DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10804 and Slc6a7

DIOPT Version :9

Sequence 1:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_446448.2	Gene:	Slc6a7 / 117100	RGDID:	620928	Length:	637	Species:	Rattus norvegicus

Alignment Length:	646	Identity:	233/646 - (36%)
Similarity:	353/646 - (54%)	Gaps:	88/646 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 ADQQDIVEGEKEGEERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQ 167
            :||.|:........:|.:|..|:.|||:.|||.|||||||||||.|..|||||||||||:||.|.
  Rat    22 SDQGDVDLDVDFAADRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAIC 86

  Fly   168 GIPIFYLELAIGQRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFES 232
            |||:|:|||::||....|.:.|| ::||...|.|.:..::..:||:|||.|||:.|.||..|..|
  Rat    87 GIPLFFLELSLGQFSSLGPLAVW-KISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTS 150

  Fly   233 PLPWADCPTRLYKNFTYDHE---------PECVAS--SPTQFYWYRTTL--QCSESVDMPENFNY 284
            .|||..|..........:|.         |..::|  ||::.||.|..|  |.|:.:..|....:
  Rat   151 NLPWEHCGNWWNTERCLEHRGPKDGNGALPLNLSSTVSPSEEYWSRYVLHIQGSQGIGRPGEIRW 215

  Fly   285 HMAIALIVSWFLVYICMVQGITSSGKIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWE 349
            ::.:.|:::|.:|::|:::|:.||||:||.||.|||::|::...||:||.||..|:....||::.
  Rat   216 NLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFH 280

  Fly   350 TLLDPVVWLEAGTQIFFSLGLAFGGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVI 414
            .||...||:||..|||:|||:.||||:.|:|||..:.|.|||..:|:|.|..||:.||..:|||:
  Rat   281 HLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVL 345

  Fly   415 GFKATATFDRCTEERNGLVAQNKTHNLPVCDLQTELANSASGTGLAFIIFTEAINQFPGAQLWAV 479
            |:                  .::...:||..:      :.:|.||||:::.:|:...|.:..|:.
  Rat   346 GY------------------MSQELGVPVDQV------AKAGPGLAFVVYPQAMTMLPLSPFWSF 386

  Fly   480 LFFLMLFTLGIDSQFGTLEGVVTSLVDMKLFPNLPKEYIV-GALCFSCCTISMCFANGAGSYIFQ 543
            |||.||.|||:||||..||.:||::.|...:...||:.:. |.:|.:...:.:......|.|...
  Rat   387 LFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLV 451

  Fly   544 LMDSFAGNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYWMFCWKYLSPCAMVTILLA 608
            |:|.::.:|.|:::.:..||:::.:||::||..||.||.|.:|..|:..||.:|||..::.:|:.
  Rat   452 LLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALLVY 516

  Fly   609 SF--YQLLTEGSSYPAWIGSKGATEGMEWPHWCIVVAFFLILSSILWIP---IVAVLRLCGI--- 665
            |.  ||        |:..||      ..:|.|..::...:.|.|.|.||   :|||||..|.
  Rat   517 SIVKYQ--------PSEYGS------YRFPAWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWE 567

  Fly   666 KVVEDSDPA--WFPEAE-----------------------LREVHGIVPHEPT--ELERSI 699
            ::.:.|.||  |.|..|                       :|:..||...|.|  |::|.|
  Rat   568 RLQQASRPAIDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKYGGITSFENTAIEVDREI 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	212/559 (38%)
Slc6a7	NP_446448.2	SLC5-6-like_sbd	37..581	CDD:382020	220/582 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810