Protein Alignment dnc and PDE8B

DIOPT Version :9

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: NP_001336678.1
• Gene: PDE8B / 8622
• HGNCID: 8794
• Length: 906
• Species: Homo sapiens
• Alignment Length: 996
• Identity: 214/996 - (21%)
• Similarity: 385/996 - (38%)
• Gaps: 258/996 - (25%)

  Fly   278 GSNPSTNPCQSAV---QNQGQNSNPNPNQNPNTNPNQNQQRCSCQPQTSPLPHIKEEEESDQANF 339
            |..||.:..||.|   ::..::|:|....:.:..|            .:|||.:..:.::..|
Human     2 GCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGP------------AAPLPGLFVQTDAADA-- 52

  Fly   340 KHQTSLKEHQPLPPPITIATGYCGSCESVHHSSATSSSAGTVPPGGQQTQEYIAGTSSTPSPRIK 404
                       :||....................:.||||:..|         |.|:|
Human    53 -----------IPPSRASGPPSVARVRRARTELGSGSSAGSAAP---------AATTS------- 90

  Fly   405 LKFRKPH---------KSCWSRIVLAPIGSAGGSSS-ATTVIGSNSNETLASSSTTGGTATTTQN 459
             :.|:.|         ::|::.:   .||::..||: ....:.:..::.::|:....|....||:
Human    91 -RGRRRHCCSSAEAETQTCYTSV---KIGASQTSSNLRVKKVDAYLHQQVSSAEVRIGPMRLTQD 151

  Fly   460 SSSVSVAAHHRLTSSSASALA---TSHPSNSQLLPTSKMQAEQGSIGDLQKYHSRYLKNRRHTLA 521
            ...|.:......:.|.....|   ..:..|....|.|.::.      .|.|:|...:.:.|.|
Human   152 PIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALEC------FLDKHHEIIVIDHRQT-- 208

  Fly   522 NVRFDVENGQGARSPLEGGSPSAGLVLQNLPQRRESFLYRSDSDFEMS---------PKSMSRNS 577
             ..||.|  ...|| :...:||...|:..:..|      .||...|.|         .:....||
Human   209 -QNFDAE--AVCRS-IRATNPSEHTVILAVVSR------VSDDHEEASVLPLLHAGFNRRFMENS 263

  Fly   578 SIAS--------------ERFKEQEASIL---VDRSHGEDLIVTPFAQILASLRSVRNNLL---- 621
            ||.:              .:||.:..:.:   :|..| |.:.:|....::..:......::
Human   264 SIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCH-EAIEITSDDHVIQYVNPAFERMMGYHK 327

  Fly   622 ------SLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQ---- 676
                  .|.::|.|:|:|                              .|.::.::.|:.:
Human   328 GELLGKELADLPKSDKNR------------------------------ADLLDTINTCIKKGKEW 362

  Fly   677 ----------LETIQTHRSVSDMAS--------LKFKRML-----NKELSHFSESSRSGNQISEY 718
                      .::||.|..::.:..        :..|::.     ||::......|...:| :|.
Human   363 QGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQ-TEP 426

  Fly   719 ICSTFLDKQQE-----------FDLPSLRVEDNPELVAANAA--------------AGQQSAG-- 756
            ....:.::::|           .|.|||:....|.:...::.              |.|:::.
Human   427 HSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVT 491

  Fly   757 ---------QYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENE---------- 802
                     :..|:.....|.:    |.|....||:...| .|.|.|:.....||
Human   492 VAEALDRVLEILRTTELYSPQL----GTKDEDPHTSDLVG-GLMTDGLRRLSGNEYVFTKNVHQS 551

  Fly   803 ----------------LGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPK 851
                            :..||...::|...||.:...:..|||..:...:|....:...|.....
Human   552 HSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSET 616

  Fly   852 TFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHP 916
            |...:...:|.:|...|.:|||.|||||..:|...|....::|....|:...||.||.:||||||
Human   617 TLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP 681

  Fly   917 GLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL-LQNQGCDIFCNMQKKQRQTLRKMVIDIVL 980
            |.||.||.|:.||||::|||.:|||:||.|:||:| :::..|:||.|:.:...:|||:.:||:||
Human   682 GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVL 746

  Fly   981 STDMSKHMSLLADLKTMVE---TKKVAGS-------GVLLLDNYTDRIQVLENLVHCADLSNPTK 1035
            :|:|:||...:......:.   ..::.||       |....:|   :|.:...::.|||::||.:
Human   747 ATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVANPCR 808

  Fly  1036 PLPLYKRWVALLMEEFFLQGDKERESGMD-ISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLV 1099
            ||.|...|...:.||:|.|.|:|:..|:. :.|:.||:..:|.|||:.||||.:..:::.|....
Human   809 PLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFA 873

  Fly  1100 HPDAQDILDTLEENRDYYQSM 1120
            |..|  ::..|.:|..:::::
Human   874 HLPA--LMQHLADNYKHWKTL 892

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	94/252 (37%)
PDE8B	NP_001336678.1	PDE8	1..47	CDD:285793	12/56 (21%)
		PAS_9	301..398	CDD:315989	12/126 (10%)
		PDEase_I	635..882	CDD:306695	94/251 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950