DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10804 and SLC6A16

DIOPT Version :9

Sequence 1:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	XP_011525161.2	Gene:	SLC6A16 / 28968	HGNCID:	13622	Length:	781	Species:	Homo sapiens

Alignment Length:	702	Identity:	190/702 - (27%)
Similarity:	327/702 - (46%)	Gaps:	120/702 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 SDAFDESSELEQDPPPFGSEASTSKAK-AE-------------LVAIATASADQQDIVEGEKEGE 116
            |..:::...|.:....:.|||..|.|: ||             |.|:..::.:|:...|..:..|
Human   111 SQTWEDKGSLTRSATSWTSEAQVSAARVAEAQARTSQPKQISVLEALTASALNQKPTHEKVQMTE 175

  Fly   117 ERES--------WDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIFY 173
            ::||        |.||..::||.:|:::....:|||.||...:||.:|...|..||.:.|:|:.:
Human   176 KKESEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLF 240

  Fly   174 LELAIGQRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPLPWAD 238
            ||:|.||.:|:|.:|||..::|::||:|.||.:|.:|:.||:|.:.:|.:.|:..||:.|:||..
Human   241 LEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWEK 305

  Fly   239 CPTRLYKNFTYDHEPECVASSPTQFYWYRTTLQCSESVDMPENFNYHMAIALIVSWFLVYICMVQ 303
            ||..:..:   ..:|||..::|:.::||:..|:.|:.::...:..|.:.:...:.|.||...|:.
Human   306 CPLTMNSS---GFDPECERTTPSIYFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMIN 367

  Fly   304 GITSSGKI--VYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLDPVVWLEAGTQIFF 366
            |:.|:|||  ||..:                                       ||..||.|:..
Human   368 GLKSTGKISDVYNMS---------------------------------------VWSLAGGQVLS 393

  Fly   367 SLGLAFGGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFKATATFDRCTEERNG 431
            :.|:..|.:.:.:||.|.:|||..||.|||:.|..|.:......|.|:||.||....||.|....
Human   394 NTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATVITHRCCERNAE 458

  Fly   432 LVAQ---------------NKTHN-----------LP------------VCDLQTELANSASGTG 458
            ::.:               |..:|           ||            .|:::|:...::.|..
Human   459 ILLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREVTECNIETQFLKASEGPK 523

  Fly   459 LAFIIFTEAINQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGVVTSLVD-MKLFPNLPKEYIVGA- 521
            .||:.|.||::..|.:..|:.:|||||..:|:.|..|.::|::|.|.| ...|....|..|||.
Human   524 FAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFSFFRKHTKLLIVGVF 588

  Fly   522 -LCFSCCTISMCFANGAGSYIFQLMDSFAGNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGS- 584
             |.|.|   .:.|...:|||..:|:..:...||::::.:||.:::|:.||.|||..|:.::.|.
Human   589 LLMFVC---GLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGARRFLADLTILLGHP 650

  Fly   585 -RPNFYWMFCWKYLSPCAMVTILLASFYQLLTEGSSYPAWIGSKGATEGMEWPHWCIVVAFFLIL 648
             .|.|.|:  |.:|.|..::.|.:.....|..:..:|.:|..|........:|.|.:::  .:.|
Human   651 ISPIFGWL--WPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEVLRPYPPWALLL--MITL 711

  Fly   649 SSILWIPIVAVLRLCGIKVV----EDSDPAWFPEAELREVHGIVPHEPTELE 696
            .:|:.:||.|....|.|..:    :..|........|...|.:.|.:..:.|
Human   712 FAIVILPIPAYFVYCRIHRIPFRPKSGDGPMTASTSLPLSHQLTPSKEVQKE 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	168/593 (28%)
SLC6A16	XP_011525161.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910