DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dnc and pde9aa

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	XP_009302928.1	Gene:	pde9aa / 799942	ZFINID:	ZDB-GENE-130920-1	Length:	509	Species:	Danio rerio

Alignment Length:	529	Identity:	141/529 - (26%)
Similarity:	241/529 - (45%)	Gaps:	114/529 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   617 RNNLLSLTNVPASNKSRRPNQSSSASRSGNP------PGAPLSQGEEAYTRLATDTIEELD--WC 673
            ||..:||.:...:..|..|...::..||  |      .|:.|:..||.:..:.|...|:..  :.
Zfish    45 RNTSISLLDSTGAMVSIDPTMPNNTERS--PYKVVPVTGSQLADKEELFQNVLTQVAEQFSRAFK 107

  Fly   674 LDQLETIQTHRSVSDMASLKFKRM------------LNKELSHFSESSRSGNQISEYICSTFLDK 726
            :::|:|..|:|    :|.|: ||:            ...::....|...|.|.      |:||
Zfish   108 INELKTEVTNR----LAMLE-KRVELEGMKVVEIEKCRSDIKKLREEMASRNN------SSFL-- 159

  Fly   727 QQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERL- 790
                       |||.:|                   :||....|.      |..|.:..|.|.|
Zfish   160 -----------EDNKKL-------------------TPRRDVPSY------PKYHLSQDTVEALK 188

  Fly   791 -PTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFL 854
             |.|                 |.|        ::..|..|:|:.: ::....|:....|.|.|..
Zfish   189 QPLF-----------------DVW--------QWESNEMLSCLEH-MYHDLGLVKDFNINPITLK 227

  Fly   855 NFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLT 919
            .::..:.|:| ::|||||..|...|||....::....|:..||.:::...:.||..||:||||..
Zfish   228 RWLLCIHDNY-RNNPFHNFRHCFCVTQMMYSMIYLCGLQEKFTQVDILILMTAAVCHDLDHPGYN 291

  Fly   920 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDM 984
            |.:.:|:.:|||:.|||.|.|||||.||||::.....|:||.:...:..:.:|:..|.::|:|||
Zfish   292 NTYQINARTELAVRYNDISPLENHHCAVAFQIFSQPDCNIFASFDPEAFKQIRQGTITLILATDM 356

  Fly   985 SKHMSLLADLKTMVETKKVAGSGVLLLD-NYTDRIQVLEN-LVHCADLSNPTKPLPLYKRWVALL 1047
            ::|..::...|..|::          .| |..:.:..|:. |:.|.|:||..:|:.:.:.||..|
Zfish   357 ARHGEIMDSFKQKVDS----------FDYNNEEHVTCLKMVLIKCCDISNEVRPMEVAEPWVDCL 411

  Fly  1048 MEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDIL-DTLE 1111
            :||:|:|.|:|:..|:.::|..||...|...:|:|||.:::.|::||...| .|..:::: ..|.
Zfish   412 LEEYFMQSDREKAEGLPVAPFMDREKVTKPTAQIGFIKFVLIPMFETVMKL-FPQIEEVMVQPLR 475

  Fly  1112 ENRDYYQSM 1120
            |:||.|:.:
Zfish   476 ESRDKYEEL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	80/243 (33%)
pde9aa	XP_009302928.1	PDEase_I	242..472	CDD:278654	80/240 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850