DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dnc and PDE5A

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	NP_001074.2	Gene:	PDE5A / 8654	HGNCID:	8784	Length:	875	Species:	Homo sapiens

Alignment Length:	974	Identity:	187/974 - (19%)
Similarity:	349/974 - (35%)	Gaps:	224/974 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 QQQQQQQQQLQQPLLQSQ-------------PHFVPSSGNILSQVTLYSGSNPSTNP-CQSAVQN 292
            :||||.|||.||...|..             .:||..:..  ..|..:......|.| |:..::.
Human    12 RQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATR--EMVNAWFAERVHTIPVCKEGIRG 74

  Fly   293 QGQNSNPNPNQNP---NTNPNQNQQRCSCQPQTSPLPHIKEEEESDQANFKHQTSLKEHQPLPPP 354
            ..::.:....|:|   |:.|....::.|......||..|..::.....:|...:..||..||.||
Human    75 HTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPP 139

  Fly   355 -------------------ITI---ATGYCGS-------------------CESVHHSSATSSSA 378
                               |:.   .|..|..                   ||...:.....|..
Human   140 RFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRL 204

  Fly   379 GTVPPGGQQTQEYIAGTSSTPSPRIKLKFRKPHKSCWSRIVLAPIGSAGGSSSATTVIGSNSNET 443
            ..|..|  .|.|.::...      |:|:        |::.::..:.:.|...:    |.....:.
Human   205 FDVAEG--STLEEVSNNC------IRLE--------WNKGIVGHVAALGEPLN----IKDAYEDP 249

  Fly   444 LASSSTTGGTATTTQNSSSVSVAAHHRLTSSSASALATSHPSNSQLLPTSKMQAEQGS------- 501
            ..::.....|...||:...:.:..|.......|.|:.....:....  |.|.:.:..:
Human   250 RFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTF--TEKDEKDFAAYLAFCGI 312

  Fly   502 -IGDLQKYHSRYLKNRRH----TLANVRFDVENGQGARSPLEGGSPSAGLVLQNLPQRRESF--- 558
             :.:.|.|.:..|:|:|:    .||::.|:.:.             |..::|:.:.....||
Human   313 VLHNAQLYETSLLENKRNQVLLDLASLIFEEQQ-------------SLEVILKKIAATIISFMQV 364

  Fly   559 ----LYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVDRSHGEDLIVTPFAQILASLRSVRNN 619
                ::..|.|.     |.|.:|....|..:.:::|..:.|.|..:.|...:||.      |:|.
Human   365 QKCTIFIVDEDC-----SDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQY------VKNT 418

  Fly   620 LLSLTNVPASNKSRR-PNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQL--ETIQ 681
            :..| |:|..:|.:| |                       :|...|..:.:  .|:..|  ..|:
Human   419 MEPL-NIPDVSKDKRFP-----------------------WTTENTGNVNQ--QCIRSLLCTPIK 457

  Fly   682 THRSVSDMASLKFKRMLNKELSHFSESSRSGNQISE---YICSTFLDKQQEFDLPSLRVEDNP-- 741
            ..:....:...:....:.:........:|:..|..|   ..|...:...|.::.....:....
Human   458 NGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVT 522

  Fly   742 -ELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGT 805
             |:::.:|:|.::...:           :..::....|.:.|...|.
Human   523 LEVLSYHASAAEEETRE-----------LQSLAAAVVPSAQTLKITD------------------ 558

  Fly   806 LLGELDTWGIQIFSIGEFSVNRPLTCV-AYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNP 869
                        ||..:|.::...|.: ...:|....|:.:..:..:....::.:::.:|.|:..
Human   559 ------------FSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVA 611

  Fly   870 FHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMY 934
            :||..||.:..|.....|....::...|.||:...|.||..||:||.|:.|.::..|...||.:|
Human   612 YHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLY 676

  Fly   935 NDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVE 999
             ..|::|:||......:|.:.|..|...:..::.:|..|::...:|:||::.::....:...::.
Human   677 -CHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIR 740

  Fly  1000 TKKVAGSGVLLLDNYTDRIQ---VLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERES 1061
            ..:.         |..|..|   .|..|:...|||..|||.|:.:|...|:..|||.|||:||:.
Human   741 KNQF---------NLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKE 796

  Fly  1062 GMDISP--MCDRHNAT-IEKSQVGFIDYIVHPLWETWADLVH--PDAQDILDTLEENRDYYQSM 1120
             ::|.|  :.:|.... |...||||||.|...|:|.   |.|  .|...:||...:||..:|::
Human   797 -LNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEA---LTHVSEDCFPLLDGCRKNRQKWQAL 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	74/248 (30%)
PDE5A	NP_001074.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		10/16 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..102		4/23 (17%)
		GAF	164..321	CDD:214500	23/178 (13%)
		GAF	347..513	CDD:214500	33/202 (16%)
		PDEase_I	612..847	CDD:278654	74/248 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820