Protein Alignment CG10801 and Klhl4

DIOPT Version :10

• Sequence 1: NP_570058.1
• Gene: CG10801 / 31314
• FlyBaseID: FBgn0029660
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_766369.2
• Gene: Klhl4 / 237010
• MGIID: 2442829
• Length: 717
• Species: Mus musculus
• Alignment Length: 620
• Identity: 127/620 - (20%)
• Similarity: 215/620 - (34%)
• Gaps: 186/620 - (30%)

  Fly    33 EVKNKLLTPNWYWYRYIDEQIVPLPLSRS-LVQVAEPELSSPISNTSKLCISESSGLIVASTSSS 96
            :|| ::|...|.|:.:..:   ..|.:.| |.|.......:|:....|....:.:||..:::...
Mouse    10 DVK-QILRLRWRWFSHPSQ---GSPNTGSCLQQEGYEHRGTPVQGRLKNHSRDRNGLKKSNSPVH 70

  Fly    97 ERITCP---PPPLMLPKTVDADFADILDISRQRRHRRICTSFSINDIPLQI----DCPKVDP--- 151
            ..|..|   |.|                     .|:|:..::...::.:.:    |.||..|
Mouse    71 HDILTPVPGPAP---------------------THQRVLQNWHQQNVIVHLQANEDTPKAVPEGN 114

  Fly   152 ILRAG--GTFRDYEIIWKPMSSKLDESCAENILSRC-------TRRMNNN--------------E 193
            :|:..  ...||.|::.       |::..:.....|       |...|::              |
Mouse   115 LLKEACEKRSRDLEMMG-------DDNIEDMRAGPCVEEPEQMTTSSNDHYRSRSHADYTLCKME 172

  Fly   194 IMWKATKMCWFDDL----EIQIESRFFFVSHILFTYFARNFRK--ISSQFLQMPVQKIDMAVLIR 252
            ...|..|:|  |.|    .::|.:....:|.: ..|||..|..  :.::..::.::.:|...|..
Mouse   173 SYLKERKLC--DVLLIAGPLKIPAHRLVLSAV-SDYFAAMFTNDVLEARQEEVKIEGVDPNALNS 234

  Fly   253 IYEW------MLNEEKTFVVGQNLISFYAAAHWLGVHQ--------LIKQAWSTFSADGVYDIWE 303
            :.::      .|.|:..    :||:|   ||..|.:.|        ||||...: :..|:....:
Mouse   235 LVQYAYTGVLQLREDTI----ENLLS---AACLLQLTQVIDVCCNFLIKQLHPS-NCLGIRSFGD 291

  Fly   304 INAFQAYIMAKDYRCPEIMIVMQSRLRKCFLPIVASWEFLEFDVNEVTTLLEQDMLCVNSEDEIF 368
            ...           |.|:..|......:.|:.::.:.|||....||::.||..|.:.|..|:.||
Mouse   292 AQG-----------CMELQNVAHKYAMEHFIDVIKNQEFLLLPANEISKLLCSDDINVPDEETIF 345

  Fly   369 FAVFHWLNYSWTERKKHAVKVMQKVRFGLLSPWLRRSICNMPENDRIGEIGQLPEICSLIWEGTL 433
            .|:..|:.:....|::...|::..:|..||||.|...:.|                 |..:.|.|
Mouse   346 HALMQWVGHDAQARQRDLAKLLSYIRLPLLSPQLLADLEN-----------------SSFFSGNL 393

  Fly   434 LCQAIIAIGQ-----PEYRRSRLVRRMLRDFEHKRITERSWVFCEGVPHHHDKKCARYRELTFES 493
            .||.::....     || |||     ||:....|  ..:|.|   |..:......|.....|.|.
Mouse   394 ECQKLLMEAMKYHLLPE-RRS-----MLQSPRTK--PRKSTV---GALYAVGGMDAAKGTTTIEK 447

  Fly   494 FKRFLHRLHTNSDIFMESLK---------AVPNKI-----------TNTYRCCIDANFCPSYKRT 538
            :.     |.|||.|.:.::.         .|.||:           .||..|     |.|..|..
Mouse   448 YD-----LRTNSWIHIGTMSGRRLQFGVAVVDNKLYVVGGRDGLKTLNTVEC-----FNPVTKTW 502

  Fly   539 CPMAPF--YRTHLDL-------------DNWKYRN 558
            ..|.|.  :|..|.:             |.|.|.|
Mouse   503 VVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLN 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10801	NP_570058.1	BACK	306..401	CDD:462237	24/94 (26%)
		DUF4734	417..512	CDD:434992	24/99 (24%)
Klhl4	NP_766369.2	PHA03098	175..697	CDD:222983	95/423 (22%)
		KELCH repeat	465..508	CDD:276965	10/47 (21%)
		KELCH repeat	512..556	CDD:276965	6/26 (23%)
		KELCH repeat	559..602	CDD:276965
		KELCH repeat	606..657	CDD:276965
		KELCH repeat	659..698	CDD:276965