Protein Alignment CG10804 and Slc6a4

DIOPT Version :9

• Sequence 1: NP_001138150.1
• Gene: CG10804 / 31317
• FlyBaseID: FBgn0029663
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_034614.2
• Gene: Slc6a4 / 15567
• MGIID: 96285
• Length: 630
• Species: Mus musculus
• Alignment Length: 634
• Identity: 237/634 - (37%)
• Similarity: 352/634 - (55%)
• Gaps: 90/634 - (14%)

  Fly    83 GSEA--STSKAKAELVAIATASADQQDIVEGEKEGEERESWDSKIMFLLATIGYAVGLGNVWRFP 145
            |.||  ||..|...|||         :|.:|     |||:|..|:.|||:.|||||.|||:||||
Mouse    56 GDEAPHSTPAATTTLVA---------EIHQG-----ERETWGKKMDFLLSVIGYAVDLGNIWRFP 106

  Fly   146 YLAQKNGGGAFLVPYFIMLCIQGIPIFYLELAIGQRLRKGAIGVWSQVSPYLGGIGISSAVVSYI 210
            |:..:|||||||:||.||....|||:||:|||:||..|.|.|.:|.::.|...|||.:..::::.
Mouse   107 YICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWKKICPIFKGIGYAICIIAFY 171

  Fly   211 VALYYNTIIAWCLIYLLHSFESPLPWADCPTRLYKN----------FTYDHEPECV-ASSPTQFY 264
            :|.||||||||.|.||:.||...|||..|     ||          |..|:....: ::||.:.:
Mouse   172 IASYYNTIIAWALYYLISSFTDQLPWTSC-----KNSWNTGNCTNYFAQDNITWTLHSTSPAEEF 231

  Fly   265 WYRTTLQCSESVDMPE--NFNYHMAIALIVSWFLVYICMVQGITSSGKIVYMTAIFPYVVLIIFF 327
            :.|..||..:|..:.:  ..::.:|:.:::.:.::|..:.:|:.:|||:|::||.|||:||.:..
Mouse   232 YLRHVLQIHQSKGLQDLGTISWQLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYIVLSVLL 296

  Fly   328 FRGITLKGAADGVAHLFTPRWETLLDPVVWLEAGTQIFFSLGLAFGGLIAFSSYNPANNNCYRDA 392
            .||.||.||..||.....|.|:.||:..||::|..|||||||..||.|:||:|||..|||||:||
Mouse   297 VRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDA 361

  Fly   393 ILVSLTNCGTSMFAGVVVFSVIGFKATATFDRCTEERNGLVAQNKTHNLPVCDLQTELANSASGT 457
            ::.|:.||.||..:|.|:|:|:|:.|        |.||..|              :|:|..| |.
Mouse   362 LVTSVVNCMTSFVSGFVIFTVLGYMA--------EMRNEDV--------------SEVAKDA-GP 403

  Fly   458 GLAFIIFTEAINQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGVVTSLVDMKLFPNL---PKEYIV 519
            .|.||.:.|||...|.:..:|::|||||.|||:||.|..||||:|:::|.  ||::   .:|:.|
Mouse   404 SLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDE--FPHIWAKRREWFV 466

  Fly   520 GALCFSCCTISMCFANGAGSYIFQLMDSFAGNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGS 584
            ..:..:|...|:......|:|:..|::.:|....:|.:||.|.:.:|:.||:.:|..|::.|.|.
Mouse   467 LIVVITCILGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVVVSWFYGITQFCSDVKEMLGF 531

  Fly   585 RPNFYWMFCWKYLSPCAMVTIL---LASFYQLLTEGSSYPAWIGSKGATEGMEWPHWCIVVAFFL 646
            .|.::|..||..:||..::.|:   |.|..||.....:|               |||.|::.:.:
Mouse   532 SPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNY---------------PHWSIILGYCI 581

  Fly   647 ILSSILWIPIVAVLRLCGIKVVEDSDPAWFPEAELREVHGIVPHEPTEL 695
            ..||::.|||..:.||.       |.|....|   |.:..|.|..|||:
Mouse   582 GTSSVICIPIYIIYRLI-------STPGTLKE---RIIKSITPETPTEI 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	212/559 (38%)
Slc6a4	NP_034614.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		3/6 (50%)
		5HT_transport_N	24..64	CDD:281488	4/7 (57%)
		SLC6sbd_SERT	79..615	CDD:271399	221/590 (37%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624		3/5 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810