DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10804 and Slc6a20

DIOPT Version :9

Sequence 1:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_579830.1	Gene:	Slc6a20 / 113918	RGDID:	621651	Length:	616	Species:	Rattus norvegicus

Alignment Length:	594	Identity:	252/594 - (42%)
Similarity:	360/594 - (60%)	Gaps:	51/594 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 GEKEGEE----------RESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLC 165
            |::.|.:          |..|.:.:.|:.|.|.||||||||||||||.|..|||:|||||.|||.
  Rat    12 GQRPGPDEKRARDMEKARPQWGNPLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYLIMLI 76

  Fly   166 IQGIPIFYLELAIGQRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSF 230
            ::|:|:.|||||:|||:|:|:||.|..:||||.|:|::|.|||:.:::|||.|.||...||.|||
  Rat    77 VEGMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWGFWYLFHSF 141

  Fly   231 ESPLPWADCPTRLYKNFT-YDHEPECVASSPTQFYWYRTTLQCSESVDMPENFNYHMAIALIVSW 294
            :.||||:.||  |..|.| ||.  ||..:|.||::|||.||..|.|:.......:..|:.|.::|
  Rat   142 QDPLPWSVCP--LNSNRTGYDE--ECEKASSTQYFWYRKTLNISPSIQENGGVQWEPALCLTLAW 202

  Fly   295 FLVYICMVQGITSSGKIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLDPVVWLE 359
            .:||:|:::|..|:||:||.||:.||.||||:..||:||.||.:|:.::|||:.|.|.:|..|:.
  Rat   203 LMVYLCILRGTESTGKVVYFTALMPYCVLIIYLVRGLTLHGATNGLMYMFTPKIEQLANPKAWIN 267

  Fly   360 AGTQIFFSLGLAFGGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFKATATFDR 424
            |.|||||||||.||.||||:|||..:|:|.:.|::||:.|..||:||.:|.||:.|||||..::.
  Rat   268 AATQIFFSLGLGFGSLIAFASYNEPSNDCQKHAVIVSVINSSTSIFASIVTFSIYGFKATFNYEN 332

  Fly   425 CTE------------ERNGLVAQN---------KTH---------NLPVCDLQTELANSASGTGL 459
            |..            |...|.|.|         .|:         ::..|.|::||..:..||||
  Rat   333 CLNKVILLLTNSFDLEDGFLTASNLEEVKDYLASTYPNKYSEVFPHIRNCSLESELNTAVQGTGL 397

  Fly   460 AFIIFTEAINQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGVVTSLVDMKLFPN-LPKEYIVGALC 523
            |||::.|||.....:|||:||:|.||..||:.|..|....::|.|.|.|:..: ||||.|.|.:|
  Rat   398 AFIVYAEAIKNMEVSQLWSVLYFFMLLMLGMGSMLGNTAAILTPLTDSKVISSYLPKEAISGLVC 462

  Fly   524 FSCCTISMCFANGAGSYIFQLMDSFAGNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNF 588
            ...|.:.|.|...||:|.|.:.:.:|....||:|.|.|.:::.|:||:|||..|:..|||...|:
  Rat   463 LINCAVGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLRAMTGRPLNW 527

  Fly   589 YWMFCWKYLSPCAMVTILLASFY---QLLTEGSSYPAWIGSKGATEGMEWPHWCIVVAFFLILSS 650
            ||...|.::||..::.:.:  ||   .:||....|.||..::|.....::|...:.|...|:.||
  Rat   528 YWKAMWAFVSPLLIIGLFI--FYLSDYILTGTLQYQAWDATQGQLVTKDYPPHALAVIGLLVASS 590

  Fly   651 ILWIPIVAV 659
            .:.||:||:
  Rat   591 TMCIPLVAL 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	249/575 (43%)
Slc6a20	NP_579830.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		2/13 (15%)
Slc6a20	NP_579830.1	SLC5-6-like_sbd	26..601	CDD:294310	250/580 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48419
OrthoDB	1	1.010	-	-		D251682at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930