DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10804 and Slc6a9

DIOPT Version :9

Sequence 1:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001342104.1	Gene:	Slc6a9 / 14664	MGIID:	95760	Length:	652	Species:	Mus musculus

Alignment Length:	608	Identity:	223/608 - (36%)
Similarity:	339/608 - (55%)	Gaps:	92/608 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 IATASADQQDIVEGEKEGEE----RESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLV 158
            :||.|.:|...|..|...::    |.:|.::|.|:|.::|||||||||||||||..:||||||:.
Mouse    22 VATPSPEQNGAVPSEATKKDQNLTRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMF 86

  Fly   159 PYFIMLCIQGIPIFYLELAIGQRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCL 223
            ||||||...|||:|::||:.||...:|.:||| ::||...|:|....|||..:.:|||.:|....
Mouse    87 PYFIMLIFCGIPLFFMELSFGQFASQGCLGVW-RISPMFKGVGYGMMVVSTYIGIYYNVVICIAF 150

  Fly   224 IYLLHSFESPLPWADC-----------------------PTRLYKNFTYDHEPECVASSPTQFYW 265
            .|...|....||||.|                       |..|..|.::........:||::.||
Mouse   151 YYFFSSMTHVLPWAYCNNPWNTPDCAGVLDASNLTNGSRPAALSGNLSHLFNYTLQRTSPSEEYW 215

  Fly   266 YRTTLQCSESVDMPENFNYHMAIALI----VSWFLVYICMVQGITSSGKIVYMTAIFPYVVLIIF 326
            ....|:.|:.:.   ||. .:.:.|:    |||.:|::|:::|:.||||:||.||.||||||.|.
Mouse   216 RLYVLKLSDDIG---NFG-EVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTIL 276

  Fly   327 FFRGITLKGAADGVAHLFTPRWETLLDPVVWLEAGTQIFFSLGLAFGGLIAFSSYNPANNNCYRD 391
            |.||:||:||..|:.:..||:|:.:|:..||.:|.:|||:|||.|:||||..:|||..:||||||
Mouse   277 FVRGVTLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRD 341

  Fly   392 AILVSLTNCGTSMFAGVVVFSVIGFKATATFDRCTEERNGLVAQNKTHNLPVCDLQTELANSAS- 455
            ::::|:|||.||::||.|:||::||.|.                         .|..:::..|.
Mouse   342 SVIISITNCATSVYAGFVIFSILGFMAN-------------------------HLGVDVSRVADH 381

  Fly   456 GTGLAFIIFTEAINQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGVVTSLVD--------MKLFPN 512
            |.||||:.:.||:...|.:.||::|||.||..||:.:||..||.:||::||        .|
Mouse   382 GPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQK---- 442

  Fly   513 LPKEYIVGALCFSCCTISMCFANGAGSYIFQLMDSFAGNFPLLIIALFECLSISYIYGVRRFSDD 577
              |.|:...:..:...:.:...:.||.|...|||::|.:|.|::|:...|:||.||||.|.:..|
Mouse   443 --KTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIMYIYGHRNYFQD 505

  Fly   578 IEMMTGSRPNFYWMFCWKYLSPCAMVTILLASF--YQLLTEGSSYPAWIGSKGATEGMEWPHWCI 640
            |:||.|..|..::..||:::||..:..||:.:.  |:.:|...              .::|.|.:
Mouse   506 IQMMLGFPPPLFFQICWRFVSPAIIFFILIFTVIQYRPITYNH--------------YQYPGWAV 556

  Fly   641 VVAFFLILSSILWIPIVAVLRLC 663
            .:.|.:.|||::.||:.|:.:||
Mouse   557 AIGFLMALSSVICIPLYALFQLC 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	214/578 (37%)
Slc6a9	NP_001342104.1	SLC6sbd_GlyT1	30..613	CDD:212067	219/600 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810