GHTW-NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEF 213

  Fly   270 -----LQCSES-----VDMPENFNYHMAIALIVSWFLVYICMVQGITSSGKIVYMTAIFPYVVLI 324
                 |...||     :.:|:   :.:.:.|:|...::|..:.:|:.:|||:|::||..||.||.
Human   214 YERGVLHLHESSGIHDIGLPQ---WQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLF 275

  Fly   325 IFFFRGITLKGAADGVAHLFTPRWETLLDPVVWLEAGTQIFFSLGLAFGGLIAFSSYNPANNNCY 389
            :....|:||.||::|:.......:..|.:..||::|.||||||||..||.||||:|||..:||||
Human   276 VLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCY 340

  Fly   390 RDAILVSLTNCGTSMFAGVVVFSVIGFKATATFDRCTEERNGLVAQNKTHNLPVCDLQTELANSA 454
            |||:|.|..||.||..:|..:||::|:.|                  ..|.:.:.|:.||
Human   341 RDALLTSSINCITSFVSGFAIFSILGYMA------------------HEHKVNIEDVATE----- 382

  Fly   455 SGTGLAFIIFTEAINQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGVVTSLV-DMKLFPNLPKEYI 518
             |.||.||::.|||:...|:..|||:||:||..||:||..|.:|.|:|.|. |.::.....|.:.
Human   383 -GAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFT 446

  Fly   519 VGALCFSCCTISM-CFANGAGSYIFQLMDSFAGNFPLLIIALFECLSISYIYGVRRFSDDIEMMT 582
            .| :.||...::: |...| |.|:..|:|:||....:|...|.|.:.:|:.|||.|||:||:.|.
Human   447 FG-VTFSTFLLALFCITKG-GIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMM 509

  Fly   583 GSRPNFYWMFCWKYLSPCAMVTILLAS---FYQLLTEGSSYPAWIGSKGATEGMEWPHWCIVVAF 644
            |.||..||..|||::||..::.:::.|   |..|..:...:|.|         ..|..|.|.
Human   510 GFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPW---------ANWVGWGIA--- 562

  Fly   645 FLILSSILWIPIVAVLRLCGIKVVEDSDPAWFPEAELREVHGIVPHEPTEL--ERSIFCFNMDGT 707
               |||::.:||..:     .|.:......|     .|..:||.|.....|  :|.|..|.|...
Human   563 ---LSSMVLVPIYVI-----YKFLSTQGSLW-----ERLAYGITPENEHHLVAQRDIRQFQMKTR 614

  Fly   708 EG 709
            :|
Human   615 QG 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	213/569 (37%)
SLC6A2	NP_001165975.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		SLC6sbd_NET	56..612	CDD:212081	225/617 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810