DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10801 and KLHL4

DIOPT Version :10

Sequence 1:NP_570058.1 Gene:CG10801 / 31314 FlyBaseID:FBgn0029660 Length:558 Species:Drosophila melanogaster
Sequence 2:NP_476503.1 Gene:KLHL4 / 56062 HGNCID:6355 Length:720 Species:Homo sapiens


Alignment Length:612 Identity:121/612 - (19%)
Similarity:212/612 - (34%) Gaps:169/612 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 EVKNKLLTPNWYWYRYIDEQIVPLPLSRS------LVQVAEPELSSPISNTSKLCISESSGLIVA 91
            :|| ::|...|.|:.:        |...|      |.|.......:|:....|....:.:||..:
Human    10 DVK-QILRLRWRWFSH--------PFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRNGLKKS 65

  Fly    92 STSSSERITCP---PPPLMLPKTVDADFADILDISRQRRHRRICTSFSINDIPLQIDCPKVDP-- 151
            ::.....|..|   |.|           |....:...::|..| ..|..|:     |.||..|  
Human    66 NSPVHHNILAPVPGPAP-----------AHQRAVQNLQQHNLI-VHFQANE-----DTPKSVPEK 113

  Fly   152 -------ILRAGGTFRDYEII----WKPMSSKLDESCAE-----------NILSRCTRRMNNNEI 194
                   ..||    :|.|::    .:..:::||...:|           ::::...:.:...|.
Human   114 NLFKEACEKRA----QDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMEN 174

  Fly   195 MWKATKMCWFDDL----EIQIESRFFFVSHILFTYFARNFRK--ISSQFLQMPVQKIDMAVLIRI 253
            ..|..::|  |.|    .::|.:....:|.: ..|||..|..  :.::..::.::.:|...|..:
Human   175 YLKEKQLC--DVLLIAGHLRIPAHRLVLSAV-SDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSL 236

  Fly   254 YEW------MLNEEKTFVVGQNLISFYAAAHWLGVHQLIKQAWSTFSADGVYDIWEINAFQAYIM 312
            .::      .|.|:       .:.|..|||..|.:.|:| ...|.|.   :..:...|.......
Human   237 VQYAYTGVLQLKED-------TIESLLAAACLLQLTQVI-DVCSNFL---IKQLHPSNCLGIRSF 290

  Fly   313 AKDYRCPEIMIVMQSRLRKCFLPIVASWEFLEFDVNEVTTLLEQDMLCVNSEDEIFFAVFHWLNY 377
            .....|.|::.|......:.|:.::.:.|||....||::.||..|.:.|..|:.||.|:..|:.:
Human   291 GDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGH 355

  Fly   378 SWTERKKHAVKVMQKVRFGLLSPWLRRSICNMPENDRIGEIGQLPEI-CSLIWEGTLLCQAIIAI 441
            ....|:.....::..:|..||.|.|                  |.:: .|.::.|.|.||.::..
Human   356 DVQNRQGELGMLLSYIRLPLLPPQL------------------LADLETSSMFTGDLECQKLLME 402

  Fly   442 GQ-----PEYRRSRLVRRMLRDFEHKRITERSWVFCEGVPHHHDKKCARYRELTFESFKRFLHRL 501
            ..     || |||     |::....|  ..:|.|   |..:......|.....|.|.:.     |
Human   403 AMKYHLLPE-RRS-----MMQSPRTK--PRKSTV---GALYAVGGMDAMKGTTTIEKYD-----L 451

  Fly   502 HTNSDIFMESLK---------AVPNKI-----------TNTYRCCIDANFCPSYKRTCPMAPF-- 544
            .|||.:.:.::.         .:.||:           .||..|     |.|..|....|.|.  
Human   452 RTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVEC-----FNPVGKIWTVMPPMST 511

  Fly   545 YRTHLDL-------------DNWKYRN 558
            :|..|.:             |.|.|.|
Human   512 HRHGLGVATLEGPMYAVGGHDGWSYLN 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10801NP_570058.1 BACK 306..401 CDD:462237 22/94 (23%)
DUF4734 417..512 CDD:434992 23/100 (23%)
KLHL4NP_476503.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..69 4/22 (18%)
PHA03098 176..698 CDD:222983 87/416 (21%)
Kelch 1 430..476 7/50 (14%)
KELCH repeat 466..509 CDD:276965 9/47 (19%)
Kelch 2 477..523 11/50 (22%)
KELCH repeat 513..557 CDD:276965 6/26 (23%)
Kelch 3 525..570 4/14 (29%)
KELCH repeat 560..603 CDD:276965
Kelch 4 571..617
KELCH repeat 607..658 CDD:276965
Kelch 5 619..670
KELCH repeat 660..699 CDD:276965
Blue background indicates that the domain is not in the aligned region.

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