Protein Alignment dnc and pde11al

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_697567.3
• Gene: pde11al / 569112
• ZFINID: ZDB-GENE-031118-106
• Length: 918
• Species: Danio rerio
• Alignment Length: 782
• Identity: 167/782 - (21%)
• Similarity: 284/782 - (36%)
• Gaps: 205/782 - (26%)

  Fly   515 NRRHTLANVRFDVENGQGAR---SPLEG-------GSPSAGLVLQ-----NLPQRRESFLYRSDS 564
            :.:.||.:..|||.:|...|   |.|:.       |....|.|.:     |.|...|...:..:.
Zfish   202 SHKRTLVSKFFDVHSGTTVRPSSSTLDSNEVQVPWGKGIIGYVAEHGETVNTPNAYEDHRFSDEI 266

  Fly   565 DFEMSPKSMS------RNS-------------SIASERFKEQEASILVDRSHGEDLIVTPFAQIL 610
            |.....|:.|      |||             :.:...|.|.:..:|        .:..||..|
Zfish   267 DKLTGYKTQSILCMAIRNSDGEVIGVVQAINKNPSGTPFTEDDEKVL--------QMYLPFCGI- 322

  Fly   611 ASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEE---LDW 672
                       |::|....::||:..:.|                 .|...:..|..||   |:.
Zfish   323 -----------SISNAKLFSESRKEYERS-----------------RALLEVVNDLFEEQTDLEK 359

  Fly   673 CLDQ-----LETIQTHRS----VSDMAS--LKFKR---------MLNKELSHFSESSRS---GNQ 714
            .:.:     |..:|..|.    :.|:.|  :||.:         .:::::|....|...   .|.
Zfish   360 IVRKIMQRALTLLQCERCSVLLLEDIHSPVVKFSQTFELMSPLCSVDRDISMEKVSCSDWLINNS 424

  Fly   715 ISEYICSTFLD-------KQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARS--RSPRGPPMS 770
            |:|.:.||.|.       :...||                 |...|::|.:.||  ..|......
Zfish   425 IAELVASTGLPVNISDVCQDPRFD-----------------AEADQASGFHIRSVLCVPIWNRTH 472

  Fly   771 QISGVKRPLSHTNS----------------FTG-------------------------------- 787
            ||.||.:.|:..:.                |.|
Zfish   473 QIIGVAQILNRLDRKTFNDADQRLFEAFVIFCGLGINNTMMYNQVKKTWAKQSVALDMLSYHATC 537

  Fly   788 -----ERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSV-NRPLTCVAYTIFQSRELLTSL 846
                 :||.  ..:.|..:||          ||..|...:||: |..:...:..:|....::...
Zfish   538 SKAEVDRLK--AAKIPLSSEL----------GIDEFHFNDFSLDNDAMITASLRMFLELGVVQKF 590

  Fly   847 MIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIH 911
            .|..:....::.|:..:| :...:||..||.:|:|...:::.|.|.:.|.|..|....:.....|
Zfish   591 KIDYEVLCRWLLTVRKNY-RTVAYHNWRHAFNVSQCMFIMITTAAFQEVLTETETLALMVGCFCH 654

  Fly   912 DVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVI 976
            |:||.|..|.|...|.|.|||:|...:.||:||...|..:||::|.:||.|:..|:...:.:::.
Zfish   655 DLDHRGTNNAFQAKSGSALALLYGTSATLEHHHFNHAVMILQSEGHNIFANLCSKEYCNMMQLLK 719

  Fly   977 DIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYK 1041
            ..:||||::.:..........|.:.:.:.|.    :.:.|..:.:  |:...||...|:|..:.|
Zfish   720 QAILSTDLTLYFKKRTTFFDCVLSGQFSWSD----EEHRDMFRSM--LMTACDLGAVTRPWEISK 778

  Fly  1042 RWVALLMEEFFLQGDKERESGMDISP--MCDRHNA-TIEKSQVGFIDYIVHPLWETWADLVHPDA 1103
            :...|:..|||.|||:|| |.:.::|  :.||:.. .:...|:.:||.|..||:|....| :...
Zfish   779 QVAELVTSEFFEQGDRER-SELKLTPAAIFDRNRKDELPVLQLEWIDGICKPLYEALVKL-NRKL 841

  Fly  1104 QDILDTLEENRDYYQSMIPPSPPPSGVDENPQEDRIRFQVTLE-ESDQENLAELEEGDESGGEST 1167
            |.::|.::.||..::.:...........|.   :.:....|.| ||.|.......||...|.|..
Zfish   842 QPMVDGIDANRKKWEELCLSYQQTRRASEC---NTVETDSTHEPESSQSEATNQNEGSTHGVEPK 903

  Fly  1168 TT 1169
            .|
Zfish   904 QT 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	27/147 (18%)
		PDEase_I	870..1110	CDD:459723	72/242 (30%)
pde11al	XP_697567.3	GAF	108..>386	CDD:441805	41/220 (19%)
		GAF	<332..>524	CDD:441805	38/225 (17%)
		PDEase_I	613..848	CDD:459723	72/242 (30%)