DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10804 and Slc6a6

DIOPT Version :9

Sequence 1:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	XP_030111163.1	Gene:	Slc6a6 / 21366	MGIID:	98488	Length:	631	Species:	Mus musculus

Alignment Length:	618	Identity:	223/618 - (36%)
Similarity:	322/618 - (52%)	Gaps:	86/618 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 EGEKEGE--ERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIF 172
            |.|.:|:  :||.|.|||.|:|:..|..||||||||||||..||||||||:||||.|...|:|:|
Mouse    41 EDEADGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVF 105

  Fly   173 YLELAIGQRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPLPWA 237
            :||:.|||...:|.|..|.::.|...|||.:|.|:..::.:||..|:||...||.|||:..||||
Mouse   106 FLEVIIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLFHSFQKDLPWA 170

  Fly   238 DCPTRLYKNFTYDHEPECVA------------------SSPTQFYWYRTTLQCSESVDMPENFNY 284
            .|      |.:: :.|:|:.                  :||...:|.|..|..|..:|.|.:..:
Mouse   171 HC------NHSW-NTPQCMEDTLRRNESHWVSLSTANFTSPVIEFWERNVLSLSSGIDNPGSLKW 228

  Fly   285 HMAIALIVSWFLVYICMVQGITSSGKIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWE 349
            .:|:.|::.|.:.:.|:.:|:.|:||:||.||.||:.:|::...||:||.||.:|:.....|...
Mouse   229 DLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGEGIKFYLYPDIS 293

  Fly   350 TLLDPVVWLEAGTQIFFSLGLAFGGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVI 414
            .|.||.||::||||||||..:..|.:.:..|||....|.|||.:|:...|.|||..:|..:||::
Mouse   294 RLGDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSIL 358

  Fly   415 GFKATATFDRCTEERNGLVAQNKTHNLPVCDLQTELANSASGTGLAFIIFTEAINQFPGAQLWAV 479
            ||.|                  :...:.:.|:      :.||.|||||.:.:|:...|....|::
Mouse   359 GFMA------------------QEQGVDIADV------AESGPGLAFIAYPKAVTMMPLPTFWSI 399

  Fly   480 LFFLMLFTLGIDSQFGTLEGVVTSLVDMKLFPNL-----PKEYIVGALCFSCCTISMCFANGAGS 539
            |||:||..||:||||..:||.:|||||  |:|:.     .:|..:..||.....:.:......|.
Mouse   400 LFFIMLLLLGLDSQFVEVEGQITSLVD--LYPSFLRKGYRREIFIAILCSISYLLGLTMVTEGGM 462

  Fly   540 YIFQLMDSFAGN-FPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYWMFCWKYLSPCAMV 603
            |:|||.|.:|.: ..||.:|.|||..|::|||.....|.||.|.|.||..:..:.|..::|...|
Mouse   463 YVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPALCV 527

  Fly   604 TILLASF--YQLLTEGSSYPAWIGSKGATEGMEWPHWCIVVAFFLILSSILWIPIVAVLRLCGIK 666
            ...:.|.  |..||....|             .:|.|.|.:.:.|.|||:|.||:|.|:.||
Mouse   528 GCFVFSLVKYVPLTYNKVY-------------RYPDWAIGLGWGLALSSMLCIPLVIVILLC--- 576

  Fly   667 VVEDSDPAWFPEAELREVHGIVPHEPTE--LER 697
              ....|     ..:|..:.|.|.||..  :||
Mouse   577 --RTEGP-----LRVRIKYLITPREPNRWAVER 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	208/566 (37%)
Slc6a6	XP_030111163.1	SLC5-6-like_sbd	51..592	CDD:382020	215/596 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900