DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10804 and slc6a7

DIOPT Version :9

Sequence 1:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	XP_005161359.1	Gene:	slc6a7 / 562050	ZFINID:	ZDB-GENE-070112-1492	Length:	652	Species:	Danio rerio

Alignment Length:	568	Identity:	225/568 - (39%)
Similarity:	313/568 - (55%)	Gaps:	66/568 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 RESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIFYLELAIGQRL 182
            |:.|..|..|||:.|||.||||||||||||..:||||.||:||||||...|:|:|.:||::||..
Zfish    71 RDQWGGKYEFLLSCIGYCVGLGNVWRFPYLCYRNGGGVFLIPYFIMLFFTGMPLFLMELSLGQYG 135

  Fly   183 RKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPLPWADCPTRLYKNF 247
            ..|.|.|| :..|.|.||||....||.:|.||||.||||...||..||:|||||: |..  .:|.
Zfish   136 AAGPITVW-KCCPLLKGIGIGMLCVSTLVCLYYNVIIAWTFYYLGSSFQSPLPWS-CDA--LQNI 196

  Fly   248 TYDHEPECVASSPTQFYWYRTTLQCSESVDM--PENFNYHMAIALIVSWFLVYICMVQGITSSGK 310
            ...........||::.:|....|....|..:  |....:.:|:.|:.:|.::::||::||.||||
Zfish   197 ALCANKTNSTQSPSEVFWNEKVLGVVHSTGLSDPGPVRWPLALCLLAAWIIIFLCMLKGIHSSGK 261

  Fly   311 IVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLDPVVWLEAGTQIFFSLGLAFGGL 375
            :||:||.|||.||::...||.||:|:.||||...||:|:.|.|..||.:|.:|||:|||:..|||
Zfish   262 VVYVTATFPYFVLLVLIIRGATLEGSLDGVAFYLTPKWDQLADAQVWNDAASQIFYSLGIGVGGL 326

  Fly   376 IAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIG---FKATATFDRCTEERNGLVAQNK 437
            ::.:|||..:||..||.|::::.||.||.|||..:||::|   ||.....|:..:
Zfish   327 LSMASYNKFDNNVIRDTIIITIGNCSTSFFAGFAIFSILGHMAFKKGVPVDKVAD---------- 381

  Fly   438 THNLPVCDLQTELANSASGTGLAFIIFTEAINQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGVVT 502
                             ||.||||:.:.||:...||:..|::|||||||.||:|:.||.:||:.|
Zfish   382 -----------------SGPGLAFVAYPEALALLPGSVFWSILFFLMLFMLGVDTLFGNMEGICT 429

  Fly   503 SLVDMKLFPNL-----PKEYIVGALCFSCCTISMCFANGAGSYIFQLMDSFAGNFPLLIIALFEC 562
            :::|.  ||.|     .|...:..||||...:.:......|.|.|.|:|||:.:|.|:||.||.|
Zfish   430 AVLDE--FPQLRSNLKHKTLFLAVLCFSFYLMGLLLITDGGIYWFTLIDSFSTSFGLIIITLFMC 492

  Fly   563 LSISYIYGVRRFSDDIEMMTGSRPNF------YWMFCWKYLSPCAMVTILLASFYQL----LTEG 617
            :.||:.|||.:|..||..|....|.:      |:..||...:|..:..||...|.::    |..|
Zfish   493 IGISFFYGVNQFCQDIVDMICRCPPWCTKMLLYFKACWVVFTPFLLTFILTYIFIEMYRTSLRYG 557

  Fly   618 S-SYPAWIGSKGATEGMEWPHWCIVVAFFLILSSILWIPIVAVLRLCG 664
            | .||.|..:.|...|.           ...|..::| .|||:.:..|
Zfish   558 SYVYPIWGKALGVCMGA-----------LCCLQILIW-AIVAISKESG 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	223/561 (40%)
slc6a7	XP_005161359.1	SLC5-6-like_sbd	71..610	CDD:294310	225/568 (40%)
slc6a7	XP_005161359.1	PotE	<235..564	CDD:223605	138/357 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810