DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myc and Mycn

DIOPT Version :9

Sequence 1:	NP_001259204.1	Gene:	Myc / 31310	FlyBaseID:	FBgn0262656	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001013114.2	Gene:	Mycn / 298894	RGDID:	1584995	Length:	462	Species:	Rattus norvegicus

Alignment Length:	274	Identity:	60/274 - (21%)
Similarity:	103/274 - (37%)	Gaps:	59/274 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   458 NLPYTPASSSPVKSVANSRYPSPSSTPYQNCSSA------SPSYSPLSVDSSNVSSSSS------ 510
            ::|..| :|:|..|...:....|:..|....:.|      |..:..||....:..|.|.
  Rat   205 SVPAAP-TSAPATSAVVTSVSVPAVAPVAAPARAGGRPANSGEHKALSTSGEDTLSDSDDEDDEE 268

  Fly   511 ----------------SSSSQSSFTTSSSNKGRKRSSL----KDPGLLISSSSVYLPGVNNKVTH 555
                            |||:..:.||.:.....|.|:|    ..||.||....|.:...:|....
  Rat   269 EDEEEEIDVVTVEKRRSSSNNKAVTTFTITVRPKTSALGLGRAQPGELILKRCVPIHQQHNYAAP 333

  Fly   556 SSMMSKKSRGKKVVGTSSGNTSPISSGQDVDAMDRNWQRRSGGIATSTSSNSSVHRKDFVLGFDE 620
            |..:..:....:....|..:..|:.|                 :....:.:.|....|
  Rat   334 SPYVESEDAPPQKKIKSEASPRPLKS-----------------VVPPKAKSLSPRNSD------- 374

  Fly   621 ADTIEKRNQHNDMERQRRIGLKNLFEALKKQIPTIRDKERAPKVNILREAAKLCIQLTQEEKELS 685
            ::..|:|..||.:|||||..|::.|..|:..:|.:...|:|.||.||::|.:....|...|.:|.
  Rat   375 SEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHALQANEHQLL 439

  Fly   686 MQRQLLSLQLKQRQ 699
            ::::  .||.:|:|
  Rat   440 LEKE--KLQARQQQ 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myc	NP_001259204.1	HLH	625..682	CDD:238036	21/56 (38%)
Mycn	NP_001013114.2	Myc_N	10..370	CDD:395839	31/182 (17%)
		Interaction with AURKA. /evidence=ECO:0000250\|UniProtKB:P04198	19..47
		Interaction with AURKA and FBXW7. /evidence=ECO:0000250\|UniProtKB:P04198	61..90
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..177
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..290		9/57 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..390		11/81 (14%)
		bHLHzip_N-Myc_like	376..462	CDD:381462	27/78 (35%)
		Leucine-zipper	431..452		7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11367
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45851
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010