Protein Alignment CG10804 and Slc6a4

DIOPT Version :10

• Sequence 1: NP_001138150.1
• Gene: CG10804 / 31317
• FlyBaseID: FBgn0029663
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_037166.2
• Gene: Slc6a4 / 25553
• RGDID: 3714
• Length: 630
• Species: Rattus norvegicus
• Alignment Length: 669
• Identity: 237/669 - (35%)
• Similarity: 364/669 - (54%)
• Gaps: 90/669 - (13%)

  Fly    61 NQGFMSDAFD-----ESSELEQDPPPFGSEASTSKAKAELVAIATASADQQ----------DIVE 110
            :|..:|:..|     |:..|::..|.....|..|:......|:.:.||..:          .:|.
  Rat     8 SQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVA 72

  Fly   111 GEKEGEERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIFYLE 175
            ..::| |||:|..|:.|||:.|||||.|||:|||||:..:|||||||:||.||....|||:||:|
  Rat    73 EIRQG-ERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYME 136

  Fly   176 LAIGQRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPLPWADCP 240
            ||:||..|.|.|.:|.::.|...|||.:..::::.:|.||||||||.|.||:.|....|||..|.
  Rat   137 LALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCT 201

  Fly   241 --------TRLY--KNFTYD-HEPECVASSPTQFYWYRTTLQCSESVDMPE--NFNYHMAIALIV 292
                    |..:  .|.|:. |     ::||.:.::.|..||..:|..:.:  ..::.:.:.:::
  Rat   202 NSWNTGNCTNYFAQDNITWTLH-----STSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVL 261

  Fly   293 SWFLVYICMVQGITSSGKIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLDPVVW 357
            .:.::|..:.:|:.:|||:|::||.|||:||.:...||.||.||..||.....|.|:.||:..||
  Rat   262 IFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVW 326

  Fly   358 LEAGTQIFFSLGLAFGGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFKATATF 422
            ::|..|||||||..||.|:||:|||..|||||:||::.|:.||.||..:|.|:|:|:|:.|
  Rat   327 VDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMA---- 387

  Fly   423 DRCTEERNGLVAQNKTHNLPVCDLQTELANSASGTGLAFIIFTEAINQFPGAQLWAVLFFLMLFT 487
                |.||..|              :|:|..| |..|.||.:.|||...|.:..:|::|||||.|
  Rat   388 ----EMRNEDV--------------SEVAKDA-GPSLLFITYAEAIANMPASTFFAIIFFLMLIT 433

  Fly   488 LGIDSQFGTLEGVVTSLVDMKLFPNL---PKEYIVGALCFSCCTISMCFANGAGSYIFQLMDSFA 549
            ||:||.|..||||:|:::|.  ||::   .:|:.|..:..:|...|:......|:|:..|::.:|
  Rat   434 LGLDSTFAGLEGVITAVLDE--FPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYA 496

  Fly   550 GNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYWMFCWKYLSPCAMVTIL---LASFY 611
            ....:|.:||.|.:::|:.||:.:|..|::.|.|..|.::|..||..:||..::.|:   |.|..
  Rat   497 TGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPP 561

  Fly   612 QLLTEGSSYPAWIGSKGATEGMEWPHWCIVVAFFLILSSILWIPIVAVLRLCGIKVVEDSDPAWF 676
            ||.....:|               |||.||:.:.:.:||::.||...:.||.       |.|...
  Rat   562 QLRLFQYNY---------------PHWSIVLGYCIGMSSVICIPTYIIYRLI-------STPGTL 604

  Fly   677 PEAELREVHGIVPHEPTEL 695
            .|   |.:..|.|..|||:
  Rat   605 KE---RIIKSITPETPTEI 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	210/559 (38%)
Slc6a4	NP_037166.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..60		8/36 (22%)
		5HT_transport_N	24..64	CDD:397524	7/39 (18%)
		SLC6sbd_SERT	79..615	CDD:271399	219/590 (37%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624		3/5 (60%)