Protein Alignment dnc and pde4cb

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_068080368.2
• Gene: pde4cb / 571344
• ZFINID: ZDB-GENE-030131-4075
• Length: 723
• Species: Danio rerio
• Alignment Length: 725
• Identity: 409/725 - (56%)
• Similarity: 498/725 - (68%)
• Gaps: 69/725 - (9%)

  Fly   471 LTSSSASALATSHPSNSQLLP--TSKMQAEQG-SIGDLQKYHSRYLKNRRHTLANVRFDVENGQG 532
            |.|.::||:.... |...|||  ..:..|..| .:.||:..:...|. |..|.....||||||..
Zfish    17 LQSKTSSAIRRRF-SGPLLLPPLARRHSALDGKKLKDLEALYKSALA-RADTQKETDFDVENGLS 79

  Fly   533 -ARSPLEGGSPSAGLVLQNLPQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVDRS 596
             .||.|: .|||:|||||...||||||||||||||::|||:||||||.|||             .
Zfish    80 MGRSSLD-PSPSSGLVLQANSQRRESFLYRSDSDFDLSPKTMSRNSSTASE-------------L 130

  Fly   597 HGEDLIVTPFAQILASLRSVRNNLLSLTNV-PASNKSRRPNQSSSASRSGNPPGA-PLSQGEEAY 659
            ||||:|||||||:|||||:||.|:.:||:: ..|||  ||:.:       ||..| ..:..:|||
Zfish   131 HGEDMIVTPFAQVLASLRTVRGNVAALTHMQDRSNK--RPSGT-------NPQSACKTNLSDEAY 186

  Fly   660 TRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFL 724
            .:|..:|:||||||||||||:||..|||:|||.|||||||:||:..||:||||||:||:|.||.|
Zfish   187 QKLTVETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTQLSETSRSGNQVSEFIASTIL 251

  Fly   725 DKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGER 789
            .||.:.:|.|             ||..::.          :..|||||||| |.||.:.|.....
Zfish   252 QKQYDVELLS-------------AACKEEK----------KRRPMSQISGV-RKLSPSPSLPPTC 292

  Fly   790 LPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFL 854
            :|.|||.|..|:.|...|.:||.|||.||.|.|:|.|||||.:.|||||.|:||.:..||..|||
Zfish   293 IPRFGVNTQHESLLAKELEDLDRWGIDIFKIAEYSGNRPLTVMMYTIFQERDLLKTFKIPSDTFL 357

  Fly   855 NFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLT 919
            .|:.||||||..|..:||::|||||.|||:|||:|||||.|||.||:..||||:.||||||||:|
Zfish   358 TFLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEDVFTDLEIMAALFASAIHDVDHPGVT 422

  Fly   920 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDM 984
            ||||:|::|||||||||.||||||||||.|||||.:.||||||:.|||||:||:|.||:||:|||
Zfish   423 NQFLINTNSELALMYNDASVLENHHLAVGFKLLQEENCDIFCNLSKKQRQSLRQMTIDMVLATDM 487

  Fly   985 SKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLME 1049
            ||||:.|||||||||||||...||||||||:||||||:|:|||||||||||||.||::|...:|.
Zfish   488 SKHMNFLADLKTMVETKKVTSQGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLELYRKWTDRIMV 552

  Fly  1050 EFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENR 1114
            |||.|||:||:.|:|:|||||:|.|::|.:||||||||:|||||||||||||||||||||||:||
Zfish   553 EFFSQGDRERDKGIDVSPMCDKHTASMENTQVGFIDYIIHPLWETWADLVHPDAQDILDTLEDNR 617

  Fly  1115 DYYQSMIP--PSPPPSGVDENP------QEDRIRFQVTLEESDQENLAELEEGDESGGESTT--- 1168
            ::||||||  |||.|...|..|      ..::.:|::||||.|.|...|.|..|.....:.|
Zfish   618 EWYQSMIPRSPSPTPEEHDSRPTGVTGSAGEKFQFELTLEEEDGELETEEEHTDIERSRTMTDPE 682

  Fly  1169 ---TGTTGTT 1175
               |...|.|
Zfish   683 HPQTSPLGIT 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	71/123 (58%)
		PDEase_I	870..1110	CDD:459723	181/239 (76%)
pde4cb	XP_068080368.2	None