DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dnc and Pde7a

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	NP_112342.1	Gene:	Pde7a / 81744	RGDID:	68391	Length:	482	Species:	Rattus norvegicus

Alignment Length:	478	Identity:	133/478 - (27%)
Similarity:	216/478 - (45%)	Gaps:	71/478 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   626 VPASNKSRRP--NQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSD 688
            ||....|||.  :.|||::..|.|....|||...|   ::.|:                    ||
  Rat    16 VPQHVLSRRGAISFSSSSALFGCPHPRQLSQRRGA---ISYDS--------------------SD 57

  Fly   689 MASLKFKRMLN----KELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAA 749
            ..:| :.|||.    :..:.| |:.|.|:.  .||.......|.|.:..          |:|...
  Rat    58 QTAL-YIRMLGDVRVRSRAGF-ETERRGSH--PYIDFRIFHAQSEIEAS----------VSARNI 108

  Fly   750 AGQQSAGQYAR-SRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTW 813
            ....|..:|.| ||..||..:.:...:                   ::.....:...:|.::..|
  Rat   109 RRLLSFQRYLRSSRFFRGATVCRSLNI-------------------LDEDYNGQAKCMLEKVGNW 154

  Fly   814 GIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAAD 878
            ...||.....:....|..:.:.:|....|:....:.......|:..:::.|...||:||::||||
  Rat   155 NFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMVKLRRFLVMIQEDYHSQNPYHNAVHAAD 219

  Fly   879 VTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENH 943
            |||:.:..|..|.|....||.::..:|.||..||:||||:...||:.::..||.:|.:.||||||
  Rat   220 VTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENH 284

  Fly   944 HLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGV 1008
            |...|..||:..|  :|.::..:.|..:...:..::|:||:|:....|:..::.::      .|.
  Rat   285 HWRSAVGLLRESG--LFSHLPLESRHEMEAQIGALILATDISRQNEYLSLFRSHLD------KGD 341

  Fly  1009 LLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHN 1073
            |.||:...|..||:..:.|||:.||.:...|.|:|...:.||||.|||.|::..:.:||:|||..
  Rat   342 LHLDDGRHRHLVLQMALKCADICNPCRNWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRQT 406

  Fly  1074 ATIEKSQVGFIDYIVHPLWETWA 1096
            .:|...|:||:.|:|.||:..||
  Rat   407 ESIANIQIGFMTYLVEPLFTEWA 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	84/227 (37%)
Pde7a	NP_112342.1	PDEase_I	211..431	CDD:395177	84/227 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820