DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10804 and Slc6a8

DIOPT Version :9

Sequence 1:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_598748.1	Gene:	Slc6a8 / 102857	MGIID:	2147834	Length:	640	Species:	Mus musculus

Alignment Length:	575	Identity:	226/575 - (39%)
Similarity:	315/575 - (54%)	Gaps:	83/575 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 RESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIFYLELAIGQRL 182
            ||:|..::.|:::.:|:|||||||||||||..|||||.||:||.::..:.|||||:||:::||.:
Mouse    52 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFM 116

  Fly   183 RKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPLPWA---------- 237
            :.|:|.||: :.|...|:|.:|.|:.:....||..::||...||:.||.:.||||
Mouse   117 KAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPD 180

  Fly   238 --------DCPTRLYKNFTYDHEPECVASSPTQFYWYRTTLQCSESVDMPENFNYHMAIALIVSW 294
                    ||......|.|.|...:  ..||...:|....|:.|..:::|...|:.:.:.|:..|
Mouse   181 CVEIFRHEDCANASLANLTCDQLAD--RRSPVIEFWENKVLRLSTGLEVPGALNWEVTLCLLACW 243

  Fly   295 FLVYICMVQGITSSGKIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLDPVVWLE 359
            .|||.|:.:|:.|:|||||.||.||||||::...||:.|.||.||:.:...|.|..|..|.||::
Mouse   244 VLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWID 308

  Fly   360 AGTQIFFSLGLAFGGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFKATATFDR 424
            ||||||||..:..|.|.|..|||..|||||:|||:::|.|.|||.|||.||||::||.||
Mouse   309 AGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMAT----- 368

  Fly   425 CTEERNGLVAQNKTHNLPVCDLQTELANSASGTGLAFIIFTEAINQFPGAQLWAVLFFLMLFTLG 489
                      :...|...|.:         ||.|||||.:..|:...|.|.|||.|||.||..||
Mouse   369 ----------EQGVHISKVAE---------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLG 414

  Fly   490 IDSQFGTLEGVVTSLVDMKLFPNLPKEY-------IVGALCFSCC---TISMC--FANG-AGSYI 541
            :||||..:||.:|.|:|:     ||..|       |..|||.:.|   .:||.  .:.| .|.|:
Mouse   415 LDSQFVGVEGFITGLLDL-----LPASYYFRFQREISVALCCALCFVIDLSMVTDVSGGKGGMYV 474

  Fly   542 FQLMDSF-AGNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYWMFCWKYLSP--CAMV 603
            |||.|.: |....||..|.:||:.::::||..||.|||..|.|.||..:..:||.:.:|  |..:
Mouse   475 FQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 539

  Fly   604 TILLASFYQLLTEGSS--YPAWIGSKGATEGMEWPHWCIVVAFFLILSSILWIPI 656
            .|....:|:.|...::  ||.|      .|.|.|       ||  .|||:|.:|:
Mouse   540 FIFNIVYYEPLVYNNTYVYPWW------GEAMGW-------AF--ALSSMLCVPL 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	224/573 (39%)
Slc6a8	NP_598748.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
Slc6a8	NP_598748.1	SLC6sbd_CT1	52..626	CDD:271397	226/575 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810