DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myc and MYCN

DIOPT Version :9

Sequence 1:	NP_001259204.1	Gene:	Myc / 31310	FlyBaseID:	FBgn0262656	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001280157.1	Gene:	MYCN / 4613	HGNCID:	7559	Length:	464	Species:	Homo sapiens

Alignment Length:	300	Identity:	65/300 - (21%)
Similarity:	108/300 - (36%)	Gaps:	96/300 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 FNLPYTPASSSPVKSVANSRYPSPSSTPYQNCSSAS----------PSYSP-------------- 497
            |..|......:||.:       :|:|.|....:.||          |..:|
Human   193 FPFPVNKREPAPVPA-------APASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHK 250

  Fly   498 -LSVDSSNVSSSSSS---------------------SSSQSSFTTSSSNKGRKRSSLKDPGLLIS 540
             ||....:..|.|..                     |||.:...|:.:...|.:::...||...|
Human   251 ALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQS 315

  Fly   541 SSSVY---LPGVNNKVTHSSMMSKKSRGKKVVGTSSGNTSPISSGQDV--------DAMDRNWQR 594
            |..:.   || ::.:..:::                  .||....:|.        :|..|..:.
Human   316 SELILKRCLP-IHQQHNYAA------------------PSPYVESEDAPPQKKIKSEASPRPLKS 361

  Fly   595 RSGGIATSTSSNSSVHRKDFVLGFDEADTIEKRNQHNDMERQRRIGLKNLFEALKKQIPTIRDKE 659
            .....|.|.|..:|          |..|: |:|..||.:|||||..|::.|..|:..:|.:...|
Human   362 VIPPKAKSLSPRNS----------DSEDS-ERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNE 415

  Fly   660 RAPKVNILREAAKLCIQLTQEEKELSMQRQLLSLQLKQRQ 699
            :|.||.||::|.:....|..||.:|.::::  .||.:|:|
Human   416 KAAKVVILKKATEYVHSLQAEEHQLLLEKE--KLQARQQQ 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myc	NP_001259204.1	HLH	625..682	CDD:238036	22/56 (39%)
MYCN	NP_001280157.1	Myc_N	10..372	CDD:279405	33/204 (16%)
		Interaction with AURKA. /evidence=ECO:0000269\|PubMed:27837025	19..47
		Interaction with AURKA and FBXW7. /evidence=ECO:0000269\|PubMed:27837025	61..89
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..172
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..294		17/104 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..392		16/86 (19%)
		HLH	379..438	CDD:238036	23/59 (39%)
		Leucine-zipper	433..454		7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11673
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45851
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010