DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10804 and Slc6a18

DIOPT Version :9

Sequence 1:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001035782.1	Gene:	Slc6a18 / 22598	MGIID:	1336892	Length:	615	Species:	Mus musculus

Alignment Length:	583	Identity:	267/583 - (45%)
Similarity:	371/583 - (63%)	Gaps:	43/583 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 EERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIFYLELAIGQ 180
            :||..||:|:.:||:.||:||||||:||||||.|.:||||||:||||.|..:|||:||:||||||
Mouse    15 DERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCQTHGGGAFLIPYFIALVFEGIPLFYIELAIGQ 79

  Fly   181 RLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPLPWADCPTRLYK 245
            |||:|:||||..:||||||:|:....||::|:|||||::.|.|.:.|:||:.||||:.||..|.:
Mouse    80 RLRRGSIGVWKTISPYLGGVGLGCFSVSFLVSLYYNTVLLWVLWFFLNSFQHPLPWSTCPLDLNR 144

  Fly   246 NFTYDHEPECVASSPTQFYWYRTTLQCSESVDMPENFNYHMAIALIVSWFLVYICMVQGITSSGK 310
            .   ....||.:|....::|||.||..:..:.......:.:.:.|:..|..||:|:::||.|:||
Mouse   145 T---GFVQECQSSGTVSYFWYRQTLNITSDISNTGTIQWKLFLCLVACWSTVYLCVIRGIESTGK 206

  Fly   311 IVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLDPVVWLEAGTQIFFSLGLAFGGL 375
            ::|.||:|||:||.||..||:||.||.:|:.:||||..:||.:|.|||:|.|||||||.|||||.
Mouse   207 VIYFTALFPYLVLTIFLIRGLTLPGATEGLIYLFTPNMKTLQNPRVWLDAATQIFFSLSLAFGGH 271

  Fly   376 IAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFKATATFDRCTEERNGLVAQN---- 436
            |||:||||..|||.:||::::|.|..||::|.:.:|||:||||:..:.||. :||.|...|
Mouse   272 IAFASYNPPRNNCEKDAVIIALVNSMTSLYASIAIFSVMGFKASNDYGRCL-DRNILSLINEFDL 335

  Fly   437 -----------------------KTHNLPV--CDLQTELANSASGTGLAFIIFTEAINQFPGAQL 476
                                   :...||:  |.|:..|..||||.|||||:||||:...|||.:
Mouse   336 PELSISRDEYPSVLMYLNATQTARVAQLPLKTCHLEDFLDKSASGPGLAFIVFTEAVLHMPGASV 400

  Fly   477 WAVLFFLMLFTLGIDSQFGTLEGVVTSLVDMKLFP-NLPKEYIVGALCFSCCTISMCFANGAGSY 540
            |:||||.||||||:.|.||.:|||:|.|:||.:.| .:|||.:.|.:||:|...::||...:|.|
Mouse   401 WSVLFFGMLFTLGLSSMFGNMEGVITPLLDMGILPKGIPKEVMTGVICFACFLSAICFTLQSGGY 465

  Fly   541 IFQLMDSFAGNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYWMFCWKYLSPCAMVTI 605
            ..::.||||.:..|:|.|..|.:.:.:|||::||.||||.|||.||..||...|:.:||..:..|
Mouse   466 WLEIFDSFAASLNLIIFAFMEVVGVIHIYGMKRFCDDIEWMTGRRPGLYWQVTWRVVSPMLLFGI 530

  Fly   606 LLASFYQLLTEGSSYPAW------IGSKGATEGMEWPHWCIVVAFFLILSSILWIPIVAVLRL 662
            .|:....|:....||.||      ..|:   |...:|.|..|....|.....||:|.||:.:|
Mouse   531 FLSYIVLLIQTPPSYKAWNPQYEHFPSR---EEKFYPGWVQVTCVLLSFLPSLWVPGVALAQL 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	264/576 (46%)
Slc6a18	NP_001035782.1	SLC6sbd_B0AT3	16..591	CDD:212086	267/582 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H40785
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48419
OrthoDB	1	1.010	-	-		D251682at33208
OrthoFinder	1	1.000	-	-		FOG0001784
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101967
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4904
SonicParanoid	1	1.000	-	-		X2259
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.860