Protein Alignment CG10804 and SLC6A1

DIOPT Version :10

• Sequence 1: NP_001138150.1
• Gene: CG10804 / 31317
• FlyBaseID: FBgn0029663
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Alignment Length: 609
• Identity: 239/609 - (39%)
• Similarity: 351/609 - (57%)
• Gaps: 73/609 - (11%)

  Fly    59 ATNQGFMSDAFDESSELEQDPPPFGSEASTSKAKAELVAIATASADQQDIVEGEKEGEERESWDS 123
            |||...::|. ..|:|:.:.|      .:..|.|..:|.:...:||..|          |::|..
Human     2 ATNGSKVADG-QISTEVSEAP------VANDKPKTLVVKVQKKAADLPD----------RDTWKG 49

  Fly   124 KIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIFYLELAIGQRLRKGAIG 188
            :..||::.:|||:|||||||||||..||||||||:|||:.|...|:|:|.||.::||....|.:|
Human    50 RFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLG 114

  Fly   189 VWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPLPWADCPT-----RLYKNFT 248
            || :::|...|:|:::||:|:.:.:||..||:|.:.||.:||.:.|||..|..     |.:.|::
Human   115 VW-KLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYS 178

  Fly   249 YDHEPECVASSPTQFYWYRTTLQCSESVDMPENFNYHMAIALIVSWFLVYICMVQGITSSGKIVY 313
            ..:... :.|:..:| |.|...|.::.:|.|....:.:||.|.::|.|||.|:.:|:..:||:||
Human   179 MVNTTN-MTSAVVEF-WERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVY 241

  Fly   314 MTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLDPVVWLEAGTQIFFSLGLAFGGLIAF 378
            .:|.:||::|||.||||:||.||.:|:....||.:..|.|..|||:|.||||||.||..|.|||.
Human   242 FSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIAL 306

  Fly   379 SSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFKATATFDRCTEERNGLVAQNKTHNLPV 443
            .|||..:||.|||:|:|...|..||||||.|:||::||.|..|      :|:            :
Human   307 GSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVT------KRS------------I 353

  Fly   444 CDLQTELANSASGTGLAFIIFTEAINQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGVVTSLVDMK 508
            .|:      :|||.||||:.:.||:.|.|.:.|||:|||.||..|||||||.|:||.:|:|||.
Human   354 ADV------AASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDE- 411

  Fly   509 LFPNL---PKEYIVGALCFSCCTISMCFANGAGSYIFQLMDSF-AGNFPLLIIALFECLSISYIY 569
             :|.|   .:|..:.|:|.....|.:......|.|:|:|.|.: |....||.:..|||:|||:.|
Human   412 -YPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFY 475

  Fly   570 GVRRFSDDIEMMTGSRPNFYWMFCWKYLSPCAMVTILLASFYQL--LTEGS-SYPAWIGSKGATE 631
            ||.||.|:|:.|.||||..:|..||.:.:|..:..:.:.|..|:  ||.|: .:|.|      .:
Human   476 GVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKW------GQ 534

  Fly   632 GMEWPHWCIVVAFFLILSSILWIP 655
            |:.|         .:.|||::.||
Human   535 GVGW---------LMALSSMVLIP 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	225/548 (41%)
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	239/609 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599