DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10804 and slc6a22.2

DIOPT Version :9

Sequence 1:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	XP_005166102.1	Gene:	slc6a22.2 / 561024	ZFINID:	ZDB-GENE-030616-628	Length:	608	Species:	Danio rerio

Alignment Length:	577	Identity:	210/577 - (36%)
Similarity:	301/577 - (52%)	Gaps:	80/577 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 IVEGEKEGEERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIF 172
            :|:...:...||.|.:|:.||||..|:.:|||||||||||..|||||||.|||.:.|...|||:|
Zfish    18 LVKARPKPPAREQWANKLEFLLAVAGHIIGLGNVWRFPYLCYKNGGGAFFVPYVLFLFTCGIPLF 82

  Fly   173 YLELAIGQRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPLPWA 237
            :||.::||...:|.|..|.::.|...|:|..|.||.....:||..|:||..:||..||.|.||||
Zfish    83 FLETSLGQFTSQGGITCWRKICPLFEGLGFGSQVVVLYTGVYYIIILAWAFLYLFSSFTSELPWA 147

  Fly   238 DCPTRLYKNFTYDHEPECV--------------ASSPTQFYWYRTTLQCSESVDMPENFNYHMAI 288
            .|.       .|.:.|.|:              .:||...:|.|..|..|..::...|..:.:|:
Zfish   148 SCN-------NYWNTPSCMEFSESNITEYSPNKTTSPVIEFWERRILGLSGGIEQIGNVRWDLAL 205

  Fly   289 ALIVSWFLVYICMVQGITSSGKIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLD 353
            .|:::|.:.|.|:.:|:.|:||:||.||.|||::||:...||:||.||.:|:.....|....|.|
Zfish   206 CLLLAWIICYFCVWKGVKSTGKVVYFTATFPYLMLIVLLVRGLTLPGAINGITFYLYPDPSRLKD 270

  Fly   354 PVVWLEAGTQIFFSLGLAFGGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFKA 418
            |.||::||:|||:|.|:..|.|.|..|||..:||||||.:.:.|.|..||..||..:|||:||.|
Zfish   271 PQVWMDAGSQIFYSYGVCTGVLTALGSYNKYDNNCYRDCVYLCLLNSLTSFVAGFAIFSVLGFMA 335

  Fly   419 TATFDRCTEERN---GLVAQNKTHNLPVCDLQTELANSASGTGLAFIIFTEAINQFPGAQLWAVL 480
                    :|:.   .|||:                   ||.|||||.:..|:...|..||||:.
Zfish   336 --------DEQGVDISLVAE-------------------SGPGLAFIAYPRAVALMPLPQLWAIF 373

  Fly   481 FFLMLFTLGIDSQFGTLEGVVTSLVDMKLFPNL-----PKEYIVGALCFSCCTISMCFANGAGSY 540
            ||:|:..||:||:|...|.:|||:.||  :|:.     .:::::..:|.:...:.:......|.|
Zfish   374 FFIMIIFLGLDSEFVYQEALVTSISDM--YPSFFQVGHRRKFLLLFICSASFFVGLLMVTEGGLY 436

  Fly   541 IFQLMDSFA-GNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYWMF---CWKYLSP-- 599
            :|||.|.:| ....||..|:.:.:.:.::||..|..|.:|.|.|.||   |.|   |||||:|
Zfish   437 VFQLFDYYACSGMTLLTFAILQSICVGWVYGADRHYDCVEDMIGYRP---WPFMKCCWKYLTPAI 498

  Fly   600 CAMVTILLASFYQLLTEGSSYPAWIGSKGATEGMEWPHWCIVVAFFLILSSILWIPI 656
            |....|.....|..|...:.|             |:|.|...:..|..|||.|.:|:
Zfish   499 CTGTFIFSLVQYTPLKFNNEY-------------EYPWWGYAIGGFFTLSSTLLVPL 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	207/565 (37%)
slc6a22.2	XP_005166102.1	SLC6sbd-TauT-like	28..565	CDD:271387	209/567 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810