DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10804 and SLC6A18

DIOPT Version :9

Sequence 1:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_872438.2	Gene:	SLC6A18 / 348932	HGNCID:	26441	Length:	628	Species:	Homo sapiens

Alignment Length:	581	Identity:	257/581 - (44%)
Similarity:	367/581 - (63%)	Gaps:	38/581 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 GEERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIFYLELAIG 179
            |:||..||:|..:||:..|:||||||:||||||.|..||||||:||.|.|..:|||||::|||||
Human    15 GDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELAIG 79

  Fly   180 QRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPLPWADCPTRLY 244
            ||||||::|||:.:||||.|:|:....:|::::||||||:||.|.|||:||:.||||:.||..|.
Human    80 QRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWSSCPPDLN 144

  Fly   245 KNFTYDHEPECVASSPTQFYWYRTTLQCSESVDMPENFNYHMAIALIVSWFLVYICMVQGITSSG 309
            :....:   ||..||...::|||.||..:..::...:..:.:.|.|..||.:||:|:::||.::|
Human   145 RTGFVE---ECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAVVYMCVIRGIETTG 206

  Fly   310 KIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLDPVVWLEAGTQIFFSLGLAFGG 374
            |::|.||:|||:||.||..||:||.||..|:.:||||....|.:|.|||:|.|||||||.|||||
Human   207 KVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAFGG 271

  Fly   375 LIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFKATATFDRCTEERNGLVAQN--- 436
            .|||:|||...|:|.:||::::|.|..||::|.:.||||:|||||..::.|. :||.|...|
Human   272 HIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATNDYEHCL-DRNILSLINDFD 335

  Fly   437 ------------------------KTHNLPV--CDLQTELANSASGTGLAFIIFTEAINQFPGAQ 475
                                    :...||:  |.|:..|..||||.||||::|||.....|||.
Human   336 FPEQSISRDDYPAVLMHLNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAP 400

  Fly   476 LWAVLFFLMLFTLGIDSQFGTLEGVVTSLVDMKLFPN-LPKEYIVGALCFSCCTISMCFANGAGS 539
            :||:|||.||||||:.:.|||:|.|:|.|:|:.:.|. :|||.:.|.:|..|...:.||...:|:
Human   401 VWAMLFFGMLFTLGLSTMFGTVEAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGN 465

  Fly   540 YIFQLMDSFAGNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYWMFCWKYLSPCAMVT 604
            |..::.|:||.:..||::|..|.:.:.|:||::||.|||..|||.||:.||...|:.:|| .::|
Human   466 YWLEIFDNFAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSP-LLLT 529

  Fly   605 ILLASFYQLLTEGSSYPAWIGSKGATEGME---WPHWCIVVAFFLILSSILWIPIVAVLRL 662
            |.:|....|..:...|.||..........:   :|.|.......|.|..:||:|:.|:.:|
Human   530 IFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQL 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	253/573 (44%)
SLC6A18	NP_872438.2	SLC6sbd_B0AT3	17..591	CDD:212086	256/579 (44%)
SLC6A18	NP_872438.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	602..628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H40785
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48419
OrthoDB	1	1.010	-	-		D251682at33208
OrthoFinder	1	1.000	-	-		FOG0001784
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101967
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4904
SonicParanoid	1	1.000	-	-		X2259
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.860