Protein Alignment dnc and Pde2a

DIOPT Version :9

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: NP_001137319.1
• Gene: Pde2a / 81743
• RGDID: 620965
• Length: 935
• Species: Rattus norvegicus
• Alignment Length: 1108
• Identity: 226/1108 - (20%)
• Similarity: 394/1108 - (35%)
• Gaps: 318/1108 - (28%)

  Fly   100 CRGGGSAAPATSPPQTPAQ----TPDELKVIPEDCNLEKSAEQKRDLLERNNKEDDLLNRTVSGS 160
            ||  ....||..|.:...|    .|||..  |:.|              .::.:|.||:   .|:
  Rat    11 CR--SQQYPAARPAEPRGQQVFLKPDEPP--PQPC--------------ADSLQDALLS---LGA 54

  Fly   161 ELDLYGGAGGGTKKHSLA------DTIDTSVTTPISLKTLINDVDEELDQQ-------------- 205
            .:|:.|.....  |.:|:      :|:.|.:....| :.:..|...||.|:
  Rat    55 VIDIAGLRQAA--KDALSAVLPKVETVYTYLVDGES-RLVCEDPPHELPQEGKIREAVISRKRLS 116

  Fly   206 ---LSAADIAAASLASGLVARRAEPETLSDASVSPTAVVQQQQQQQQQLQQPLLQSQPHFVPSSG 267
               |..:|:....||. |||..| |:|                   |.|..|||..:      :|
  Rat   117 CDGLGPSDLLGKPLAR-LVAPLA-PDT-------------------QVLVIPLLDKE------TG 154

  Fly   268 NILSQVTLYSGS-NPSTNPCQSAVQNQG----------QNSNPNPNQNPNTNPNQNQ-------- 313
            .:.:.:.::.|. :.|.......|:...          |...|...||.:.:|:::|
  Rat   155 TVAAVILVHCGQLSDSEEQSLQVVEKHALVALQRVQALQQRRPEAVQNTSADPSEDQKDEKGYTA 219

  Fly   314 ------QRC-------SCQPQTSPLPHIKEE------------EESDQANFK--HQTSLKEHQPL 351
                  |.|       :...|...|.::::|            |::.|.:.|  .:..|.|....
  Rat   220 HDRKILQLCGELYDLDATSLQLKVLRYLQQETQATHCCLLLVSEDNLQLSCKVIGEKVLGEEVSF 284

  Fly   352 PPPITIATGYCGSC----ESVHHSSATSSSAGTVPPGGQQTQEYIAGTSSTPSPRIKLKFRKPHK 412
            |    :..|..|..    :.:.....||...       ||.|..:
  Rat   285 P----LTMGRLGQVVEDKQCIQLKDLTSDDV-------QQLQNML-------------------- 318

  Fly   413 SCWSRIVLAPIGSAGGSSSATTVIGSNSNETLA---SSSTTGGTATTTQNSSSVSVAAHHRLTSS 474
            .|..|.:|           ...||...:::.:|   :.:..||...|.::..::....|:
  Rat   319 GCELRAML-----------CVPVISRATDQVVALACAFNKLGGDFFTDEDERAIQHCFHY----- 367

  Fly   475 SASALATSHPSNSQLLPTSKMQAEQGSIGDLQKYHSRYLKNRRHTLANVRFDVENGQGARSPLEG 539
                      :.:.|..|...|.||            .||.....|..|      .:...:.|:
  Rat   368 ----------TGTVLTSTLAFQKEQ------------KLKCECQALLQV------AKNLFTHLD- 403

  Fly   540 GSPSAGLVLQNLPQRRESFLYRSDSDFEM-SPKSMSRNSSIASERFKEQEASILVDRSHGEDLIV 603
               ...::||.:....     |:.|:.|: |...:.:|..:|    |..:..::.|.|:.   |.
  Rat   404 ---DVSVLLQEIITEA-----RNLSNAEICSVFLLDQNELVA----KVFDGGVVDDESYE---IR 453

  Fly   604 TPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIE 668
            .|..|.:|...:....:|::.:..|.....|....|:..|:.|....|:....:....:| :.:.
  Rat   454 IPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVA-ELVN 517

  Fly   669 ELD--WCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFLDKQQEFD 731
            :::  |.....|.:.|..|:....|:... :|.|:::.....|...|::..|
  Rat   518 KINGPWFSKFDEDLATAFSIYCGISIAHS-LLYKKVNEAQYRSHLANEMMMY------------- 568

  Fly   732 LPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVE 796
              .::|.|:                :|.:.......|::.|.      |:..:||         .
  Rat   569 --HMKVSDD----------------EYTKLLHDGIQPVAAID------SNFANFT---------Y 600

  Fly   797 TPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLE 861
            |||.      |.|.||                 :....::.|....:.:..|...|...|...::
  Rat   601 TPRS------LPEDDT-----------------SMAILSMLQDMNFINNYKIDCPTLARFCLMVK 642

  Fly   862 DHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACI-HDVDHPGLTNQFLVN 925
            ..| :|.|:||.:||..|:....:|.....|......:|: .|||.:|: ||:||.|..|.|.|.
  Rat   643 KGY-RDPPYHNWMHAFSVSHFCYLLYKNLELSNYLEDIEI-FALFISCMCHDLDHRGTNNSFQVA 705

  Fly   926 SSSELALMYNDE-SVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMS 989
            |.|.||.:|:.| ||:|.||.|.|..:|...||:||.:..:|..|.:..::.||:|:||::.|:.
  Rat   706 SKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLR 770

  Fly   990 LLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHC-----ADLSNPTKPLPLYKRWVALLME 1049
            :..||:.|.|.            .|....:....|:.|     .|||:.||.....::...|:.:
  Rat   771 IFKDLQKMAEV------------GYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYK 823

  Fly  1050 EFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENR 1114
            |||.|||.|:..|.....|.||..|.|.:.|:.|:::|..|:::...|| .|.|.::.:.:..||
  Rat   824 EFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDL-FPKAAELYERVASNR 887

  Fly  1115 DYY 1117
            :::
  Rat   888 EHW 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	80/247 (32%)
Pde2a	NP_001137319.1	GAF	235..382	CDD:214500	29/203 (14%)
		GAF	404..553	CDD:214500	30/162 (19%)
		PDEase_I	650..883	CDD:278654	80/246 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820