DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dnc and pde5a

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	XP_012821480.2	Gene:	pde5a / 780273	XenbaseID:	XB-GENE-479676	Length:	943	Species:	Xenopus tropicalis

Alignment Length:	904	Identity:	179/904 - (19%)
Similarity:	327/904 - (36%)	Gaps:	196/904 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 AVQNQGQN---SNPNPNQNPNTNPNQNQQRCSCQPQTSPLPHIKEEEESDQANFKHQTSLKEHQP 350
            |.:.||:|   |||....:.||......::.|......||..|..::......|...:..||..|
Frog   137 ASKEQGKNNSESNPQVCYSENTTQGTPVRKISASEFDRPLRPIVVKDSVGTLKFLSDSEKKELMP 201

  Fly   351 L-PPPITIATGYCGS-----------------CES----VHHSSATSSSAGTVPPGGQQTQEYIA 393
            | ||.::.|...|..                 |..    :|...|....:..:.......::::.
Frog   202 LQPPSLSRAGDQCSRLLELVKDISSHLDVTTLCHKIFLHIHELIAADRYSLFLVCEDSSNKKFLV 266

  Fly   394 --------GTSSTPSPR--IKLKFRKPHKSCWSRIVLAPIGSAGGSSSATTVIGSNSNETLASSS 448
                    ||:...:..  |:|:        |::.::..:...|...:    |.....::..::.
Frog   267 SRLFDVAEGTTVEQASNNCIRLE--------WNKGIVGHVAEFGQPLN----IKDAYQDSRFNAE 319

  Fly   449 TTGGTATTTQNSSSVSVAAHHRLTSSSASALATSHPSNSQLLPTSKMQAEQG----------SIG 503
            ....|...||:...:.:..|.......|.|:.....||.    |...|.|:.          .:.
Frog   320 VDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGSNG----TFTDQDEKDFAAYLAFCGIVLH 380

  Fly   504 DLQKYHSRYLKNRRH----TLANVRFDVENGQGARSPLEGGSPSAGLVLQNLPQRRESFLYRSDS 564
            :.|.|.:..|:|||:    .||.:.|:.:..      ||.........:.:..|.:...::..|.
Frog   381 NAQLYETSLLENRRNQVLLDLATLIFEEQQS------LEVILKKIAATILSFMQAQRCTIFIVDE 439

  Fly   565 DFEMSPKSMSRNSSIASERFKEQEASILVDRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVPAS 629
            |   ||.:.|....:.|:..  :|::..|.|.:....:...:||.:|       |.:...|:|..
Frog   440 D---SPDTFSSVFHMESDEL--EESADAVKREYDVSKMNYMYAQYVA-------NTMEAINIPDI 492

  Fly   630 NKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKF 694
            .|..|               .|.:.|.|.                      :..:.:..:.....
Frog   493 CKDTR---------------FPWTNGNEE----------------------KNFKHIQSLLCSPI 520

  Fly   695 K-----------RMLNK------ELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNP- 741
            |           :::||      ::..|:::.....:.....|...:...|.|::....:....
Frog   521 KNAKKNKVIGVCQLVNKVDENSGKIKAFNKNDEQFLEAFAIFCGLGIQNTQMFEVVERAMAKQMV 585

  Fly   742 --ELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELG 804
              |:::.:|:|.::.                               |.|...|.|...|....|
Frog   586 TLEILSYHASAAEEE-------------------------------TMELQVTAGAIVPSAQSL- 618

  Fly   805 TLLGELDTWGIQIFSIGEFSVNRPLTCVAYT-IFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDN 868
                     .:..|...:|.::...|.:|.: :|....|:.:..:..:|...::.:::.:|.|:.
Frog   619 ---------KLTEFYFSDFELSDMETTLATSRMFTDLNLVQTFQMKYETLCRWILSVKKNYRKNV 674

  Fly   869 PFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALM 933
            .:||..||.:..|.....|.|..::|....||:...:.|...||:||.|:.|.|:..|...||.:
Frog   675 AYHNWRHAFNTAQCMFAALRTGKIQGKLNDLEILALMIATLSHDLDHRGVNNSFIQRSEHPLAQL 739

  Fly   934 YNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMV 998
            | ..|::||||......:|.:||..|...:..:..:|:.||:...:|:||::.::...:|...:|
Frog   740 Y-CHSIMENHHFDQCLMILNSQGNQILSGLSVQDYKTVLKMIKQAILATDLALYIKRRSDFFELV 803

  Fly   999 ETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGM 1063
            ..||      ...|:.:.:...|..|:...|||..|||.|:.:|...|:..||:.||||||.. :
Frog   804 NKKK------FKWDDPSQKELFLAMLMTACDLSAITKPWPVQQRIAELVASEFYDQGDKERRE-L 861

  Fly  1064 DISPMCDRHNA----TIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQ 1118
            :|.|: |..|.    .|...||||||.:...|:|.... :......:||..:.||..:|
Frog   862 NIEPI-DLMNREKKDKIPSMQVGFIDAVCLELYEALTQ-ISESCYPLLDGCQRNRQMWQ 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	76/244 (31%)
pde5a	XP_012821480.2	GAF	229..386	CDD:214500	22/172 (13%)
		GAF	412..577	CDD:214500	30/213 (14%)
		PDEase_I	676..911	CDD:395177	76/244 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920