DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10804 and slc6a1l

DIOPT Version :9

Sequence 1:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	XP_021330952.1	Gene:	slc6a1l / 568985	ZFINID:	ZDB-GENE-041210-296	Length:	578	Species:	Danio rerio

Alignment Length:	573	Identity:	228/573 - (39%)
Similarity:	321/573 - (56%)	Gaps:	58/573 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 AIATASADQQDIVEGEKEGE--ERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVP 159
            ||.....|...|...|||.:  :|.||..|..|||:.:|||:|||||||||||..||||||||:|
Zfish     4 AIPFEDLDHNSIPVEEKENKIPDRGSWKGKFDFLLSCVGYAIGLGNVWRFPYLCGKNGGGAFLIP 68

  Fly   160 YFIMLCIQGIPIFYLELAIGQRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLI 224
            ||..|...|||:|.||.|:||....|.:|||..: |.:.|:|:::.|:|:.:.:||..||||.|.
Zfish    69 YFTTLVFAGIPLFLLETALGQYTSVGGLGVWKLI-PMMKGVGLAAVVLSFWLNIYYIIIIAWALY 132

  Fly   225 YLLHSFESPLPWADCPT-----RLYKNFTYDHEPECVASSPTQFYWYRTTLQCSESVDMPENFNY 284
            ||..|.::.|||..|..     |.:.|::. .:...::|:.|:| |.|...|.:..::.|....:
Zfish   133 YLFSSLKAELPWQTCDNPWNTDRCFSNYSL-LDTTNLSSAVTEF-WERNMHQLTNGLEEPGELRW 195

  Fly   285 HMAIALIVSWFLVYICMVQGITSSGKIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWE 349
            .:...|.:||.|||..:.:|:..:||:||.:|.:||.:|.|.||||:||.||.|||....||.:.
Zfish   196 PLVGTLALSWILVYFSIWKGVEWTGKVVYFSATYPYFMLFILFFRGVTLPGAIDGVLFYITPNFN 260

  Fly   350 TLLDPVVWLEAGTQIFFSLGLAFGGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVI 414
            .||...|||:|.||||||.||..|.|||..|||..|||.|||:::|...|..||||||:|:||::
Zfish   261 KLLKSEVWLDAATQIFFSYGLGLGSLIALGSYNSFNNNVYRDSVIVCCINSCTSMFAGIVIFSIV 325

  Fly   415 GFKATATFDRCTEERNGLVAQNKTHNLPVCDLQTELANSASGTGLAFIIFTEAINQFPGAQLWAV 479
            ||.:..|                  ..|:.:|      :|||.||||:.:.:|:.|.|.:.|||:
Zfish   326 GFMSYIT------------------KRPIEEL------AASGPGLAFLAYPQAVTQLPMSSLWAI 366

  Fly   480 LFFLMLFTLGIDSQFGTLEGVVTSLVDMKLFPNL---PKEYIVGALCFSCCTISMCFANGAGSYI 541
            |||.||..||:||||.|:||.:|:|:|.  :|.:   .|:..:..:|.....|........|.|:
Zfish   367 LFFSMLMMLGLDSQFCTVEGFITALMDE--YPTVLRKRKKIFILIVCLVSFIIGFSNITQGGLYV 429

  Fly   542 FQLMDSF-AGNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYWMFCWKYLSPCAMVTI 605
            |:|.|.: |....||.:..||.:||::.||..:|..:||.|.|.||..:|..||.|.:|...:.:
Zfish   430 FKLFDYYSASGMCLLFLVFFETISIAWFYGAEKFYKNIEEMIGYRPCGFWKQCWIYFTPTICLGV 494

  Fly   606 LLASFYQL--LTEGS-SYPAWIGSKGATEGMEWPHWCIVVAFFLILSSILWIP 655
            ...|..::  ||.|. .||||      .:|:.|         .:.|||::.||
Zfish   495 FTFSAIEMTPLTLGKYVYPAW------GQGVGW---------LMSLSSMVLIP 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	220/548 (40%)
slc6a1l	XP_021330952.1	SLC5-6-like_sbd	15..558	CDD:320982	225/562 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810