Protein Alignment dnc and PDE5A

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: NP_001074.2
• Gene: PDE5A / 8654
• HGNCID: 8784
• Length: 875
• Species: Homo sapiens
• Alignment Length: 974
• Identity: 187/974 - (19%)
• Similarity: 349/974 - (35%)
• Gaps: 224/974 - (22%)

  Fly   242 QQQQQQQQQLQQPLLQSQ-------------PHFVPSSGNILSQVTLYSGSNPSTNP-CQSAVQN 292
            :||||.|||.||...|..             .:||..:..  ..|..:......|.| |:..::.
Human    12 RQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATR--EMVNAWFAERVHTIPVCKEGIRG 74

  Fly   293 QGQNSNPNPNQNP---NTNPNQNQQRCSCQPQTSPLPHIKEEEESDQANFKHQTSLKEHQPLPPP 354
            ..::.:....|:|   |:.|....::.|......||..|..::.....:|...:..||..||.||
Human    75 HTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPP 139

  Fly   355 -------------------ITI---ATGYCGS-------------------CESVHHSSATSSSA 378
                               |:.   .|..|..                   ||...:.....|..
Human   140 RFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRL 204

  Fly   379 GTVPPGGQQTQEYIAGTSSTPSPRIKLKFRKPHKSCWSRIVLAPIGSAGGSSSATTVIGSNSNET 443
            ..|..|  .|.|.::...      |:|:        |::.::..:.:.|...:    |.....:.
Human   205 FDVAEG--STLEEVSNNC------IRLE--------WNKGIVGHVAALGEPLN----IKDAYEDP 249

  Fly   444 LASSSTTGGTATTTQNSSSVSVAAHHRLTSSSASALATSHPSNSQLLPTSKMQAEQGS------- 501
            ..::.....|...||:...:.:..|.......|.|:.....:....  |.|.:.:..:
Human   250 RFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTF--TEKDEKDFAAYLAFCGI 312

  Fly   502 -IGDLQKYHSRYLKNRRH----TLANVRFDVENGQGARSPLEGGSPSAGLVLQNLPQRRESF--- 558
             :.:.|.|.:..|:|:|:    .||::.|:.:.             |..::|:.:.....||
Human   313 VLHNAQLYETSLLENKRNQVLLDLASLIFEEQQ-------------SLEVILKKIAATIISFMQV 364

  Fly   559 ----LYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVDRSHGEDLIVTPFAQILASLRSVRNN 619
                ::..|.|.     |.|.:|....|..:.:::|..:.|.|..:.|...:||.      |:|.
Human   365 QKCTIFIVDEDC-----SDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQY------VKNT 418

  Fly   620 LLSLTNVPASNKSRR-PNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQL--ETIQ 681
            :..| |:|..:|.:| |                       :|...|..:.:  .|:..|  ..|:
Human   419 MEPL-NIPDVSKDKRFP-----------------------WTTENTGNVNQ--QCIRSLLCTPIK 457

  Fly   682 THRSVSDMASLKFKRMLNKELSHFSESSRSGNQISE---YICSTFLDKQQEFDLPSLRVEDNP-- 741
            ..:....:...:....:.:........:|:..|..|   ..|...:...|.::.....:....
Human   458 NGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVT 522

  Fly   742 -ELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGT 805
             |:::.:|:|.::...:           :..::....|.:.|...|.
Human   523 LEVLSYHASAAEEETRE-----------LQSLAAAVVPSAQTLKITD------------------ 558

  Fly   806 LLGELDTWGIQIFSIGEFSVNRPLTCV-AYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNP 869
                        ||..:|.::...|.: ...:|....|:.:..:..:....::.:::.:|.|:..
Human   559 ------------FSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVA 611

  Fly   870 FHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMY 934
            :||..||.:..|.....|....::...|.||:...|.||..||:||.|:.|.::..|...||.:|
Human   612 YHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLY 676

  Fly   935 NDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVE 999
             ..|::|:||......:|.:.|..|...:..::.:|..|::...:|:||::.::....:...::.
Human   677 -CHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIR 740

  Fly  1000 TKKVAGSGVLLLDNYTDRIQ---VLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERES 1061
            ..:.         |..|..|   .|..|:...|||..|||.|:.:|...|:..|||.|||:||:.
Human   741 KNQF---------NLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKE 796

  Fly  1062 GMDISP--MCDRHNAT-IEKSQVGFIDYIVHPLWETWADLVH--PDAQDILDTLEENRDYYQSM 1120
             ::|.|  :.:|.... |...||||||.|...|:|.   |.|  .|...:||...:||..:|::
Human   797 -LNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEA---LTHVSEDCFPLLDGCRKNRQKWQAL 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	19/127 (15%)
		PDEase_I	870..1110	CDD:459723	74/247 (30%)
PDE5A	NP_001074.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		10/16 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..102		4/23 (17%)
		GAF	164..321	CDD:214500	23/178 (13%)
		GAF	347..513	CDD:214500	33/202 (16%)
		PDEase_I	612..846	CDD:459723	74/247 (30%)