Protein Alignment CG10804 and Slc6a3

DIOPT Version :9

• Sequence 1: NP_001138150.1
• Gene: CG10804 / 31317
• FlyBaseID: FBgn0029663
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_036826.1
• Gene: Slc6a3 / 24898
• RGDID: 3715
• Length: 619
• Species: Rattus norvegicus
• Alignment Length: 602
• Identity: 231/602 - (38%)
• Similarity: 329/602 - (54%)
• Gaps: 75/602 - (12%)

  Fly   114 EGEERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIFYLELAI 178
            |.:|||:|..||.|||:.||:||.|.||||||||..|||||||||||.:.:.|.|:|:||:|||:
  Rat    56 EAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL 120

  Fly   179 GQRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPLPWADCPTRL 243
            ||..|:||.||| ::.|.|.|:|.:..::|:.|..:||.||||.|.|...||...|||..|
  Rat   121 GQFNREGAAGVW-KICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC---- 180

  Fly   244 YKNFTYDHEPEC-----------------VASSPTQFYWYRTTLQCSES--VDMPENFNYHMAIA 289
              |.|: :.|.|                 ..::|...|:.|..|...:|  :|......:.:...
  Rat   181 --NNTW-NSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTAC 242

  Fly   290 LIVSWFLVYICMVQGITSSGKIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLDP 354
            |::...|:|..:.:|:.:|||:|::||..|||||.....||:||.||.||:....:..:..|.:.
  Rat   243 LVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEA 307

  Fly   355 VVWLEAGTQIFFSLGLAFGGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFKAT 419
            .||::|.||:.||||:.||.||||||||...||||||||:.:..|..||..:|.||||.:|:.|
  Rat   308 SVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMA- 371

  Fly   420 ATFDRCTEERNGLVAQNKTHNLPVCDLQTELANSASGTGLAFIIFTEAINQFPGAQLWAVLFFLM 484
                             :.||:|:.|:.|:      |.||.|||:.|||...|.:..||.:||||
  Rat   372 -----------------QKHNVPIRDVATD------GPGLIFIIYPEAIATLPLSSAWAAVFFLM 413

  Fly   485 LFTLGIDSQFGTLEGVVTSLVD-MKLFPNLPKEYIVGALCFSCCTISMCFANGAGSYIFQLMDSF 548
            |.||||||..|.:|.|:|.||| .:|.....:.:.:|.:..:......|..|| |.|:|.|:|.|
  Rat   414 LLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNG-GIYVFTLLDHF 477

  Fly   549 AGNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYWMFCWKYLSPCAMVTILLASFYQL 613
            |....:|...|.|.:.:::.|||::|||||:.|||.|||.||..|||.:|||.::.:::.|.  :
  Rat   478 AAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSI--V 540

  Fly   614 LTEGSSYPAWIGSKGATEGMEWPHWCIVVAFFLILSSILWIPIVAVLRLCGIKVVEDSDPAWFPE 678
            ......|.|:|          :|.|...:.:.:..||:..:||.|..:.|.:       |..|.|
  Rat   541 TFRPPHYGAYI----------FPDWANALGWIIATSSMAMVPIYATYKFCSL-------PGSFRE 588

  Fly   679 AELREVHGIVPHEPTEL 695
               :..:.|.|.:..:|
  Rat   589 ---KLAYAITPEKDHQL 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	220/560 (39%)
Slc6a3	NP_036826.1	SLC6sbd_DAT1	60..613	CDD:212083	229/598 (38%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		9/38 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810