DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10804 and Slc6a5

DIOPT Version :9

Sequence 1:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_976079.1	Gene:	Slc6a5 / 171148	RGDID:	621824	Length:	799	Species:	Rattus norvegicus

Alignment Length:	707	Identity:	260/707 - (36%)
Similarity:	374/707 - (52%)	Gaps:	132/707 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LRG----RLVSKEHGVSHHHHTSLHHQPLYGATNQGFMSDAFDESSELEQDPPPFGSEASTSKAK 92
            |||    ..||...|...|::|     |..|..|             :.|.....|::...|...
  Rat   127 LRGPEEDENVSVAKGTLEHNNT-----PPVGWVN-------------MSQSTVVLGTDGIASVLP 173

  Fly    93 AELVAIATASADQQDIVEGEKEGEERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFL 157
            .. ||..|...|:|    |: |.:.|.:|.||:.|:|:.:||||||||||||||||.:|||||||
  Rat   174 GS-VATTTIPEDEQ----GD-ENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFL 232

  Fly   158 VPYFIMLCIQGIPIFYLELAIGQRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWC 222
            :||.:||.:.|:|||:||:::||...:|.:.||..: |.|.|.||:..::|.::|:|||.||.:.
  Rat   233 IPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYT 296

  Fly   223 LIYLLHSFESPLPWADC----------------------------------------PTRLYKNF 247
            |.||..||.|.|||..|                                        |.....||
  Rat   297 LFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNLTMVNF 361

  Fly   248 TYDHEPECVASSPTQFYWYRTTLQCSESVDMPENFNYHMAIALIVSWFLVYICMVQGITSSGKIV 312
            |.......|:.|...|.::  .|:.|..::.|....:.:...|.::|.:||..:.:||.:|||:|
  Rat   362 TSQANKTFVSGSEEYFKYF--VLKISAGIEYPGEIRWPLPFCLFLAWVIVYASLAKGIKTSGKVV 424

  Fly   313 YMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLDPVVWLEAGTQIFFSLGLAFGGLIA 377
            |.||.||||||:|...||:||.||..|:.:..||:||.|.|..||.:|.|||||||..|:||||.
  Rat   425 YFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLIT 489

  Fly   378 FSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFKATATFDRCTEERNGLVAQNKTHNLP 442
            .||||..:||||||.::|:.||..||:|||.|:||||||.|.               :.|.:...
  Rat   490 LSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAN---------------ERKVNIEN 539

  Fly   443 VCDLQTELANSASGTGLAFIIFTEAINQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGVVTSLVDM 507
            |.|         .|.|:||:::.||:.:.|.:..||::|||||.|||:|:.|.|:|.:|||:.|.
  Rat   540 VAD---------QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDE 595

  Fly   508 KLFPNLPKEYIVGALCFSCCTISMCF-------ANGAGSYIFQLMDSFAGNFPLLIIALFECLSI 565
              ||...:.: .......||   :||       ....|.|:|||:|::|.::.|:|||:||.:.|
  Rat   596 --FPKYLRTH-KPVFTLGCC---ICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGI 654

  Fly   566 SYIYGVRRFSDDIEMMTGSRPNFYWMFCWKYLSPCAMVTILLASFYQL--LTEGSSYPAWIGSKG 628
            ||:||::||.:|||||.|.:||.:|..||.:::|..:..||..||||.  :|.||
  Rat   655 SYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGS---------- 709

  Fly   629 ATEGMEWPHWCIVVAFFLILSSILWIPIVAVLRLC--------GIKVVEDSDPAWFP 677
                ..:|:|.:|:.:.::..|::||||:.|:::.        .:|:|....|.|.|
  Rat   710 ----YRYPNWSMVLGWLMLACSVIWIPIMFVIKMYLAPGRFIERLKLVCSPQPDWGP 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	233/589 (40%)
Slc6a5	NP_976079.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
Slc6a5	NP_976079.1	SLC6sbd_GlyT2	193..789	CDD:271389	239/617 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810