DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10804 and Slc6a15

DIOPT Version :9

Sequence 1:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001239259.1	Gene:	Slc6a15 / 103098	MGIID:	2143484	Length:	729	Species:	Mus musculus

Alignment Length:	682	Identity:	272/682 - (39%)
Similarity:	402/682 - (58%)	Gaps:	83/682 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 KAELVAIATASADQQDIVEGEKEGEERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAF 156
            |:||:.......| .|..:|.:..:||.:|:||:.::||.:|::||||||||||||.|||||||:
Mouse    36 KSELIVDVQEEKD-TDAEDGSEADDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAY 99

  Fly   157 LVPYFIMLCIQGIPIFYLELAIGQRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAW 221
            |:||.|:|.:.|||:|:|||::|||:|:|:||||:.:||.|||||.:|.||.|.||||||.||.|
Mouse   100 LLPYLILLLVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGW 164

  Fly   222 CLIYLLHSFESPLPWADCPTRLYKNFTYDH-EPECVASSPTQFYWYRTTLQCSESVDMPENFNYH 285
            .|.|...||:.||||..||  |.||.::.: ||||..||.|.:||||..|..:.|:......|:.
Mouse   165 TLFYFSQSFQQPLPWDQCP--LVKNASHTYVEPECEQSSATTYYWYREALDITSSISDSGGLNWK 227

  Fly   286 MAIALIVSWFLVYICMVQGITSSGKIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWET 350
            |.:.|:|:|.:|.:.|::||.|||||:|.:::|||||||.|..|.:.|.|:.||:.|:|||:.|.
Mouse   228 MTVCLLVAWVMVCLAMIKGIQSSGKIMYFSSLFPYVVLICFLIRSLLLNGSIDGIRHMFTPKLEM 292

  Fly   351 LLDPVVWLEAGTQIFFSLGLAFGGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIG 415
            :|:|.||.||.||:||:|||.|||:|||||||..:|||:.||:|||..|..||:.|.:|||:|:|
Mouse   293 MLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLG 357

  Fly   416 FKATATFDRCTEERNGLVAQ---------------------------------NKTH-------N 440
            |||....::|..:.:.::.:                                 .|..       :
Mouse   358 FKANIVNEKCISQNSEMILKLLKMGNISWDVIPHHINLSAVTVEDYRLVYDIIQKVKEEEFAVLH 422

  Fly   441 LPVCDLQTELANSASGTGLAFIIFTEAINQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGVVTSLV 505
            |..|.::.||..:..|||||||.||||:..||.:..|:|:|||||..||:.|.|||:||::|.:|
Mouse   423 LNACQIEDELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMFGTIEGIITPIV 487

  Fly   506 DMKLFPNLPKEYIVGALCFSCCTISMCFANGAGSYIFQLMDSFAGNFPLLIIALFECLSISYIYG 570
            |..   .:.||.:....|.....|.:.|...:|:|...:.|.::...||||:.:.|.:::|::||
Mouse   488 DTF---KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVSFVYG 549

  Fly   571 VRRFSDDIEMMTGSRPNFYWMFCWKYLSPCAMVTILLASFYQLLTEGSSYPAWIGSKGATEGMEW 635
            :.:|.:|:..|.|..|:.|:.:.|||:||..::|:|:||...:......|.|||..|.:.|.:.:
Mouse   550 IDKFIEDLTDMLGFAPSKYYYYMWKYISPLMLLTLLIASIVNMGLSPPGYNAWIKEKASEEFLSY 614

  Fly   636 PHWCIVVAFFLILSSILWIPIVAVLRLCGIKVVEDS----------------DPAWFPEAELREV 684
            |.|.:||.|.|::.:||.:|:|.::|.|.:  ::||                :|......:...:
Mouse   615 PMWGMVVCFSLMVLAILPVPVVFIIRRCNL--IDDSSGNLASVTYKRGRVLKEPVNLEGDDASLI 677

  Fly   685 HGIVPHEPTELERSIFCFNMDGTEGMCCPKYG 716
            ||.:|.|                  |..|.:|
Mouse   678 HGKIPSE------------------MSSPNFG 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	252/581 (43%)
Slc6a15	NP_001239259.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..61		3/19 (16%)
Slc6a15	NP_001239259.1	SLC6sbd_SBAT1	61..640	CDD:212091	253/583 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48419
OrthoDB	1	1.010	-	-		D251682at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101967
Panther	1	1.100	-	-	LDO	PTHR11616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4904
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860