DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10804 and Slc6a18

DIOPT Version :9

Sequence 1:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_058859.2	Gene:	Slc6a18 / 29323	RGDID:	69352	Length:	615	Species:	Rattus norvegicus

Alignment Length:	584	Identity:	266/584 - (45%)
Similarity:	370/584 - (63%)	Gaps:	45/584 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 EERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIFYLELAIGQ 180
            :||..||:|:.:||:.||:||||||:||||||...:||||||:||||.|..:|||:||:||||||
  Rat    15 DERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCHTHGGGAFLIPYFIALVFEGIPLFYIELAIGQ 79

  Fly   181 RLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPLPWADCPTRLYK 245
            |||:|:||||..:||||||:|:....||::|:||||||:.|.|.:.|:||:.||||:.||..|.:
  Rat    80 RLRRGSIGVWKTISPYLGGVGLGCFSVSFLVSLYYNTILLWVLWFFLNSFQHPLPWSTCPLDLNR 144

  Fly   246 NFTYDHEPECVASSPTQFYWYRTTLQCSESVDMPENFNYHMAIALIVSWFLVYICMVQGITSSGK 310
            .   ....||.:|....::|||.||..:..:.......:.:.:.|:..|..||:|:::||.|:||
  Rat   145 T---GFVQECQSSGTVSYFWYRQTLNITSDISNTGTIQWKLFLCLVACWTTVYLCVIRGIESTGK 206

  Fly   311 IVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLDPVVWLEAGTQIFFSLGLAFGGL 375
            ::|.||:|||:||.||..||:||.||.:|:.:||||..:.|.:|.|||:|.|||||||.|||||.
  Rat   207 VIYFTALFPYLVLTIFLIRGLTLPGATEGLTYLFTPNMKILQNPRVWLDAATQIFFSLSLAFGGH 271

  Fly   376 IAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFKATATFDRCTEERNGLVAQN---- 436
            |||:|||...|||.:||:.::|.|..||::|.:.:||::||||:..:.||. :||.|...|
  Rat   272 IAFASYNQPRNNCEKDAVTIALVNSMTSLYASITIFSIMGFKASNDYGRCL-DRNILSLINEFDF 335

  Fly   437 -----------------------KTHNLPV--CDLQTELANSASGTGLAFIIFTEAINQFPGAQL 476
                                   :...||:  |.|:..|..||||.|||||:||||:...|||.:
  Rat   336 PELSISRDEYPSVLMYLNATQPERVARLPLKTCHLEDFLDKSASGPGLAFIVFTEAVLHMPGASV 400

  Fly   477 WAVLFFLMLFTLGIDSQFGTLEGVVTSLVDMKLFP-NLPKEYIVGALCFSCCTISMCFANGAGSY 540
            |:||||.||||||:.|.||.:|||:|.|.||.:.| .:|||.:.|.:||.|...::||...:|||
  Rat   401 WSVLFFGMLFTLGLSSMFGNMEGVITPLFDMGILPKGVPKETMTGVVCFICFLSAICFTLQSGSY 465

  Fly   541 IFQLMDSFAGNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYWMFCWKYLSPCAMVTI 605
            ..::.||||.:..|:|.|..|.:.:.::||::||.||||.|||.||:.||...|:.:||..:..|
  Rat   466 WLEIFDSFAASLNLIIFAFMEVVGVIHVYGIKRFCDDIEWMTGRRPSLYWQVTWRVVSPMLLFGI 530

  Fly   606 LLASFYQLLTEGS-SYPAW------IGSKGATEGMEWPHWCIVVAFFLILSSILWIPIVAVLRL 662
            .| |:..||.:.| ||.||      ..|:   |...:|.|..|....|.....||:|.:|:.:|
  Rat   531 FL-SYIVLLAQSSPSYKAWNPQYEHFPSR---EEKLYPGWVQVTCVLLSFLPSLWVPGIALAQL 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	263/577 (46%)
Slc6a18	NP_058859.2	SLC6sbd_B0AT3	16..591	CDD:212086	266/583 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H40785
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48419
OrthoDB	1	1.010	-	-		D251682at33208
OrthoFinder	1	1.000	-	-		FOG0001784
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101967
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2259
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.830