DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10804 and slc6a1b

DIOPT Version :9

Sequence 1:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001007363.1	Gene:	slc6a1b / 492490	ZFINID:	ZDB-GENE-041114-57	Length:	600	Species:	Danio rerio

Alignment Length:	588	Identity:	232/588 - (39%)
Similarity:	333/588 - (56%)	Gaps:	59/588 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 GSEASTSKAKAELVAIATASADQQDI---VEGEKEGEERESWDSKIMFLLATIGYAVGLGNVWRF 144
            |::||......|:....||:...:.:   |:.:||..:||:|..|..|||:.:|||:||||||||
Zfish     5 GTKASDGHVLTEVNEAPTANDKPKTLVVKVQKKKELPDRETWQGKFDFLLSCVGYAIGLGNVWRF 69

  Fly   145 PYLAQKNGGGAFLVPYFIMLCIQGIPIFYLELAIGQRLRKGAIGVWSQVSPYLGGIGISSAVVSY 209
            |||..||||||||:|||:.|...|:|:|:||.|:||....|.:||| :::|...|:|:::||:|:
Zfish    70 PYLCGKNGGGAFLIPYFLTLIFAGVPLFFLETALGQYTSIGGLGVW-KLAPMFKGVGLAAAVLSF 133

  Fly   210 IVALYYNTIIAWCLIYLLHSFESPLPWADCPT-----RLYKNFTYDHEPECVASSPTQFYWYRTT 269
            .:.:||..||||.:.||.:||.:.|||..|..     :.:.|::..:... :.|:..:| |.|..
Zfish   134 WLNIYYIVIIAWAIYYLYNSFTTDLPWKSCDNPWNTDKCFSNYSMANIGN-MTSAVVEF-WERNM 196

  Fly   270 LQCSESVDMPENFNYHMAIALIVSWFLVYICMVQGITSSGKIVYMTAIFPYVVLIIFFFRGITLK 334
            .|.::.::.|......:||.|.::|.|||.|:.:|:..:||:||.:|.:||.:|.|.|.||:||.
Zfish   197 HQLTDGLEKPGEIRLPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYFMLFILFIRGVTLP 261

  Fly   335 GAADGVAHLFTPRWETLLDPVVWLEAGTQIFFSLGLAFGGLIAFSSYNPANNNCYRDAILVSLTN 399
            ||.:|:....||.:..|.:..|||:|.||||||.||..|.|||..||||.|||.|:|:|:|...|
Zfish   262 GAKEGILFYVTPEFSKLKESEVWLDAATQIFFSYGLGLGSLIALGSYNPFNNNVYKDSIIVCCIN 326

  Fly   400 CGTSMFAGVVVFSVIGFKATATFDRCTEERNGLVAQNKTHNLPVCDLQTELANSASGTGLAFIIF 464
            ..||||||.|:||::||.|..|                  ..|:.|:      :|||.||||:.:
Zfish   327 SFTSMFAGFVIFSIVGFMAHIT------------------KRPIADV------AASGPGLAFLAY 367

  Fly   465 TEAINQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGVVTSLVDMKLFPNL---PKEYIVGALCFSC 526
            .||:.|.|.:.|||||||.||..|||||||.|:||.:|:|||.  ||..   .:|..:..:|...
Zfish   368 PEAVTQLPISPLWAVLFFSMLLMLGIDSQFCTVEGFITALVDE--FPRALRGRREIFIAVVCLVS 430

  Fly   527 CTISMCFANGAGSYIFQLMDSF-AGNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYW 590
            ..|.:......|.|:|:|.|.: |....||.:..|||:|||:.|||.:|..::|.|.|.:|..:|
Zfish   431 YLIGLSNITQGGLYVFKLFDYYSASGMCLLFLVFFECVSISWFYGVNKFYGNLEEMIGYKPCIWW 495

  Fly   591 MFCWKYLSPCAMVTILLASFYQ---LLTEGSSYPAWIGSKGATEGMEWPHWCIVVAFFLILSSIL 652
            ..||...:|..:..:.|.|..|   |......:|.|....|         ||      :.|||::
Zfish   496 KLCWVVFTPLIVAGVFLFSAVQMVPLTLNNYVFPKWGQGVG---------WC------MALSSMV 545

  Fly   653 WIP 655
            .||
Zfish   546 LIP 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	221/548 (40%)
slc6a1b	NP_001007363.1	SLC5-6-like_sbd	2..600	CDD:294310	232/588 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810