DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10804 and slc6a19a.1

DIOPT Version :9

Sequence 1:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001091648.1	Gene:	slc6a19a.1 / 553256	ZFINID:	ZDB-GENE-070620-2	Length:	629	Species:	Danio rerio

Alignment Length:	581	Identity:	248/581 - (42%)
Similarity:	362/581 - (62%)	Gaps:	35/581 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 KEGEERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIFYLELA 177
            :|..||..||:|..::|..:|:.||||||||||||.|.:|||||::|:.|:|.::|:|:.:||.|
Zfish    26 QEAGERPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGVPLLHLEFA 90

  Fly   178 IGQRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPLPWADCPTR 242
            ||||||.|::|||..:||||.|:||:|.:.|:||.:|||||:||.:.||.:|.:.||||:.||..
Zfish    91 IGQRLRSGSVGVWRSISPYLTGVGIASMLASFIVGMYYNTIMAWVMWYLFNSLQEPLPWSQCPVN 155

  Fly   243 LYKNFTYDHEPECVASSPTQFYWYRTTLQCSESVDMPENFNYHMAIALIVSWFLVYICMVQGITS 307
            |.:.....   ||..|||..::|||.||..|.:::......:.:.:.|:.:|..:|||.::||.:
Zfish   156 LNRTGLVS---ECERSSPVDYFWYRETLNTSTAIEDSGALQWWLVLCLLCAWTFLYICCIRGIET 217

  Fly   308 SGKIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLDPVVWLEAGTQIFFSLGLAF 372
            :||.||:|:..|||||.||..|.:||||:.:|:..||||....|::|..||:||.|:.||..|||
Zfish   218 TGKAVYITSTLPYVVLTIFLIRALTLKGSVNGIKFLFTPDVNELMNPSTWLDAGAQVLFSFSLAF 282

  Fly   373 GGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFKATATFDRCTE---------- 427
            ||||:|||||..:|||.:||:.:|:.|..||:::..|::|:|||:||..:|.|.:
Zfish   283 GGLISFSSYNSVHNNCEQDAVTISIINGLTSVYSATVIYSIIGFRATENYDICLDSNILSLLNAF 347

  Fly   428 --------ERNGLVAQNKTH----------NLPVCDLQTELANSASGTGLAFIIFTEAINQFPGA 474
                    |.|..||..:.:          .|..||:||.|:....|||||||:|||||.:.|.:
Zfish   348 DLPEGSITENNYTVALQQLNISRPDIIQELQLKTCDMQTLLSEGVEGTGLAFIVFTEAITKMPVS 412

  Fly   475 QLWAVLFFLMLFTLGIDSQFGTLEGVVTSLVDMKLFP-NLPKEYIVGALCFSCCTISMCFANGAG 538
            .||:||||:|||.||:.:.||.:||||..|.|:.|.| ..|||...|..|......::.|...:|
Zfish   413 PLWSVLFFIMLFCLGLSTMFGNIEGVVVPLQDLNLLPKRWPKEVFTGLTCVVSFLTALVFVQSSG 477

  Fly   539 SYIFQLMDSFAGNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYWMFCWKYLSPCAMV 603
            :|...|.|.|||:.|||:|||.|.:::.|:||:.||::||:.|.|.:||.:|...|::|||..::
Zfish   478 NYWLALFDGFAGSIPLLVIALCELIAVVYVYGIDRFNEDIKFMVGHKPNIFWQISWRFLSPVILL 542

  Fly   604 TILLASFYQLLTEGSSYPAWIGSKG---ATEGMEWPHWCIVVAFFLILSSILWIPIVAVLR 661
            .||:..|...:::..:|..|.....   ..:.:::|:|..||.|.|.....|.||.||:.|
Zfish   543 VILIFYFITTVSKQLTYNVWDPQSADFPTLKEVDYPNWISVVIFVLAGVPSLCIPGVAIGR 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	244/572 (43%)
slc6a19a.1	NP_001091648.1	SLC5-6-like_sbd	31..611	CDD:294310	246/576 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48419
OrthoDB	1	1.010	-	-		D251682at33208
OrthoFinder	1	1.000	-	-		FOG0001784
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101967
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4904
SonicParanoid	1	1.000	-	-		X2259
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860