Protein Alignment dnc and pde2a

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_031751996.1
• Gene: pde2a / 780063
• XenbaseID: XB-GENE-5945995
• Length: 964
• Species: Xenopus tropicalis
• Alignment Length: 824
• Identity: 183/824 - (22%)
• Similarity: 305/824 - (37%)
• Gaps: 229/824 - (27%)

  Fly   471 LTSSSASALATSHPSNSQLLPTSKMQAEQGSIGDLQKYHSRYLKN---------RRHTLANVRFD 526
            |.....|:||...|.:.|:|....:..:...:..:...|...|.:         .:|||...:..
 Frog   136 LLGQQMSSLAAPLPPDKQVLILPLLDQDTARVVSVILLHCSQLSDSDEQNLRTLEKHTLVACKRV 200

  Fly   527 VENGQGARSPLEGGSPSAGLVLQN-----LPQRRESF-------------LYRSDSD-------- 565
            :...:...||....||.:....||     .|...||:             ||..|:.
 Frog   201 LAIQKLQPSPQVPPSPLSPRTYQNSLPKPSPTANESYDELDRKILQLCGELYDLDAASLQIKVIH 265

  Fly   566 -FEMSPKS-------MSRNS-----SIASERFKEQEASILVDRSHGEDLIVTPFAQILASLRSVR 617
             .|...:|       :|.:|     .:...:..|:|.|..:...|        ..|::...:|:.
 Frog   266 YLEQQTQSPCCCLLLVSEDSHQLFCQVVGGKVLEEEISFPLTFGH--------LGQVVDKKKSIT 322

  Fly   618 ------------NNLL-----SLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATD 665
                        ||:|     |:..||..  ||..:|..:.:.:.|..|...::.:|
 Frog   323 LQDISSEEHRQLNNMLGFEVHSMLCVPVI--SRATSQVVALACAFNKQGGKYTEVDE-------- 377

  Fly   666 TIEELDWCLDQLETIQTHRSVSDMASLKFKRM---------LNKEL-SHFSESS--------RSG 712
              .::..|.....|:.|    |.:|..|.:::         :.|.| :|..:.|        .:.
 Frog   378 --HKIQHCFCYTSTVLT----STLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEAR 436

  Fly   713 NQISEYICSTFLDKQQEFDLPSLRVED----NPELVAANAAAGQQSAGQYARSRSPRGPPMSQIS 773
            |..:..|||.||.::|..:|.: :|.|    :.|.......|.|..||..|.:        .||.
 Frog   437 NLSNAEICSVFLLERQSHELVA-KVFDGGVVDDESYEIRIPADQGIAGHVATT--------GQIL 492

  Fly   774 GVKRPLSHTNSFTGERLPTFGVET------PRENELGTLLG------------------ELDT-- 812
            .:|...||...:.|....| |..|      |.:||...::|                  :|.|
 Frog   493 NIKDAYSHPLFYRGVDDST-GFRTRNILCFPIKNESNEVIGVAELVNKINGPGFTKFDEDLATAF 556

  Fly   813 ---WGIQIF-------------------------------------SIGEFSV------------ 825
               .||.|.                                     |.|..||
 Frog   557 SIYCGISIAHSLLYKQVREAQFRSHLANEMMMYHMKVCEDETKKLQSNGIVSVCQIDPGFASFSY 621

  Fly   826 -------NRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQST 883
                   :..:.|| .::|:....:.:..|...|.:.|...::..| :|.|:||.:||..|:...
 Frog   622 TPRSLPEDDTVMCV-ISMFEDMGFVNNYKIDRTTLIRFCLMVKKGY-RDPPYHNWMHAFSVSHFC 684

  Fly   884 NVLLNTPALEGVFTPLEVGGALFAACI-HDVDHPGLTNQFLVNSSSELALMYNDE-SVLENHHLA 946
            .:|.....|......:|: .|||.:|: ||:||.|..|.|.|.|.|.||.:|:.| ||:|.||.|
 Frog   685 YLLFKNLELVNYLEYIEI-FALFVSCLCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFA 748

  Fly   947 VAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLL 1011
            .|..:|.:|||:|.....:|..|.:..::.||:|:||::.|:.:..:|..|.:
 Frog   749 QAIAILNSQGCNILEQFSRKDYQRMLDLMRDIILATDLAHHLRIFKELTRMSQ------------ 801

  Fly  1012 DNYTDRIQVLENLVHC-----ADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDR 1071
            |.:..:.:....|:.|     :|||:.||.....::...|:.:|||.|||.|:..|...|.|.||
 Frog   802 DGFDPQNKHHHYLLICLLMTSSDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPSEMMDR 866

  Fly  1072 HNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRD 1115
            ..|.|.:.|:.|:::|..|::....|| .|.:.::.:.:..||:
 Frog   867 EKAYIPELQISFMEHIAMPIYNLLKDL-FPRSAELYERVATNRE 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	29/156 (19%)
		PDEase_I	870..1110	CDD:459723	78/246 (32%)
pde2a	XP_031751996.1	GAF	255..401	CDD:214500	29/169 (17%)
		GAF	423..574	CDD:214500	35/160 (22%)
		PDEase_I	671..904	CDD:459723	78/246 (32%)