DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myc and MXD1

DIOPT Version :9

Sequence 1:	NP_001259204.1	Gene:	Myc / 31310	FlyBaseID:	FBgn0262656	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_002348.1	Gene:	MXD1 / 4084	HGNCID:	6761	Length:	221	Species:	Homo sapiens

Alignment Length:	145	Identity:	34/145 - (23%)
Similarity:	62/145 - (42%)	Gaps:	39/145 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   586 DAMDRNWQRRSGGIATSTSSNSSVHRKDFVLGFDEADTIEKRNQ-----------HNDMERQRRI 639
            |.::|..:....|.|:....|:.           :.|.:::||:           ||:||:.||.
Human    17 DYLERREREAEHGYASMLPYNNK-----------DRDALKRRNKSKKNNSSSRSTHNEMEKNRRA 70

  Fly   640 GLKNLFEALKKQIPTIRDKERAPKVNILREAAKLCI---------------QLTQEEKELSMQRQ 689
            .|:...|.||..:|...:..|...:::|.: |||.|               ||.:|::.|..|.:
Human    71 HLRLCLEKLKGLVPLGPESSRHTTLSLLTK-AKLHIKKLEDCDRKAVHQIDQLQREQRHLKRQLE 134

  Fly   690 LLSLQLKQRQDTLAS 704
            .|.:: :.|.|::.|
Human   135 KLGIE-RIRMDSIGS 148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myc	NP_001259204.1	HLH	625..682	CDD:238036	22/82 (27%)
MXD1	NP_002348.1	Nuclear localization signal. /evidence=ECO:0000255	21..49		6/38 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..68		9/48 (19%)
		HLH	60..110	CDD:238036	17/50 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..204
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2483
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810